Features of Metabologram at Patients with Coronary Heart Disease and Obesity
Abstract
Features of metabologram in patients with coronary heart disease and obesity according to indirect calorimetry were studied. It wasrevealed that the respiratory quotient (RQ) was significantly higher in patients with angina and obesity. Elevated levels of RQ can be seen as a predictor of cardiovascular risk and reflect a violation of fat oxidation.
About the Authors
N. B. PavlyukRussian Federation
Pavliuk Natalia Borisovna internal postgraduate student
H. H. Sharafetdinov
Russian Federation
Sharafetdinov HajderHamzjarovich– doct. med. sciences, Prof., head of the Department FSBSE «Food Research Institute»
E. S. Chedia
Russian Federation
Chediya Elena Semenovna–cand. med. sciences, senior lecturer, therapist FSBSE “Food Research Institute”
References
1. PogozhevaA.V.Dietoterapiyaserdechnososudistykhzabolevaniy[ Diet therapy forcardiovascular diseases] / A.V. Pogozheva, S. A. Derbeneva // Russian medical journal.  2009.  № 5. – Р. 5153.
2. Pogozheva A. V.Sovremennyeprinsipylechebnogopitaniyapriishemicheskoybolezniserdtsa[ Modern principles of clinical nutrition in coronary heart disease] / A. V. Pogozheva // ConsiliumMedicum. – 2009. – Vol. 11, № 10. – P. 8493.
3. Pokazatelimetabolizma I marker serdechnososudistogoriska u bol’nykh s razlichnoystepenjuozhireniya [Indices of metabolism and markers of cardiovascular risk in patients with different degrees of obesity / A. R. Bogdanov, S. A. Derbeneva [et al.] // Doctor.ru. – 2013. – Vol. 80, № 2. – Р. 3138.
4. Pokazatelipischevogostatusakakpotetsial’nye factory riskarazvitiyaserdechnososudistykhzabolevaniy (porezul’tatamissledovaniyasredizhiteleyMoskvy) [Indicators of nutritional status as potential risk factors for cardiovascular disease (based on results of the study among residents of Moscow) / A. A. Golubeva, Y. Lin, A. R. Bogdanov [et al.] // Voprosydieto;ogii [Issues of Nutrition]. – 2013. – Vol. 3, № 3. – P. 511.
5. CarstensM.T. Fasting substrate oxidation in relation to habitual dietary fat intake and insulin resistance in non diabetic women: a case for metabolic flexibility? / M.T. Carstens, J.H. Goedecke // NutrMetab (Lond). – 2013. – Vol. 10, № 8.
6. Elia M. Organ and tissue contribution to metabolic rate / M. Elia, J. Kinney, H. Tucker // Energy Metabolism, Tissue Determinants and Cellular Corollaries.  Raven Press; New York, NY, USA.  1992. – P. 61–80.
7. Family history of diabetes links impaired substrate switching and reduced mitochondrial content in skeletal muscle / B. Ukropcova, O. Sereda // Diabetes. – 2007. – Vol. 56, № 3. – P. 720–727.
8. Ferro Y. Fat utilization and arterial hypertension in overweight/obese subjects / Y. Ferro, C. Gazzaruso // J. Transl. Med. – 2013. –Vol. 11. – P. 159.
9. Galgani J.E. Metabolic flexibility and insulin resistance / J.E. Galgani, M. Cedric, E. Ravussin// Am J PhysiolEndocrinolMetab. – 2008. – Vol. 295, № 5. – P. 1009–1017.
10. Low ratio of fat to carbohydrate oxidation as predictor of weight gain: Study of 24h RQ / F. Zurlo, S. Lillioja [et al] // Am. J. Physiol. – 1990. –Vol. 259. – P. 650–657.
11. Metabolic fuel utilisation and subclinical atherosclerosis in overweight/obese subjects / T. Montalcini, C. Gazzaruso [et al.] // Endocrine. –2013. – Vol.44. – P. 380–385.
12. Nutrients Utilization in Obese Individuals with and without Hypertriglyceridemia / T. Montalcini, T. Lamprinoudi [et al.] // Nutriens. –2014. – Vol. 6, № 2. – P. 790–798.
13. Stanley W.C. Review myocardial substrate metabolism in the normal and failing heart / W.C. Stanley, F.A. Recchia, G.D. Lopaschuk // Physiol. Rev. – 2005. – Vol. 85. – P. 1093–1129.
14. Subclinical Cardiovascular Damage and Fat Utilization in Overweight/Obese Individuals Receiving the Same Dietary and Pharmacological Interventions / T. Montalcini, L.T. Lamprinoudi[et al.] // Nutrients. – 2014. – Vol. 6, № 12. – P. 5560–5571.
15. Targeting fatty acid and carbohydrate oxidationa novel therapeutic intervention in the ischemic and failing heart / J.S. Jaswal, W. Keung [et al.] // BiochimBiophysActa. – 2011. – Vol. 1813, № 7. – P. 13331350.
16. World Health Organization. Global atlas on cardiovascular disease prevention and control.– Geneva: World Health Organization, 2011.
Review
For citations:
Pavlyuk N.B., Sharafetdinov H.H., Chedia E.S. Features of Metabologram at Patients with Coronary Heart Disease and Obesity. Yakut Medical Journal. 2015;(3):78-81.
                    
        







