Morphological features of endothelial cover of pulmonary artery and aorta at fetuses and newborns after chronic intrauterine hypoxia (an experimental study)
Abstract
Morphological features of pulmonary artery and aorta in fetuses and newborns have been studied in order to determine morphological changes in endothelial cover of the pulmonary artery and the aorta in fetuses and newborns affected by chronic fetal hypoxia (CFH) as a result of the experiment on laboratory WAG rats on modeling fetal hypoxia of newborns with asphyxia in delivery. According to results of the research in the pulmonary artery and the aorta of fetuses and newborns affected by CFH deterioration of trophic processes in the endotheliocyte has been found due to thickening of basal membranes. It causes cells flattening, decrease of adhesive properties which is evidenced by decreased expression of receptors CD 34 by endothelium, and their desquamation amplification. Also sclerotic changes in the basal membranes of both vessels have been also determined due to interstitial collagen type III appearance against type IV collagen deficiency.
About the Authors
V. D. Markovsky
Kharkov National Medical University
Ukraine
Ukraine
Vladimir D. Markovsky – MD, professor, professor of Pathological Anatomy department, vice-rector for research and education.
4, Lenina avenue, 61022, Kharkov
I. V. Sorokina
Kharkov National Medical University
Ukraine
Ukraine
Irina V. Sorokina – MD, professor, professor of Pathological Anatomy department, acting head of Pathological Anatomy department.
4, Lenina avenue, 61022, Kharkov
O. V. Kaluzhina
Kharkov National Medical University
Ukraine
Ukraine
Oksana V. Kaluzhina – graduate student of Pathological Anatomy department.
4, Lenina avenue, 61022, Kharkov
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Review
For citations:
Markovsky V.D., Sorokina I.V., Kaluzhina O.V. Morphological features of endothelial cover of pulmonary artery and aorta at fetuses and newborns after chronic intrauterine hypoxia (an experimental study). Yakut Medical Journal. 2015;(2):33-35.
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