Remaxol in the Correction of Lipid Peroxidation Processes of Biomembranes Induced by the Cold Exposure Authors:
Abstract
In experimental conditions the possibility to correct free radical lipid oxidation of rats’ organism membranes was studied with the introduction of the succinate containing drug called remaxol. The animals were divided into 4 groups and each of them had 30 rats: intact animals which were held in standard conditions of vivarium; the control group in which rats were exposed to cold during three hours daily; the experimental group in which before cooling animals had a daily intake of the remaxol in a dose of 50 mg/kg; the experimental group in which before cooling animals had a daily intake of the remaxol in a dose of 100 mg/kg. It was found out that in the blood of experimental animals a daily cold exposure during three hours contributes to the increase of lipid hydroperoxides level (by 25 – 41%), of diene conjugate (by 38 – 54%), and of malonic dialdehyde (by 27 – 74%) against the decrease of antioxidant system activity in the blood of intact animals.
About the Authors
V. A. Dorovskikh
SBEI HPE Amur State Medical Academy
Russian Federation
Russian Federation
Dorovskikh Vladimir Anatol'evich, Honoured Scientist of the RF., MD, Professor, Head of the Department of Pharmacology
Blagoveshensk
O. N. Li
SBEI HPE Amur State Medical Academy
Russian Federation
Russian Federation
Li Olga Nikolaevna, PhD, Assistant Professor of the Department of Pharmacology
Blagoveshensk
N. V. Simonova
SBEI HPE Amur State Medical Academy
Russian Federation
Russian Federation
Simonova Natalia Vladimirovna, Doctor of Biology, Assistant Professor of the Department of Pharmacology
675000 the Amur Region, Polytekhnicheskaja street, h. 55, fl. 20, Blagoveshensk
M. A. Shtarberg
SBEI HPE Amur State Medical Academy
Russian Federation
Russian Federation
Shtarberg Michael Anatol'evich, PhD, senior Researcher
Blagoveshensk
T. A. Bugreeva
SBEI HPE Amur State Medical Academy
Russian Federation
Russian Federation
Bugreeva Tatyana Andreevna, 4th year Student
Blagoveshensk
References
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Review
For citations:
Dorovskikh V.A., Li O.N., Simonova N.V., Shtarberg M.A., Bugreeva T.A. Remaxol in the Correction of Lipid Peroxidation Processes of Biomembranes Induced by the Cold Exposure Authors:. Yakut Medical Journal. 2015;(4):21-24.
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