Structural changes of peripheral bodies of the immune system at different types of antigenic action in an experiment

Abstract

We studied the microanatomical organization of larynx lymphoid tissue and mesenteric lymph nodes of rats based on antigenic exposure. Changes in the larynx lymphoid tissues were analyzed after diamond dust exposure to a body in different periods of the experiment. Mesenteric lymph nodes were examined after experimental exotoxicosis through the intraperitoneal injection of 50% oil solution of carbon tetrachloride. We determined that the 3-day exposure to a larynx mucous membrane with diamond dust caused increase of the number of lymphoid tissue. The prolonged exposure (30 days) resulted in reduction of the amount of lymphoid tissue on larynx walls. In MLN as a reaction to exotoxicosis the hypertrophy of paracortex, cortex, lymphoid nodules, and growth of pulpous strands, marginal, cortical and medullar sinuses in lymph nodes were observed. In both cases the changes occurred due to the activation of a lymphoid apparatus focused on processing the toxicant.