Популяционные особенности распределения частот аллелей генов стресс-реактивности AVPR1A, NR3C1, FKBP5 в якутской популяции

Впервые проведено исследование генетических вариантов rs3803107 гена AVPR1A, rs41423247 гена NR3C1 и rs3800373 гена FKBP5, влияющих на функционирование гипоталамо-гипофизарно-надпочечниковой системы, в якутской популяции. Оценка частот генотипов и аллелей исследуемых локусов в выборке из 120 мужчин и 212 женщин якутской национальности позволила выявить значимые различия с большинством исследованных ранее популяций Западной Европы, Южной и Восточной Азии, Волго-Уральского региона. Выявленная специфика распределения частот аллелей изученных локусов у якутов свидетельствует об особенностях генетического профиля популяции.

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