The Cytokine Profile at Children with Juvenile Forms of Arthritis
Abstract
We studied the cytokine profile in children with various forms of juvenile arthritis aged from 0 till 16 years old. The average values of the levels of proinflammatory cytokines (TNF-α, IFN-γ and IL-6) in ten times exceed the upper limit of the normal range. High levels of the proinflammatory cytokine IL-1β significantly correlates with family history of patients, and high levels of anti-inflammatory cytokine IL-10 is observed in patients with juvenile ancylosing spondylitis (JAS).
About the Authors
F. V. Vinokurova
FSSI «Yakut Scientific Center of complex medical problems»
Russian Federation
Russian Federation
Vinokurova Fekla Vasilyevna– junior researcher», the immunopathology laboratory
A. S. Golderova
FSSI «Yakut Scientific Center of complex medical problems»
Russian Federation
Russian Federation
Golderova Aytalina Semenovna – MD, Head», the immunopathology laboratory
S. D. Efremova
FSSI «Yakut Scientific Center of complex medical problems»
Russian Federation
Russian Federation
Efremova Svetlana Dmitrievna ‐ junior researcher», the immunopathology laboratory
O. G. Tikhonova
FSSI «Yakut Scientific Center of complex medical problems»
Russian Federation
Russian Federation
Tikhonova Olga Gavrilievna ‐ junior researcher The North‐Eastern Federal University
L. V. Grigorieva
North‐Eastern Federal University
Russian Federation
Russian Federation
Grigorieva Lena Valerievna – leading research worker of the RC of applied ecology
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Review
For citations:
Vinokurova F.V., Golderova A.S., Efremova S.D., Tikhonova O.G., Grigorieva L.V. The Cytokine Profile at Children with Juvenile Forms of Arthritis. Yakut Medical Journal. 2015;(4):83-85.
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