Дефицит витамина D у детей до пяти лет с эпилепсией во Вьетнаме

Дефицит витамина D может усугубляться у детей с эпилепсией вследствие ограниченной инсоляции и длительного приёма противоэпилептических препаратов. Цель – определить распространённость дефицита витамина D и ассоциированные факторы риска у детей младше пяти лет с эпилепсией во Вьетнаме. Проведено поперечное исследование на базе Вьетнамской национальной детской больницы (Ханой, июль 2023 – июнь 2024); включён 221 ребёнок, получавший терапию не менее 3 месяцев; уровень 25(OH)D определяли методом электрохемилюминесцентного иммуноанализа. Дефицит (<50 нмоль/л) выявлен у 19,4% пациентов. Связи с возрастом, полом, местом проживания и продолжительностью инсоляции не установлено (p > 0,05), тогда как отсутствие профилактической суплементации повышало риск дефицита (OR=6,79; 95% ДИ 2,56-18,1; p < 0,001). Результаты обосновывают регулярный скрининг и профилактическую суплементацию витамина D у детей с эпилепсией.

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