Comparative study of reparative regeneration of the oral mucosa in experiment

Abstract

At present, treatment of inflammatory-destructive diseases of the oral cavity is still a relevant problem. Despite the fact that any dentist disposes a wide range of medical preparations, it is difficult to choose one with the least amount of complications. While managing elderly patients with dental problems the goal is not only to facilitate healing of the oral mucosa, but also to prevent the recurrence of pathology. Injections of platelet autoplasma may be useful in treatment of inflammatory-destructive diseases of the maxillofacial region. Injections of platelet autoplasma for inflammatory-destructive diseases of the oral mucosa, effect of synergism of this method in combination with other therapeutic means justify the need for further study of this issue. In this work, in order to study the regenerative potential, the simulated wound defect in the oral cavity of 30 dogs was treated experimentally. Regeneration control, treatment and supervision lasted 14 days alongside with application of various pharmacotherapeutical methods. To exclude additional factors which might affect the final result of the experiment associated with individual physiological features, study of experimental local treatment methods was carried out within one body: traditional methods of treatment; application of Tysol composition with L-arginine; injections of platelet autoplasma were included in the treatment plan as well as a combined method of treatment. Platelet autoplasma injections combined with Tizol applications with L – arginine was proved to help restore and heal the oral mucosa much faster comparing to other treatment methods.