Gamma background environment during magnetic storms and the contents of sodium and potassium in erythrocytes in patients with arterial hypertension depending on the temperament and antihypertensive therapy

Arterial hypertension is one of the major independent risk factors for complications of cardiovascular diseases, stroke, myocardial infarction, acute and chronic heart failure. In the structure of cardiovascular diseases arterial hypertension occupies the first position in disability and mortality of the working population. In recent years, this contributes to the growth of psycho-emotional stress, anxiety and depression. Periods of sharp changes heliometeofactors also combined with an increase in the proportion of individuals with complications of hypertension. Thus, in the period of magnetic storms, there was an increase in gamma radiation power (within the regional norm), an increase in the degree of psycho-emotional stress and a change in the concentration of electrolytes in the blood of both healthy and persons with cardiovascular disease. The aim of the study was to establish the relationship between the dynamics of γ-background of the environment during magnetic storms and the content of potassium and sodium in red blood cells in patients with hypertension with different temperament and anxiety, taking options for antihypertensive therapy: targeted and not targeted (empirical) on the blockade of psychosomatic characteristics of patients, as well as to determine the most effective treatment option. The prevailing temperament – choleric, sanguine, phlegmatic and melancholy – was determined using the psychological test of John Eysenck and A. Belov, the presence and severity of depression – Je. Ahmetzhanov psychological tests. Potassium and sodium content in erythrocytes was determined by ion-selective method. The gamma background of the medium was measured using the dosimeter «Master».

It was found that the decrease in the activity of the sympathetic Department of the autonomic nervous system and the hypothalamic-pituitaryadrenal system (cortisol), and the increase in the activity of the renin-angiotensin-aldosterone system (aldosterone) in the temperamental series of choleric – sanguine – phlegmatic – melancholy was combined with a decrease in the level of oxygen utilization by tissues and potassium content in erythrocytes and an increase in sodium content in both healthy and patients. Compared with the empirical version of antihypertensive therapy, against the background of a targeted treatment option, the period of return of the values of the studied parameters, the level of oxygen utilization by tissues, the content of potassium and sodium in erythrocytes, as well as the degree of reaction of the body (according to the correlation analysis) were practically the same as in healthy individuals of the corresponding temperament, which indicates in favor of a higher efficiency of the treatment option targeted at the relief of psychosomatic features of the patient.

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