Indices of lipid metabolism for the early diagnosis of cardiovascular disease in residents of the North
https://doi.org/10.25789/YMJ.2019.67.27
Abstract
Northern climatic factors lead to significant changes in human’s physiological functions based on modified functional condition of the endocrine system, metabolic processes, and lipid metabolism in particular. Adequate assessment and correct interpretation of lipid metabolism variables are of major importance for early detection and timely prevention of cardiovascular pathology. The review considers key lipid metabolism indices. We also present our own data about the role of compound indices in lipid metabolism assessment in healthy inhabitants of the North.
Supporting agencies: The study is supported by the Program for Fundamental Research of RAS (2017-2020), state registration number АААА-А17-117012310157-7.
About the Authors
E. R. Bojko
IPh Komi SC UB RAS, FRC Komi SC UB RAS
Russian Federation
Russian Federation
Bojko Evgeny Rafailovich – Doctor of Medical Sciences, Professor; Head
tel. +7-8212-24- 14-74
A. M. Kaneva
IPh Komi SC UB RAS, FRC Komi SC UB RAS
Russian Federation
Russian Federation
Kaneva Anastasiya Mikhailovna – Doctor in Biological Sciences; Senior Researcher of environmental and medical physiology department
tel. +7-8212-24-14-74
References
1. Averyanova I.V. Lipid and carbohydrate metabolism observed in aboriginal and European students having different terms of residing in the territory of Magadan region / I.V. Averyanova, A.L. Maximov // Human Ecology. – 2015. – № 9. – P. 44-49.
2. Bojko E.R. Apoprotein E and its availability in clinical physiology / E.R. Bojko, A.M. Kaneva // Usp. Fiziol. Nauk. – 2009. – V. 40, № 1. – P. 3-15.
3. Bojko E.R. Physiological and biochemical basis of human vital activity in the North: monograph / E.R. Bojko. – Yekaterinburg: Ural Branch of RAS Publ., 2005. – 190 p.
4. Bojko E.R. Functional importance of apolipoprotein-E in lipid metabolism in inhabitants of the European North / E.R. Bojko, A.M. Kaneva, N.N. Potolitsyna // Human Physiology. – 2010. – V. 36, № 2. – P. 138-144.
5. Leading predictors of the development and further progression of ischemic heart disease among Arctic migrants / E.V. Agbalyan, O.A. Klimenko, M.A. Buyak, E.V. Shynkaruk // Advances in current natural sciences. – 2014. – № 9. – P. 8-10.
6. Darenskaya M.A. Peculiarities of metabolic reactions in indigenous and migrant populations of the North and Siberia / M.A. Darenskaya // Bulletin ESSC SB RAMS. – 2014. – V. 96, № 2. – P. 97-103.
7. Zapesochnaya I.L. Lipid metabolism in the five year observation in healthy persons residing in the North / I.L. Zapesochnaya, A.G. Avtandilov // Medical science and education of the Urals. – 2013. – V. 14, № 3. – P. 23-26.
8. Kaznacheev V.P. Mechanisms of human adaptation in the high latitudes / V.P. Kaznacheev. – Leningrad: Meditsina, 1980. – 200 p.
9. Kaneva A.M. The ratio of low-density lipoprotein cholesterol to apolipoprotein-B as a marker of low-density lipoprotein particle size / A.M. Kaneva, N.N. Potolitsyna, E.R. Bojko // Atherosclerosis. – 2018. – V. 14, № 2. – P. 25-31. DOI: 10.15372/ATER20180204
10. Kaneva A.M. Quantitative distribution of apolipoprotein-Е among blood plasma lipoproteins in healthy men / A.M. Kaneva, N.N. Potolitsyna, E.R. Bojko // Molekulyarnaya meditsina. – 2018. – V. 16, № 5. – P. 51–55. DOI: 10.29296/24999490-2018-05-09
11. Klimov A.N. Lipid and lipoprotein metabolism and its disorder: guide for physicians / A.N. Klimov, N.G. Nikul’cheva. – SPb.: Piter Kom, 1999. – 512 p.
12. Krivoschekov S.G. Structurally functional features of cardiovascular system and metabolic indicators at young inhabitants of Yakutia with the normal and raised level of arterial pressure / S.G. Krivoschekov, I.A. Pinigina, N.V. Maharova // Bulletin SB RAMS. – 2009. – V. 29, № 6. – P. 100-108.
13. The blood lipid profile and the lipid metabolism disorders in indigenous people of Yakutia / T.E. Uvarova, T.E. Burtseva, S.I. Safronova [et al.] // Far East Medical Journal. – 2012. – № 3. – P. 85-88.
14. Serum lipid spectrum of indigenous and non-indigenous population of Yamalo-Nenets autonomous okrug / L.M. Polyakov, A.A. Rozumenko, L.P. Osipova [et al.] // Siberian scientific medical journal. – 2015. – V. 35, № 6. – P. 66-69.
15. Some features of coronary atherosclerosis risk factors in the inhabitants of Yakutia / M.I. Voevoda, A.N. Romanova, Y.I. Ragino, E.V. Semaeva // Bulletin SB RAMS. – 2010. – V. 30, № 3. – P. 52–57.
16. Low levels of apolipoprotein-E as risk factor for increase of apolipoprotein-B/apolipoprotein-AI ratio in healthy men with normolipidemia / A.M. Kaneva, N.N. Potolitsyna, A.Yu. Lyudinina [et al.] // Klin. lab. diagn. – 2014. – V. 59, № 12. – P. 32-36.
17. Panin L.E. Adaptation and a food of the person in extreme conditions of the Arctic / L.E. Panin // Innovation and food security. – 2013. – V. 1, № 1. – P. 131-135.
18. Panin L.E. Man in extreme conditions in the Arctic / L.E. Panin // Bulletin SB RAMS. – 2010. – V. 30, № 3. – P. 92-98.
19. Panin L.E. Energy aspects of adaptation: monograph / L.E. Panin. – Leningrad: Meditsina, 1978. – 192 p.
20. Plyushch M.G. The efficiency of laboratory tests for the diagnosis of lipid metabolic disorders / M.G. Plyushch, N.N. Samsonova // Bulletin SCCVS named after A.N. Bakulev RAMS Cardiovascular diseases. – 2012. – V. 13, № S6. – P. 222.
21. High blood pressure and atherosclerosis in the northern watch / A.S. Vetoshkin, N.P. Shurkevich, L.I. Gapon [et al.] // Arterial Hypertension. – 2018. – V. 24, № 5. – P. 548-555. DOI: 10.18705/1607-419X2018-24-5-548-555
22. Ryabova Т.I. Lipid spectrum’s in blood serum in the natives population (Nanais, Ulchis, Evenks) and new comers of the Amur river region / Т.I. Ryabova, T.V. Popova // Far East Medical Journal. – 2010. – № 4. – P. 106–108.
23. Sevostyanova Ye.V. Some features of human lipid and carbohydrate metabolism in the North / Ye.V. Sevostyanova // Bulletin of Siberian Medicine. – 2013. – V. 12, № 1. – P. 93-100.
24. Cholesterol and risk of atherosclerosis in rural indigenous population of Republic of Sakha (Yakutia) / T.M. Klimova, V.I. Fedorova, M.E. Baltakhinova, V. G. Krivoshapkin // Human Ecology. – 2014. – № 4. – P. 22-27.
25. Tvorogova M.G. Apolipoproteins – properties, determination methods, clinical significance / M.G. Tvorogova // Laboratory medicine. – 2005. – № 7. – P. 29-37.
26. Hasnulin V.I. Lipid metabolism characteristics at the alien inhabitants of the North with arterial hypertension / V.I. Hasnulin, M.M. Gevorgyan, I.A. Bakhtina // World of science, culture, education. – 2011. – V. 29, № 4. – P. 280-283.
27. Apolipoprotein E serum concentration and polymorphism in six European countries: the ApoEurope project / F. Schiele, D. De Bacquer, M. Vincent-Viry [et al.] // Atherosclerosis. – 2000. – V. 152. № 2. – P. 475-488.
28. Apolipoprotein E: an important gene and protein to follow in laboratory medicine / G. Siest, T. Pillot, A. Regis-Bailly [et al.] // Clin. Chem. – 1995. – V. 41. № 8. – P. 1068-1086.
29. Assessment of the validity of the frequently used lipid indices for predicting LDL peak particle diameter in a large cohort of 1955 normal and dyslipidemic subjects / S. Décary, G. Dumont, B. Lamarche [et al.] // Clin. Biochem. – 2010. – V. 43. № 4-5. – P. 401-406. DOI: 10.1016/j.clinbiochem.2009.11.010
30. “Atherogenic index of plasma” (log10 triglyceride/high-density lipoprotein-cholesterol) predicts high blood pressure, diabetes and vascular events / A. Onat, G. Can, H. Kaya, G. Hergenc // J. Clin. Lipidol. – 2010. – V. 4, № 2. – P. 89-98. DOI: 10.1016/j.jacl.2010.02.005
31. Development of approximate formula for LDL-chol, LDL-apo B and LDL-chol/LDL-apo B as indices of hyperapobetalipoproteinemia and small dense LDL / Y. Hattori, M. Suzuki, M. Tsushima [et al.] // Atherosclerosis. – 1998. – V. 138, № 2. – P. 289-299.
32. Dobiasova M. The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL)) / M. Dobiasova, J. Frohlich // Clin. Biochem. – 2001. – V. 34, № 7. – P. 583-588.
33. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study / S. Yusuf, S. Hawken, S. Ounpuu [et al.] // Lancet. – 2004. – V. 364, № 9438. – P. 937-952. DOI: 10.1016/S0140-6736(04)17018-9
34. Kaneva A.M. Usefulness of the LDL-C/ apoB ratio in the overall evaluation of atherogenicity of lipid profile / A.M. Kaneva, N.N. Potolitsyna, E.R. Bojko // Arch. Physiol. Biochem. – 2017. – V. 123, № 1. – P. 16-22. DOI: 10.1080/13813455.2016.1195411
35. LDL particle size by gradient-gel electrophoresis cannot be estimated by LDL-cholesterol/ apolipoprotein B ratios / D. Furuya, A. Yagihashi, S. Nasu [et al.] // Clin. Chem. – 2000. – V. 46, № 8. – P. 1202–1203.
36. LDL-cholesterol/apolipoprotein B ratio is a good predictor of LDL phenotype B in type 2 diabetes / A.M. Wägner, O. Jorba, M. Rigla [et al.] // Acta Diabetol. – 2002. – V. 39, № 4. – P. 215-220. DOI: 10.1007/s005920200037
37. Lipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular prevention / J. Millán, X. Pintó, A. Muñoz [et al.] // Vasc. Health Risk Manag. – 2009. – V. 5, P. 757-765.
38. Mahley R.W. Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS / R.W. Mahley, K.H. Weisgraber, Y. Huang // J. Lipid Res. – 2009. – V. 50 (Suppl), P. S183-188. DOI: 10.1194/jlr.R800069-JLR200
39. Mean platelet volume in relation to carotid atherosclerosis in normotensive, euglycemic, and normolipidemic Chinese middle-aged and elderly adults / H. Ma, H. Lin, Y. Hu [et al.] // Angiology. – 2014. – V. 65, № 6. – P. 512-518. DOI: 10.1177/0003319713520462
40. Noël B. Premature atherosclerosis in patients with xanthelasma / B. Noël // J. Eur. Acad. Dermatol. Venereol. – 2007. – V. 21, № 9. – P. 1244-1248. DOI: 10.1111/j.1468-3083.2007.02252.x
41. Plasma levels of apolipoprotein-E in residents of the European North of Russia / A.M. Kaneva, E.R. Bojko, N.N. Potolitsyna, J.O. Odland // Lipids Health Dis. – 2013. – V. 12, Article Number: 43. DOI: 10.1186/1476-511X-12-43
42. Relationship between triglyceride concentrations and LDL size evaluated by malondialdehyde-modified LDL / A. Kondo, Y. Muranaka, I. Ohta [et al.] // Clin. Chem. – 2001. – V. 47, № 5. – P. 893-900.
43. Small dense low density lipoprotein has increased affinity for LDL receptor-independent cell surface binding sites: a potential mechanismfor increased atherogenicity / N.F. Galeano, M. Al-Haideri, F. Keyserman [et al.] // J. Lipid Res. –1998. – V. 39, № 6. – P. 1263-1273.
44. Sniderman A.D. Putting low-density lipoproteins at center stage in atherogenesis / A.D. Sniderman, T. Pedersen, J. Kjekshus // Am. J. Cardiol. – 1997. – V. 79, № 1. – P. 64-67.
45. Sniderman A.D. The strengths and limitations of the apoB/apoA-I ratio to predict the risk of vascular disease: a Hegelian analysis / A.D. Sniderman, R.S. Kiss // Curr. Atheroscler. Rep. – 2007. – V. 9, № 4. – P. 261-265.
46. Srinivasan S.R. Serum apolipoproteins A-I and B as markers of coronary artery disease risk in early life: the Bogalusa Heart Study / S.R. Srinivasan, G.S. Berenson // Clin. Chem. – 1995. – V. 41, № 1. – P. 159-164.
47. The apolipoprotein B/apolipoprotein A-I ratio as a potential marker of plasma atherogenicity / A.M. Kaneva, N.N. Potolitsyna, E.R. Bojko, J.O. Odland // Disease Markers. – 2015. – V. 2015. – Article Number: 591454. DOI: 10.1155/2015/591454
48. The importance of plasma apolipoprotein E concentration in addition to its common polymorphism on inter-individual variation in lipid levels: results from Apo Europe / N. Haddy, D. De Bacquer, M.M. Chemaly [et al.] // Europ. J. Hum. Genetics. – 2002. – V. 10, № 12. – P. 841-850. DOI: 10.1038/sj.ejhg.5200864
49. Usefulness of serum total cholesterol/triglyceride ratio for predicting the presence of small, dense LDL / A. Yoshida, M. Kouwaki, Y. Matsutani [et al.] // J. Atheroscler. Thromb. – 2004. – V. 11, № 4. – P. 215-219. DOI: 10.5551/jat.11.215
50. Walldius G. The apoB/apoA-I ratio is a strong predictor of cardiovascular risk / G. Walldius; editors S. Frank, G. Kostner // Lipoproteins in Health and Diseases. – Rijeka: InTech, 2012. – P. 95-148.
Review
For citations:
Bojko E.R., Kaneva A.M. Indices of lipid metabolism for the early diagnosis of cardiovascular disease in residents of the North. Yakut Medical Journal. 2019;(3):96-101. https://doi.org/10.25789/YMJ.2019.67.27
Views:
1
Email this article 