Comparative Evaluation of Antioxidant Activity of Cytoflavin in Various Doses in the Conditions of Cold stress
Abstract
The article reports results of study of the cytoflavin effect in doses of 50 mg / kg and 100 mg / kg on the antioxidant status of rats at chronic cold exposure. It was established that the studied preparation prevented from stress-induced activity of lipid peroxidation in serum of the animals, exposed to cold. The effect is expressed in less formation of peroxidation products and in the prolonged conservation of a high level of antioxidant system components activity. During the comparative pharmacological analysis it was established that cytoflavin produced a direct antioxidant effect according to a dose during cold exposure on the organism of the experimental animals.
About the Authors
V. A. Dorovskikh
SBEI HPE Amur State Medical Academy
Russian Federation
Russian Federation
Dorovskikh Vladimir Anatol'evich, Honoured Scientist of R.F., Doc. of Med. Sc., Professor, Head of the Department of Pharmacology
official tel. 8 4162 319011
O. N. Li
SBEI HPE Amur State Medical Academy
Russian Federation
Russian Federation
Li Olga Nikolaevna, Cand. of Med. Sc., senior laboratory assistant Head of the Department of Pharmacology
cell tel. 89248482344
N. V. Simonova
SBEI HPE Amur State Medical Academy
Russian Federation
Russian Federation
Simonova Natalia Vladimirovna, Doc. of Biol. Sc., Assistant Professor of the Department of Pharmacology
675000 the Amur Region, c. Blagoveshchensk, Polytekhnicheskaja street, h. 55, fl. 20
official tel. 8 4162 319015
home tell. 8 4162 373472
cell tell. 89246768166
M. A. Shtarberg
SBEI HPE Amur State Medical Academy
Russian Federation
Russian Federation
Shtarberg Michael Anatol'evich, Cand. of Med. Sc., senior Research worker
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Review
For citations:
Dorovskikh V.A., Li O.N., Simonova N.V., Shtarberg M.A. Comparative Evaluation of Antioxidant Activity of Cytoflavin in Various Doses in the Conditions of Cold stress. Yakut Medical Journal. 2014;(4):4-7.
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