Morphological changes in gastric mucosa in hemorrhagic fever with renal syndrome
Abstract
Gastric biopsy specimens in acute hemorrhagic fever with renal syndrome cases were examined using indirect immunolabeling of the viral antigen assisted by confocal laser scanning and electron microscopy. Degenerative and necrotic cellular changes combined with signs of focal hyperplasia of gastric focal epithelium and incipient shift of epithelial differentiation towards mucocytes to the profound epithelial proliferation combined with poor differentiation of highly specialized cells (chief and parietal cells) were revealed. Ultrastructural virus-specific inclusions in the cells were found and dependence thereof on the adaptive rearrangement of gastric mucosa was established.
About the Authors
A. N. Evseyev
Far Eastern state Medical University of Ministry of healthcare of the Russian Federation
Russian Federation
Russian Federation
Alexey N. Evseev - candidate of medical Sciences, head of the course of pathological anatomy Department of pathological anatomy and forensic medicine, «Far Eastern state Medical University» of Ministry of healthcare of the Russian Federation.
Khabarovsk str. Muravyov-Amursky 35
Contact phone 89141580564 slave. 8(4212)409564
N. G. Plekhova
Pacific medical University of Ministry of healthcare of the Russian Federation
Russian Federation
Russian Federation
Natalya G. Plekhova - Head of Central research laboratory of «Pacific medical University» of Ministry of healthcare of the Russian Federation.
690002, Vladivostok, Prospekt Ostryakova, 2
A. A. Evseyeva
Far Eastern state Medical University of Ministry of healthcare of the Russian Federation
Russian Federation
Russian Federation
Alena A. Evseeva - senior laboratory of the Department of pathological anatomy and forensic medicine of the medical faculty «Far Eastern state Medical University» of Ministry of healthcare of the Russian Federation.
Khabarovsk str. Muravyov-Amursky 35
References
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Review
For citations:
Evseyev A.N., Plekhova N.G., Evseyeva A.A. Morphological changes in gastric mucosa in hemorrhagic fever with renal syndrome. Yakut Medical Journal. 2015;(2):67-69.
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