The heterogeneity of non-motor symptoms in patients with Parkinson’s disease in Tomsk region
M. A. Nikitina,
N. G. Zhukova,
E. Yu. Bragina,
V. M. Alifirova,
I. A. Zhukova,
D. E. Gomboeva,
N. G. Brazovskaya,
O. P. Izhboldina,
I. Zh. Zhalsanova https://doi.org/10.25789/YMJ.2019.67.20
Abstract
The prevalence of non-motor symptoms (NMS) and the association between various motor and non-motor symptoms and quality of life in patients with Parkinson's disease (PD) in the Tomsk region were studied. Each PD patient had eight different individual NMS on average. The most common among them were constipation, depression, sleep disturbance anxiety, apathy, and impulsive behavioral disorders. There was a significant association between the quality of life and severity of anxiety, depression, apathy, UPDRS III assessment, Hoehn and Yahr scale stage, disease duration, and levodopa equivalent dosage.
Keywords
Parkinson's disease,
apathy,
anxiety,
depression,
impulsive behavioral disorders,
drowsiness,
constipation
Supporting agencies: The study was performed with the support of Council on grants of the President of the Russian Federation (Grant № МК-813.2019.7, "Clinical and epidemiological features of neurodegenerative diseases of the Tomsk region")
About the Authors
M. A. Nikitina
Siberian State Medical University
Russian Federation
Russian Federation
Nikitina Maria A. – MD, PhD, Associate Professor, Department of Neurology and Neurosurgery
Tomsk, 8-913-865-4918
N. G. Zhukova
Siberian State Medical University
Russian Federation
Russian Federation
Zhukova Natalya G. –MD, PhD, Professor, Department of Neurology and Neurosurgery
Tomsk, 8-913-824-6202
E. Yu. Bragina
Research Institute of Medical Genetics, Tomsk NRMC
Russian Federation
Russian Federation
Bragina Elena Yu. - PhD, Senior Researcher, Laboratory of Population Genetics
Tomsk, 8-913-823-4122
V. M. Alifirova
Siberian State Medical University
Russian Federation
Russian Federation
Alifirova Valentina M., MD, PhD, Professor, Head of the Department of Neurology and Neurosurgery
Tomsk, 8-913-850-0240
I. A. Zhukova
Siberian State Medical University
Russian Federation
Russian Federation
Zhukova Irina A. – MD, PhD, Associate Professor, Department of Neurology and Neurosurgery
Tomsk, 8-913-800-6296
D. E. Gomboeva
Tomsk National Research Medical Center, Tomsk NRMC
Russian Federation
Russian Federation
Gomboeva Densema E. – PhD student of the Laboratory of Population Genetics, Research Institute of Medical Genetics
Tomsk, 8-923-409-6698
N. G. Brazovskaya
Siberian State Medical University
Russian Federation
Russian Federation
Brazovskaya Natalia G. – PhD, Associate Professor, Department of Medical and Biological Cybernetics
Tomsk, 8-913-884-7333
O. P. Izhboldina
Siberian State Medical University
Russian Federation
Russian Federation
Izhboldina Olga P. - MD, PhD, Neurologist
Tomsk, 8-913-853-6047
I. Zh. Zhalsanova
Tomsk National Research Medical Center, Tomsk NRMC
Russian Federation
Russian Federation
Zhalsanova Irina Zh. – PhD student of the Laboratory of Population Genetics, Research Institute of Medical Genetics
Tomsk, 8-923-409-6698
References
1. Methods for evaluating of olfactory function in patients with Parkinson’s disease / I.A. Zhukova, N.G. Zhukova, O.P. Izhboldina [et al.] // S.S. Korsakov Journal of Neurology and Psychiatry. – 2015. – №115 (2). – P. 47-52; doi: 10.17116/jnevro20151156244-49
2. Correlation between emotional-affective disorders and gut microbiota composition in patients with Parkinson’s disease / V.M. Alifirova, N.G. Zhukova, I.A. Zhukova [et al.] // Annals of the Russian academy of medical sciences. – 2016. – №71(6). (In Russ.) https://doi.org/10.15690/vramn734; doi: 10.15690/vramn734
3. Differential diagnosis of Multiple system atrophy and essential tremor with Parkinson’s disease (clinical cases) / A.A. Tappakhov, T.Ya. Nikolaeva, A.D. Alexeeva [et al.] // Yakut medical journal.– 2016. – № 2 (54). – P 90-93; https://elibrary.ru/item.asp?id=26196099
4. Clinical description of affective disorders and efficiency of antidepressant therapy / E.V. Lebedeva, E.D. Schastnyy, G.G. Simutkin [et al.] // Bulletin of Siberian Medicine. – 2018 –№17(4) – С. 85-93. doi: 10.20538/1682-0363-2018-4-85-93; https://doi.org/10.20538/1682-0363-2018-4-85-93
5. Levin O.S. Parkinson's disease: modern approaches to diagnosis and treatment / O.S. Levin, D.V. Artemyev, E.V. Bril, T.K. Kulua // PM. – 2017. Vol. 1, №1 (102), 2017, P.45-51. URL: https://cyberleninka.ru/article/n/bolezn-parkinsona-sovremennye-podhody-k-diagnostike-i-lecheniyu
6. Epidemiology of Parkinson’s disease in the RS(Ya) / T.E. Popova, A.A. Tappakhov, T. Ya. Nikolaeva, [et al.] // Yakut medical journal. – 2017. – №3 (59). – С. 98-101. https://elibrary.ru/item.asp?id=29899690
7. Fenelon G. Epidemiology of psychosis in Parkinson's disease / G. Fenelon, G. Alves // Journal of the Neurological Sciences. – 289 (1-2). – 2010. – P.12-17; doi: 10.1016/j.jns.2009.08.014 https://www.ncbi.nlm.nih.gov/pubmed/19740486
8. Hauser R. Determination of minimal clinically important change in early and advanced Parkinson's disease / R. Hauser and P. Auinger // Mov. Disord. – 2011. – 26(5). – pp.813-818; doi: 10.1002/mds.23638; https://doi.org/10.1002/mds.23638
9. Lang A. A critical appraisal of the premotor symptoms of Parkinson's disease: potential usefulness in early diagnosis and design of neuroprotective trials / A.A. Lang // Mov. Disord. 2011: 26(5). – P. 775-783; doi: 10.1002/mds.23609, https://doi.org/10.1002/mds.23609
10. Martínez-Martín P. Parkinson disease: depression and anxiety in Parkinson disease / P. Martínez-Martín, J. Damián // Nature Reviews Neurology. – 2010. – 6(5). – P. 243-245; doi: 10.1038/nrneurol.2010.49
11. Merello M. Correlation between the movement disorders society unified Parkinson’s disease rating scale (MDS-UPDRS) and the unified Parkinson’s disease rating scale (UPDRS) during l-dopa acute challenge / M. Merello, E. Gerschcovich, D. Ballesteros, D. Cerquetti // Parkinsonism & Related Disorders. – 2011. – 17(9). – pp.705-707. doi: 10.1016/j.parkreldis.2011.07.002
12. Nonmotor symptoms in Parkinson’s disease in 2012: relevant clinical aspects / A. Bonnet, M. Jutras, V. Czernecki [et al.] // Parkinson's Disease. – 2012. – pp.1-15; doi: 10.1155/2012/198316, http://dx.doi.org/10.1155/2012/198316
13. Parkinson disease: neuropsychiatric and cognitive profiling of patients with early, untreated Parkinson disease. // Nature Reviews Neurology. – 2015. 11(4). – P.186-186; doi:10.1038/nrneurol.2015.47, https://doi.org/10.1038/nrneurol.2015.47
14. Prevalence of smell loss in Parkinson's disease: A multicenter study / A. Haehner, S. Boesveldt, H. Berendse [et al.] // Parkinsonism & Related Disorders. – 2009. – 15(7). – P.490-494; doi: 10.1016/j.parkreldis.2008.12.005, https://doi.org/10.1016/j.parkreldis.2008.12.005
15. Schapira A. The measurement and importance of non-motor symptoms in Parkinson disease / A. Schapira // Eur J Neurol. – 2014. – 22(1). – P. 2-3. doi: 10.1111/ene.12523, https://doi.org/10.1111/ene.12523
16. Tan L.C.S. Mood disorders in Parkinson's disease / L.C.S. Tan // Parkinsonism Relat Disord. –2012. – 18. – 1: S74–S76; doi:http:10.1016/S1353-8020(11)70024-4, https://doi.org/10.1002/9780470669600.ch76
Review
For citations:
Nikitina M.A., Zhukova N.G., Bragina E.Yu., Alifirova V.M., Zhukova I.A., Gomboeva D.E., Brazovskaya N.G., Izhboldina O.P., Zhalsanova I.Zh. The heterogeneity of non-motor symptoms in patients with Parkinson’s disease in Tomsk region. Yakut Medical Journal. 2019;(3):70-74. https://doi.org/10.25789/YMJ.2019.67.20
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