Анализ клинического течения гастродуоденальных заболеваний в Якутии в зависимости от наличия цитотоксинассоциированного гена А (cagA) в геноме Helicobacter pylori

В статье приводятся результаты изучения клинического течения гастродуоденальных заболеваний в Якутии в зависимости от наличия цитотоксин-ассоциированного гена а (cagA) в геноме Helicobacter pylori. Показана связь между cagA+ штаммами и более тяжелым клиническим течением гастродуоденальных заболеваний (эрозивно-язвенные поражения) у пациентов с Helicobacter pylori в Якутии.

1. Новиков Д.К. Клиническая иммунология: учебное пособие / Д.К. Новиков, П.Д. новиков. ВГМУ, 2006. – С. 392.

2. Association of cagA and vacA Genotypes of Helicobacter pylori with gastric diseases in Estonia / H. Andreson, K. Lõivukene, T. Sillakivi [et al.] // J Clin Microbiol. – 2002. – 40. – P. 298-300.

3. Association of Helicobacter pylori cagA Gene with Gastric Cancer and Peptic Ulcer in Saudi Patients / T. Saber, M.M. Ghonaim, A.R. Yousef [et al.] // J Microbiol Biotechnol. – 2015 Jul – 5(7) – P.146-53.

4. Biofilm and Helicobacter pylori: From environment to human host / A. García, M.J. Salas-Jara, C. Herrera [et al.] // World Journal of Gastroenterology. – 2014. – WJG. – 20(19). – P.5632-5638.

5. Blaser M.J. Ecology of Helicobacter pylori in the human stomach / Blaser M.J. // J Clin Invest. – 1997. – 100. – P. 759-762.

6. Clinical relevance of H. pylori cagA and vacA gene polymorphisms / D. Basso, C.F. Zambon, D.P. Letley [et al.] // Gastroenterology. – 2008. – 135. – P. 91-99.

7. Clinical Relevance of the cagA, vacA, and iceA Status of H. pylori / L.J. van Doorn, C. Figueiredo, R. Sanna [et al.] // Gastroenterology. – 1998. – 115(15). – P. 58-66.

8. Clinical relevance of the H. pylori gene for blood-group antigen-binding adhesin / M. Gerhard, N. Lehn, N. Neumayer [et al.] // Proc Natl Acad Sci U S A. – 1999. – 96. – P. 12778-12783.

9. Effective Methods of Nucleic Acids extraction for Analysis in Molecular Biology (review) / O.S. Antonova, N.A. Korneva, Yu. V. Belov [et al.] // Scientific Instrument Making. – 2010. – T. – 20. – № 1. – P. 3-9.

10. Functional analysis of iceA1, a CATGrecognizing restriction endonuclease gene in H. pylori / Q. Xu, R. D. Morgan, R. J. Roberts [et al.] // Nucleic Acids Research. – 2002. – 30(17). – P.3839-3847.

11. Helicobacter pylori genotypes among patients in a university hospital in Egypt: identifying the determinant of disease severity / F.A. Amer, R.H. El-Sokkary, M. Elahmady [et al.] // J. Microbiol. Infect. – 2013. – Dis. – 3. – P. 109-115.

12. Helicobacter pylori genotypes and expression of gastritis in erosive gastro-oesophageal reflux disease / A. Leodolter, K. Wolle, U. Peitz [et al.] // Scand J Gastroenterol. – 2003. – 38: 498-502.

13. Helicobacter pylori genotypes are associated with clinical outcome in Portuguese patients and show a high prevalence of infections with multiple strains / C. Figueiredo, L.J. van Doorn, C. Nogueira [et al.] // Scand J Gastroenterol. – 2001 Feb. – 36(2). – P. 128-135.

14. Helicobacter pylori iceA, clinical outcomes, and correlation with cagA: a meta-analysis / S. Shiota, M. Watada, M. Osamu [et al.] // PLoS ONE. – 2012. – 7(1):e30354.

15. Helicobacter pylori strain types and risk of gastric cancer: a case-control study / H. Enroth, W. Kraaz, L. Engstrand [et al.] // Cancer Epidemiol Biomarkers Prev. – 2000 Sep. – 9(9). – P. 981-985.

16. Helicobacter pylori vacA, iceA and cagA status and pattern of gastritis in patients with malignant and benign gastroduodenal disease / S. Miehlike, M. Schuppler, C. Frings [et al.] // Am J Gastroentrol. – 2001. – 96. – P. 1008-1013.

17. Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production / Y. Yamaoka, S. Kikuchi, H.M. el-Zimaity [et al.] // Gastroenterology. – 2002 Aug. – 123(2). – P. 414-24.

18. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach / M.J. Blaser, G.I. Perez-Perez, H. Kleanthous [et al.] // Cancer Res. – 1995. – May 15. – 55(10). – P. 2111-5.

19. Jenks P.J. Clinical outcome after infection with Helicobacter pylori does not appear to be reliably predicted by the presence of any of the genes of the cag pathogenicity island / P.J. Jenks, F. Megraud, A. Labigne // Gut. – 1998. – 43. – P. 752-758.

20. Kusters J.G. Pathogenesis of Helicobacter pylori Infection / J.G. Kusters, A.H.M. van Vliet, E.J. Kuipers // Clinical Microbiology Reviews. – 2006. – 19(3). – P. 449-490.

21. Momenah A.M. H. pylori cagA and iceA genotypes status and risk of peptic ulcer in Saudi patients / A.M. Momenah, M.T. Tayeb // Saudi Med J. – 2007. – 28. – P. 382-385.

22. Prevalence of Helicobacter pylori vacA, cagA, iceA and oipA genotypes in Tunisian patients / K.B. Mansour, C. Fendri, M. Zribi [et al.] // Ann. Clin. Microbiol. Antimicrob. – 2010. – 9. – P. 10-16.

23. Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection / J. Parsonnet, G.D. Friedman, N. Orentreich [et al.]. // Gut. – 1997. – 40(3). – P. 297-301.

24. Rothenbacher D. Helicobacter pylori and gastric cancer / D. Rothenbacher, H. Brenner. // Gastroenterology. – 2004. – Vol.126. – Issue 7. – P.1927.

25. Suerbaum S. H. pylori infection / S. Suerbaum, P. Michetti. // N Engl. J. Med. – 2002. – 347. – P. 1175-1186.

26. The EPIYA-ABCC motif pattern in CagA of Helicobacter pylori is associated with peptic ulcer and gastric cancer in Mexican population / F.O. Beltrán-Anaya, T.M. Poblete, A. Román-Román [et al.] // BMC Gastroenterology. – 2014. – 14:223.

27. Tummuru M.K. Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production / M.K. Tummuru, T.L. Cover, M.J. Blaser // Infect Immun. – 1993 May. – 61(5). – P. 1799-809.

28. Wroblewski L.E. Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk / L.E. Wroblewski, R.M. Peek, K.T Wilson // Clinical Microbiology Reviews. – 2010. – 23(4). – P. 713-739.