Molecular-genetic analysis of the connection of the SLC6A3 gene with nicotine addiction in Yakutia
https://doi.org/10.25789/YMJ.2018.64.01
Abstract
The purpose of this work is to study the relationship of the gene SLC6A3 rs27072 with nicotine addiction in the smoking population living in Yakutia. In total, we examined 100 people (men and women aged 20 to 70 years). The status of smoking was revealed at the questionnaire. Smoking cigarettes, like many other addictives, has a genetic component. The SLC6A3 gene is an important candidate for predisposition to nicotine addiction. Analysis of the polymorphism association of SLC6A3 rs27072 with nicotine addiction testified the absence of statistically significant differences between carriers of different genotypes, not only in the study group as a whole, but also separately in men and women. Probably, this is due to the small sampling and difficulties in determining the status of smoking using only questionnaires.
About the Authors
A. T. Diakonova
YSC CMP
Russian Federation
Russian Federation
D’yakonova Aleksandra Timofeevna – junior researcher of the laboratory of heritable pathology
N. I. Pavlova
YSC CMP
Russian Federation
Russian Federation
Pavlova Nadezhda Ivanovna – PhD, temporary acting chief scientific officer - head of the laboratory of heritable pathology
N. A. Solovyeva
YSC CMP
Russian Federation
Russian Federation
Solov’eva Natal’ya Alekseevna – PhD, temporary acting chief scientific officer - head of the Laboratory of Population Genetics
M. A. Varlamova
YSC CMP
Russian Federation
Russian Federation
Varlamova Marina Alekseevna –researcher of the laboratory of heritable pathology
T. N. Alexandrova
YSC CMP
Russian Federation
Russian Federation
Аleksandrova Tujara Nikonovna - Junior researcher of the laboratory of heritable pathology
Kh. A. Kurtanov
YSC CMP
Russian Federation
Russian Federation
Kurtanov Khariton Alekseevich – PhD, Chief Scientific Officer - Head of the Department of Molecular Genetics
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Review
For citations:
Diakonova A.T., Pavlova N.I., Solovyeva N.A., Varlamova M.A., Alexandrova T.N., Kurtanov Kh.A. Molecular-genetic analysis of the connection of the SLC6A3 gene with nicotine addiction in Yakutia. Yakut Medical Journal. 2018;(4):6-8. https://doi.org/10.25789/YMJ.2018.64.01
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