Serological and molecular-biological verification of viral hepatitis B, C, D and E in various populations of the Republic Sakha (Yakutia)

The purpose of the study is the serological and molecular-biological monitoring of the latitude of viral hepatitis B, C, D and E in the Republic of Sakha (Yakutia).

Materials and methods. Used official statistics and annual reports. The analysis of the incidence of acute and chronic viral hepatitis B and C, hepatitis carriers for the period from 1999 to 2016, as well as serological and molecular biological monitoring of the latitude of viral hepatitis B, C, D and E in the Republic of Sakha (Yakutia).

Results and discussion. In the dynamics of the incidence of AVG B, the carriage of VGV and VG C in Yakutia, there is no existence of any of their own laws that are not inherent in many regions of Russia. In general, based on the level and dynamics of the incidence of chronic viral hepatitis In the country, it is possible to characterize the overall epidemiological situation as unfavorable, even despite a noticeable decrease in the incidence. The unstable undulating nature of the incidence and their increase in recent years indicate the persistence of epidemiological tension with respect to viral hepatitis B. A distinctive feature of the structure of chronic viral hepatitis in the Republic of Sakha (Yakutia) is the high incidence of chronic viral hepatitis B and the steady growth of chronic viral hepatitis C. The infection of the population of the Republic with hepatitis B and C viruses can be determined as high. This situation, given the high frequency and severity of the adverse effects of HBV, HCV infections, as well as the endemicity of HDV infection, poses a threat to public health. According to the results of serological, molecular biological studies, a high incidence and infection rate of the population of the republic with all known hepatitis viruses was stated. An increased circulation of hepatitis E virus, previously considered a tropical infection, was also detected in the Arctic zone of Russia.

Conclusion. In general, an epidemiological analysis of the incidence of acute and chronic viral hepatitis showed that in the Republic of Sakha (Yakutia) a highly endemic area with respect to viral hepatitis C, B, D and E, and such a tense epidemiological situation requires urgent appropriate measures. Studies of the genetic heterogeneity of the identified hepatitis viruses and the pathogenetic mechanisms of the development of the disease among the indigenous people of the Russian North are also required.

1. Infectious hepatology: a guide for doctors / V.F.Uchajkin, T.V. Cherednechenko, A.I. Smirnov. – M.: GEOTAR-Media, 2014. – P.154.

2. Keregyan K.K. Molecular-biological basis for the control of viral hepatitis / K.K. Keregyan: MD thesis. – M., 2012.

3. Kuzin S.N. Assessing the incidence and etiological structure of acute and chronic viral hepatitis in the territory of the Republic of Sakha (Yakutia) / S.N.Kuzin // Virology issues. – 2004. – V.49. - №1. – P. 20-23.

4. Mixajlov M.I. Enteral virus hepatitis (etiology, epidemiology, diagnosis, prevention)/ M.I. Mixajlov, I.V. Shaxgil`dyan., G.G. Onishhenko.– M.: VUNMCz Roszdrava, 2007.

5. Pavlov N.N. Epidemiological characteristics of viral hepatitis B, delta and C in the Republic of Sakha (Yakutia): PhD thesis // N.N. Pavlov. – 2004. – 28 p.

6. Potemkin I.A. The prevalence of hepatitis E markers in children / I.A. Potemkin //Journal of Microbiology, Epidemiology and Immunobiology. – 2016. – №2. – p. 38-45.

7. Semenov S.I. Epidemiological features and clinical characteristics of viral hepatitis B, C and Delta in the Republic of Sakha (Yakutia) / S.I. Semenov MD thesis. – M., 2007. – 48 p. 8.

8. Solonin S.A. Circulation of viral hepatitis E among pigs in the territory of the Russian Federation / S.A. Solonin: PhD thesis. – M., 2010.

9. Berkes J. Global Epidemiology of HCV Infection / J. Berkes, S.J. Cotler // Current Hepatitis Report, 2005, vol. 4, pp. 125–129. DOI:10.1016/S1473-3099(05)70216-4

10. Cross-species infections of cultured cells by hepatitis E virus and discovery of an infectious virus-host recombinant / P. Shukla, H.T. Nguyen, U. Torian [et al.] / Proc Natl Acad Sci US A. 2011 Feb 8;108(6):2438-43. DOI: 10.1073/pnas.1018878108.

11. Dalton H.R. Hepatitis E in developed countries: current status and future perspectives / H.R. Dalton, N. Kamar, J. Izopet // Future Microbiol. 2014; 9(12):1361-72. DOI: 10.2217/fmb.14.89.

12. Epidemiology of Hepatitis E Virus in European Countries / D. Lapa, M.R. Capobianchi, А.Р. Garbuglia [et al.] // Int J Mol Sci. 2015 Oct 27;16(10):25711-43. DOI: 10.3390/ijms161025711.

13. Genotype-4 hepatitis E in a human after ingesting roe deer meat in South Korea. / J.Y. Choi, J.M. Lee, Y.W. Jo [et al.] / Clin Mol Hepatol. 2013 Sep;19(3):309-14. DOI: [10.3350/cmh.2013.19.3.309]

14. Hepatitis E like virus found in Swedish moose / J. Lin, H. Norder, H. Uhlhorn [et al.] / J. Gen Virol. 2014 Mar;95(Pt 3):557-70. DOI: 10.1099/vir.0.059238-0}

15. Hepatitis E virus antibody prevalence in hunters from a district in Central Germany, 2013: a cross-sectional study providing evidence for the benefit of protective gloves during disembowelling of wild boars / A.Schielke, V. Ibrahim, I. Czogiel [et al.] // BMC Infect Dis.2015 Oct 22;15:440. DOI: [10.1186/s12879-015-1199-y]

16. Hepatitis E virus infection among domestic animals in eastern China. Zoonoses / W. Zhang, Q. Shen, J. Mou [et al.] // Public Health. 2008 Aug;55(6):291-8.

17. Ivaniushina V.A. Geographic distribution of Hepatitis D virus (HDV) genotype II in Yakoutia (Russia)/ V.A. Ivaniushina, R. Radjef, S.I. Semenov // Hepatology, suppl. October 1999.

18. Khuroo M.S. Hepatitis E: an emerging global disease - from discovery towards control and cure / M.S. Khuroo // J Viral Hepat. 2015 Sep 6. DOI: 10.1111/jvh.12445

19. Parenteral viral hepatitis (V, S, D) in the Sakha Republic (Yakutia) / S.I. Semjonov, R.G. Savvin, S.G. Nikitina [et al.] / Life Science Journal 2014;11(8s). R.454-458.

20. Perez-Garcia M.T., Modern knowledge about hepatitis E / M.T Perez-Garcia., B.Suay, M.L.Mateos-Lindemann // Int. J Mol. Sci..2015 Oct; 16 (10): 25711-43. DOI:10.1016/j.meegid.2014.01.002

21. The past incidence of hepatitis C virus infection: implications for the future burden of chronic liver disease in the United States / G.L Armstrong., M.J. Alter, G.M.McQuillan, [et al.] // Hepatology. 2000;31: Р. 777–782. DOI:10.1002/hep.510310332.