The relationship of the content of blood transport proteins with the state of the immune system in practically healthy inhabitants of the Svalbard archipelago during the polar day
https://doi.org/10.25789/YMJ.2023.84.25
Abstract
The article presents data on the content of transport proteins of the blood system in relation to the state of the immune system in people living in extremely unfavorable conditions of the Svalbard archipelago. It has been established that the inhabitants of Spitsbergen have an activation of cell migration into tissues in case of insufficient oxygenation of tissues. A decrease in the level of lymphocytes in the circulation causes a violation of the regulation of immune reactions with the accumulation in the blood of extracellular forms of receptors, circulating immune complexes. People living in Svalbard have an increased need for transport components of the blood system: haptoglobin, transferrin and IgM.
Keywords
neutropenia,
lymphopenia,
free forms of cell receptors,
immune complexes,
haptoglobin,
transferrin,
immunoglobulins,
Svalbard archipelago
Supporting agencies: A fragment of the work on the study of the features of the immune status of the inhabitants of the Svalbard archipelago was supported by the grant of the Russian Academy of Sciences No. 22-25- 20135 "Identification of immunological criteria for the risk of vascular catastrophes in people working in the Arctic" (Doctor of Medical Sciences, Professor L.K. Dobrodeeva).
About the Authors
K. O. Pashinskaya
N. Laverov Federal Center for Integrated Arctic Research
of the Ural Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Pashinskaya Ksenia Olegovna – junior researcher at the laboratory regulatory mechanisms of immunity of the Institute of physiology of natural adaptations
Work phone: (8182) 21-04-58
A. V. Samodova
N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Samodova Anna Vasilievna – PhD (Biology), Leading Researcher, Head of laboratory regulatory mechanisms of immunity of the Institute of physiology of natural adaptations
Work phone: (8182) 21-04-58.
L. K. Dobrodeeva
N. Laverov Federal Center for Integrated Arctic Research
of the Ural Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Dobrodeeva Liliya Konstantinovna – MD, Prof., honored worker of science, Director, Chief Researcher of laboratory regulatory mechanisms of immunity, director of the Institute of physiology of natural adaptations
Work phone: (8182) 65-29-92
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Review
For citations:
Pashinskaya K.O., Samodova A.V., Dobrodeeva L.K. The relationship of the content of blood transport proteins with the state of the immune system in practically healthy inhabitants of the Svalbard archipelago during the polar day. Yakut Medical Journal. 2023;(4):105-109. https://doi.org/10.25789/YMJ.2023.84.25
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