Features of the Functional State of Vascular Endothelium in Elderly Patients after Splenectomy
Abstract
We studied functional state of arterial wall endothelium in elderly patients after splenectomy due to trauma of spleen in close post-operational period. Data showed that antithrombotic features of endothelium has changed heterogeneously, i.e. intensification of fibrinolytic activity due to low thromboresistance of endothelium, which is accompanied by reduced tissue plasminogen activator (tPA) in vascular wall and reduced secretion of it to bloodstream. This data suggests that certain biologically active substances are secreted by spleen, which facilitates release of tPA from endothelium, which in turn can lead to intravascular thrombus formation in these group of patients.
About the Authors
V. V. Maslyakov
NOU VPO "Saratov Medical Institute" REAVIZ "
Russian Federation
Russian Federation
Maslyakov Vladimir Vladimirovich – MD, prof., Vice President of Research and PublicRelations, Head of the department
Saratov
V. G. Barsukov
NOU VPO "Saratov Medical Institute" REAVIZ "
Russian Federation
Russian Federation
Barsukov Vitaly Gennadievich - PhD, Assistant of the Department
Saratov
A. P. Tabunkov
NOU VPO "Saratov Medical Institute" REAVIZ "
Russian Federation
Russian Federation
Tabunkov Andrei Pavlovich - graduate student
Saratov
References
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Review
For citations:
Maslyakov V.V., Barsukov V.G., Tabunkov A.P. Features of the Functional State of Vascular Endothelium in Elderly Patients after Splenectomy. Yakut Medical Journal. 2014;(4):14-16.
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