Association of ACE gene polymorphism with hypertension and risk factors among indigenous people of the northern territory of Yakutia
https://doi.org/10.25789/YMJ.2018.64.29
Abstract
A study of the association of insertion-deletion (ID) polymorphism of the ACE gene with arterial hypertension and risk factors of cardiovascular diseases in the indigenous people of the northern territory of Yakutia was conducted. The obtained data show that the representatives of the indigenous population with the ID genotype of the ACE gene are associated with a level of systolic blood pressure, abdominal obesity. Carriers of this genotype of the ACE gene have the greatest chance of developing hypertension, metabolic syndrome. The heterozygous DD genotype is associated with lipid metabolic disorders both in hypertensive patients and persons without hypertension. Therefore, the research confirms influence of the D allele ACE gene polymorphism onto genetic mechanisms of cardiovascular diseases development.
About the Authors
S. I. Sofronova
YSC CMP
Russian Federation
Russian Federation
Sofronova Sargylana Ivanovna, PhD, researcher
Sergelyahskoe shosse 4, Yakutsk, Republic Sakha (Yakutia)
A. N. Romanova
YSC CMP
Russian Federation
Russian Federation
Romanova Anna Nikolaevna, MD, director
Sergelyahskoe shosse 4, Yakutsk, Republic Sakha (Yakutia)
N. V. Mikhailovich
YSC CMP
Russian Federation
Russian Federation
Nikolaev Viacheslav Mikhailovich, PhD, researcher of YSC CMP
Sergelyahskoe shosse 4, Yakutsk, Republic Sakha (Yakutia)
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Review
For citations:
Sofronova S.I., Romanova A.N., Mikhailovich N.V. Association of ACE gene polymorphism with hypertension and risk factors among indigenous people of the northern territory of Yakutia. Yakut Medical Journal. 2018;(4):96-99. https://doi.org/10.25789/YMJ.2018.64.29
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