Polymorphism of the NOS3 gene in the Yakut population
https://doi.org/10.25789/YMJ.2019.68.04
Abstract
The study of polymorphism rs1799983 of the NOS3 gene in healthy individuals in the Yakut population was carried out. Genotyping revealed the predominance of the G allele among the Yakut population. Analysis of the frequency of occurrence of the genotypes of the polymorphic variant rs1799983 of the NOS3 gene revealed that carriers of the homozygous GG genotype prevailed among all examined individuals (83.56%). Thus, the study of polymorphism rs1799983 of the NOS3 gene in various ethnic groups may have the prospect of developing personalized medicine to predict fibrotic changes in the liver.
Keywords
nitric oxide synthase 3 gene,
nitric oxide,
polymorphism,
NOS3,
G894T,
endothelial dysfunction,
liver fibrosis,
Yakut population
Supporting agencies: The study was carried out within the framework of the research project Study of the genetic structure and burden of congenital defects of the populations of the Sakha Republic (Yakutia) using the UNU "Genome of Yakutia" (reg. No. USU_507512). The research was carried out with the support of Innovation Promotion Fund (Agreement No. 13755GU / 2018 dated 02.04.2019 (code 0045258), application No. 53541, competition UMNIK-18 (a), Sakha Republic (Yakutia) – 2018).
About the Authors
Yu. A. Solovyova
Federal State Autonomous Educational Institution of Higher Education "M. K. Ammosov North-Eastern Federal University"
Russian Federation
Russian Federation
Solovyova Yulia Alekseevna – postgraduate student of "Normal and Pathological Physiology" department, Senior Lecturer of “Advanced therapy, occupational diseases and clinical pharmacology” department
27 Oyunskogo Street Yakutsk, 677000. Office number: +7 (914) 276-71-20
Kh. A. Kurtanov
Yakut Science Centre of complex medical problems
Russian Federation
Russian Federation
Kurtanov Khariton Alekseyevich – Candidate of Medical Sciences, Chief researcher, Head of Department of Molecular Genetics
4 Sergelyakhskoye shosse Yakutsk, 677000. Office number: (4112) 32-19-81
N. I. Pavlova
Yakut Science Centre of complex medical problems
Russian Federation
Russian Federation
Pavlova Nadezhda Ivanovna – Candidate of Biological Sciences, leading researcher, Head of Hereditary Pathology laboratory
4 Sergelyakhskoye shosse Yakutsk, 677000. Office number: (4112) 32-19-81
N. A. Solovyova
Yakut Science Centre of complex medical problems
Russian Federation
Russian Federation
Solovyova Natalya Alekseevna – Candidate of Medical Sciences, leading researcher
4 Sergelyakhskoye shosse Yakutsk, 677000. Office number: (4112) 32-19-81
N. V. Borisova
Federal State Autonomous Educational Institution of Higher Education "M. K. Ammosov North-Eastern Federal University"
Russian Federation
Russian Federation
Borisova Natalya Vladimirovna – Doctor of Medical Sciences, Professor of "Normal and Pathological Physiology" department, Medical Institute
27 Oyunskogo Street Yakutsk, 677000. Office number: +7 (4112) 36-30-46
S. S. Sleptsova
Federal State Autonomous Educational Institution of Higher Education "M. K. Ammosov North-Eastern Federal University"
Russian Federation
Russian Federation
Sleptsova Snezhana Spiridonovna – Doctor of Medical Sciences, Professor of "Infectious diseases, phthisiology and dermatovenereology" department, Medical Institute
27 Oyunskogo Street Yakutsk, 677000. Office number: +7 (4112) 43-22-25
A. T. Dyakonova
YSC CMP
Russian Federation
Russian Federation
Dyakonova Alexandra Timofeevna – Ph.D. lab. hereditary pathology of the Department of Molecular Genetics
kt. 8-964-077-78-29
T. N. Alexandrova
YSC CMP
Russian Federation
Russian Federation
Alexandrova Tuyara Nikonovna – M.S. lab. hereditary pathology of the Department of Molecular Genetics
kt 8-924-874-81-34
N. P. Filippova
YSC CMP
Russian Federation
Russian Federation
Filippova Natalya Pavlovna – candidate. biol. sciences., senior researcher lab. hereditary pathology of the Department of Molecular Genetics
Ph.D. 8-914-303-43-95
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Review
For citations:
Solovyova Yu.A., Kurtanov Kh.A., Pavlova N.I., Solovyova N.A., Borisova N.V., Sleptsova S.S., Dyakonova A.T., Alexandrova T.N., Filippova N.P. Polymorphism of the NOS3 gene in the Yakut population. Yakut Medical Journal. 2019;(4):19-22. https://doi.org/10.25789/YMJ.2019.68.04
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