Molecular and genetic testing of HLA II class genes in celiac disease patients in Yakutia
Abstract
The article presents the results of molecular genetic study based on typing of class II HLA genes (DRB1, DQA1, DQB1) in patients in age from 8 months to 18 years with a referral diagnosis of celiac disease or with suspected celiac disease. The study of the gene HLA class II with three-locus haplotypes DRB1-DQA1-DQB1 revealed carriers of the haplotypes associated with celiac disease. The researchers found a high frequency of carriers of the haplotypes DRB1*04 - DQA1*03:01 - DQB1*03:02 (DQ8 type) in the Yakuts compared to the Russians.
About the Authors
H. A. Kurtanov
FGBNU YSC CMP
Russian Federation
Russian Federation
Hariton A. Kurtanov ‐ junior researcher Division of Molecular Genetics
977019, Sergelyakh Highway 4, Yakutsk
A. L. Danilova
FGBNU YSC CMP
Russian Federation
Russian Federation
Anastasia L. Danilova ‐ PhD, researcher Division of Molecular Genetics
A. E. Yakovleva
Ammosov NEFU
Russian Federation
Russian Federation
Alexandra E. Yakovleva ‐ junior researcher; Educational and Research Laboratory "Genomic Medicine" MI
V. V. Gerasimova
Ammosov NEFU
Russian Federation
Russian Federation
Vilena V. Gerasimova – researcher; Educational and Research Laboratory "Genomic Medicine" MI
A. D. Savvina
GBU Sakha (Yakutia), "Children's City Hospital"
Russian Federation
Russian Federation
Anastasia D. Savvina ‐ PhD, Head of Dep.
N. R. Maximova
Ammosov NEFU
Russian Federation
Russian Federation
Nadezhda R. Maximova – MD,Head of the Lab; Educational and Research Laboratory "Genomic Medicine" MI
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Review
For citations:
Kurtanov H.A., Danilova A.L., Yakovleva A.E., Gerasimova V.V., Savvina A.D., Maximova N.R. Molecular and genetic testing of HLA II class genes in celiac disease patients in Yakutia. Yakut Medical Journal. 2015;(4):5-7.
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