Chronic Inflammatory Demyelinating Polyneuropathy in a Patient with Charcot‐ MARIE‐Tooth (CMT) Disease Type 1A: Case Report
Abstract
We report a patient with chronic inflammatory demyelinating polyneuropathy (CIDP) developed against hereditary motor‐sensory polyneuropathy (Charcot‐Marie‐Tooth disease type 1A). It is shown that the presence of chronic persistent herpes infection, stratifying on the mutation in the gene PMP22 (peripheral myelin protein), may lead to the development of autoimmune process, manifested demyelinating lesions of the peripheral nerves of the limbs and cranial nerves. CIDP – an autoimmune disease characterized by lesions of the myelin sheath of peripheral nerves, it accounts for about 20‐50% of undiagnosed polyneuropathy. The literature discusses the contribution of viruses of the family Herpes Viridae to the development of CIDP. Charcot‐Marie‐Tooth disease (CMT) – a large group of hereditary diseases of the nervous system characterized by chronic progressive weakness and atrophy of distal limb muscles, reduced tendon reflexes, foot deformities and hands, changes in gait and sensory impairments.
About the Authors
T. E. Popova
KrasGMU
Russian Federation
Russian Federation
Popova Tatyana E. ‐ Ph.D., Associate Professor, Department of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education.
660021, ul. Karl Marx 124, Krasnoyarsk
A. A. Tappakhov
North‐Eastern Federal University named after MK Ammosov
Russian Federation
Russian Federation
Tappahov Alexey A. ‐doctor‐neurologist Clinic Medical Institute FSAEI VPO
677000, ul. Oiunsky, d. 27, Yakutsk
T. Y. Nikolaeva
North‐Eastern Federal University named after MK Ammosov
Russian Federation
Russian Federation
Nikolayeva Tatiana Y. ‐ Doctor of Medical Sciences, Head of Department of Neurology and Psychiatry Medical Institute
677000, ul. Oiunsky, d. 27, Yakutsk
N. A. Schnayder
KrasGMU
Russian Federation
Russian Federation
Schneider Natalia A. ‐ MD, Professor, Head of Department of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education KrasGMU
660021, Krasnoyarsk, ul. Karl Marx 124
M. M. Petrova
Красноярский гос. мед. университет
Russian Federation
Russian Federation
Petrova Marina M. ‐ MD, Professor, Head of the Department of outpatient therapy and family medicine postgraduate education KrasGMU
660022, Krasnoyarsk, ul. P. Zheleznyaka, 1
A. Yu. Petrova
GBU Republic Sakha (Yakutia) "Republican Hospital №2‐ Center for Emergency Medical Aid»
Russian Federation
Russian Federation
Petrova Alena Y. ‐ neurologist
677000, Yakutsk, ul. P.Alekseeva 83A
L. T. Okoneshnikova
GBU Republic Sakha (Yakutia) "Republican Hospital №2‐ Center for Emergency Medical Aid»
Russian Federation
Russian Federation
Okoneshnikova Lyudmila T., Head of Neurology department
677000, Yakutsk, ul. P.Alekseeva 83A
D. A. Popov
GBU Republic Sakha (Yakutia) "Republican Hospital №2‐ Center for Emergency Medical Aid»
Russian Federation
Russian Federation
Popov Dygyn A. ‐ doctor of department MRI diagnosis
677000, Yakutsk, ul. P.Alekseeva 83A
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Review
For citations:
Popova T.E., Tappakhov A.A., Nikolaeva T.Y., Schnayder N.A., Petrova M.M., Petrova A.Yu., Okoneshnikova L.T., Popov D.A. Chronic Inflammatory Demyelinating Polyneuropathy in a Patient with Charcot‐ MARIE‐Tooth (CMT) Disease Type 1A: Case Report. Yakut Medical Journal. 2015;(4):106-109.
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