Possibilities of neuroimaging markers in the diagnosis of Parkinson's disease
https://doi.org/10.25789/YMJ.2022.77.24
Abstract
The review summarizes the results of studies on applying the principle of neuroimaging for the early diagnosis of Parkinson's disease (PD). The term "neuroimaging" combines various methods of direct or indirect displaying the structure, functions and biochemical characteristics of the nervous system. In-dication of specific defects in brain structures has become possible due to such methods as positron emission tomography, single photon emission computed tomography, transcranial sonography in B-mode, MRI of the brain in SWI mode, and neuromelanin-sensitive MRI (NM-MRI). The ocular component of neuroimaging in PD may be associated with the study of the structural and functional state of various neuroelements of the eye, in particular, with the as-sessment of the state of the corneal nerve fibers (CNF). The difficulties of con-ducting research in this area of neuroimaging may be associated not only with the reliable detection of CNF changes in PD, but also with the assessment of the specificity of these changes, taking into account their potential polyetiolo-gy.
About the Authors
S. E. Avetisov
Sechenov 1st Moscow Medical University, Eye Diseases Research Institute
Russian Federation
Russian Federation
Avetisov Sergey Eduardovich – academician of the Russian Academy of Sciences, Professor, Ph.D.
S. N. Illarioshkin
Federal State Budgetary Institution Neurology Scientific Center, the laboratory of neural cerebral structures; FBHNU NTN
Russian Federation
Russian Federation
Illarioshkin Sergey Nikolayevich – corresponding member, RAS, Ph.D.M., Prof, deputy director of science, chief coordinator of the 5th neurol. department
Z. V. Surnina
Eye Diseases Research Institute
Russian Federation
Russian Federation
Surnina Zoya Vasilyevna – Candidate of Medical Sciences, senior researcher,
S. Georgiev
Yakut Republican Ophthalmologic Clinic
Russian Federation
Russian Federation
Georgiev Stefan – PhD student of the Eye Diseases Research Institute, ophthalmologist
Yakutsk
A. N. Moskalenko
Eye Diseases Research Institute
Russian Federation
Russian Federation
Moskalenko Anna Nikolayevna – neurologist, postgraduate student
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Review
For citations:
Avetisov S.E., Illarioshkin S.N., Surnina Z.V., Georgiev S., Moskalenko A.N. Possibilities of neuroimaging markers in the diagnosis of Parkinson's disease. Yakut Medical Journal. 2022;(2):92-96. https://doi.org/10.25789/YMJ.2022.77.24
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