The characteristic of expression of BCL-2 and BAX apoptosis regulatory proteins in lungs with the development of HIV/TB co-infection
Abstract
In this study increase of expression Bcl-2 in zones of granulomatous inflammation and in lung parenchyma is revealed as well as an increasing rate of Bax-positive cells with change in the ratio of expression Bcl-2/Bax (coefficient of apoptosis). The balance pro- and antiapoptotic proteins of Bcl-2 family defines sensitivity of the cell to proapoptotic incentives that indicates activation of anti-apoptotic mechanisms in infected cells at VICh/TB coinfecton.
About the Authors
L. S. Bykhalov
Volgograd state medical university
Russian Federation
Russian Federation
Leonid S. Bykhalov - assistant to the department of pathological anatomy of the Volgograd state medical university, cand. med. sciences, doctoral candidate.
Volgograd, square of Fallen Strugglers, 1, 400131
A. V. Smirnov
Volgograd state medical university
Russian Federation
Russian Federation
Alexey V. Smirnov - head of the pathological anatomy of the Volgograd state medical university, doct. med. sciences, professor.
Volgograd, square of Fallen Strugglers, 1, 400131
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Review
For citations:
Bykhalov L.S., Smirnov A.V. The characteristic of expression of BCL-2 and BAX apoptosis regulatory proteins in lungs with the development of HIV/TB co-infection. Yakut Medical Journal. 2015;(2):54-56.
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