Indicators of the antioxidant system of red blood cells in lung cancer patients
Abstract
This paper presents the results of a study of glutathione in the patients with lung cancer. We obtained results showing the intensification of free radical oxidation of lipids and depletion of glutathione system in the organism of patients.
About the Authors
V. M. NikolaevRussian Federation
Nikolaev Vyacheslav Mikhailovich, PhD, Senior Scientist, Laboratory of immunological mechanisms of adaptation
Yakutsk
F. G. Ivanova
Russian Federation
Ivanova Feodosiia Gavril’evna, PhD, Head of the Department of chemotherapy
Yakutsk
A. G. Egorova
Russian Federation
Egorova Aytalina Grigor’evna, Ph.D, Senior Scientist of the laboratory of medical and social research and study of the functional reserve of human
Yakutsk
L. V. Grigorieva
Russian Federation
Grigorieva Lena Valer’evna, PhD, Head of the Laboratory of immunological mechanisms of adaptation
Yakutsk
N. K. Chirikova
Russian Federation
Chirikova Nadezhda Konstantinovna, PhD (pharmacy), Associate Professor of Department of Biochemistry and Biotechnology, BGF
Yakutsk
S. S. Nakhodkin
Russian Federation
Nakhodkin Sergey Sergeevich, a graduate student, Department of Biochemistry and Biotechnology, BGF
Yakutsk
T. I. Ksenofontova
Russian Federation
Ksenofontova Tuyara Ivanovna, a graduate student, Department of Biochemistry and Biotechnology, BGF
Yakutsk
N. A. Barashkov
Russian Federation
Barashkov Nikolai Alexeevich, PhD, Researcher, Laboratory of Molecular Biology
Yakutsk
T. S. Markova
Russian Federation
Markova Tuyana Sergeevna, Ph.D, Senior Scientist, Laboratory of immunological mechanisms of adaptation
Yakutsk
S. D. Efremova
Russian Federation
Efremova Svetlana Dmitr’evna, research assistant, laboratory of immunological mechanisms of adaptation
Yakutsk
F. V. Vinokurova
Russian Federation
Vinokurova Fekla Vasil’evna, junior Scientist, laboratory of immunological mechanisms of adaptation
Yakutsk
S. A. Fedorova
Russian Federation
Fedorova Sardana Arkadyevna, D. of Biology, head of the Laboratory of Molecular Genetics
Yakutsk
P. M. Ivanov
Russian Federation
Ivanov Pyotr Mikhailovich, MD, prof.;
Head of the Laboratory of precancerogenesis and malignant tumors
Yakutsk
References
1. The antioxidant activity and lipid peroxidation in patients with endometrial cancer / E.A. Vinokurova, N.N. Frank, N.V. Boyarskykh, N.N. Yaskevich // Sib . Oncol. Journal. - 2007. - App. Number 1. - P. 125 - 126.
2. Dubinina E.E. The role of reactive oxygen species as signal molecules in the metabolism of tissues in a state of oxidative stress / E.E. Dubinina / / Issues of med. chemistry. - 2001. - №6. - P. 558 - 561.
3. Zenkov N.K. Oxidative stress: Biochemical and pathophysiological aspects / N.K. Zenkov, V.Z. Lankin, E.B. Menshchikova. - M., 2001. - 343 p.
4. Kaynova E.A. A comparative analysis of survival and lymphoid epithelial relationship with variants of squamous cell lung cancer / E.A. Kaynova // Collection of scientific works of students and young scientists YaGMA. - Yaroslavl: YaGMA, 2007. - P.19 -20.
5. Panchenko K.I. Survival of patients with squamous cell carcinoma of lung of different histological structure / K.I. Panchenko, Y. A. Kudachkov, I.S. Andeev // 30 years of clinical hospital № 9 of Yaroslavl: Proc. scientific and practical conf. - Yaroslavl, 1998 . - P.121-123.
6. Lipid peroxidation in the tissue of endometrial cancer: association with hormone-sensitive tumors and hormonal carcinogenesis / L.M. Bernstein, A.V. Vakulenko, A.S. Wisniewskii, E. V. Tsyrlina / / Issues of oncology. - 1996. - № 3. - p. 37 - 39.
7. The current state and problems of specialized cancer care to the population of Yakutia / Ivanov P.M., Tomskiy M.I., Kipriyanova N.S. [et. al] / / Yakut Medical Journal . - 2011. - № 1. Pp. 5 - 9.8.
8. Laboratory Methods Directory / L.A. Danilova. - St. Petersburg : Piter, 2003. - P. 398 - 399.
9. Griffith O.W. Determination of Glutathione and Glutathione Disulfide Using Glutathione Reductase and 2-Vinylpyridine / O.W. Griffith // Anal. Biochem. 1980. – V.106. P. 207 - 212.
10. Habig W.H. Glutathione-S-transferases: The first enzymatic step in mercapturic acid formation / W. H. Habig, M. J. Pabst, W. B. Jakoby // J. Biol. Chem. - 1974. V.249. P. 7130 – 7139.
11. Lack of PTEN expression in endometrial intraepithelial neoplasia is correlated with cancer progression / J.P. Baak, B. Van Diermen, А. Steinbakk et al. //Hum. Pathol. – 2005. – V. 36, №5. P. 555 - 561.
12. A population-based study of glutathione Stransferase M1, T1 and P1 genotypes and risk for lung cancer / V. Nazar-Stewart, T.L. Vaughan, P. Stapleton et. al., // Lung Cancer. – 2003. - V.40. P.247 - 258.
13. Obeidat B. The diagnosis of endometrial hyperplasia on curettage: how reliable is it? /B. Obeidat, A. Mohtaseb, I. Matalka //Arch. Gynecol. Obstet. – 2009. – V.279, N4. P. 489 - 492.
14. Pennant S. Endometrial atypical hyperplasia and subsequent diagnosis of endometrial cancer: a retrospective audit and literature review / S. Pennant, S. Manek, S. Kehoe // J. Obstet. Gynecol. – 2008. – V.28, N6. P. 632-633.
15. Combined effect of polymorphic GST genes on individual susceptibility to lung cancer / Saarikoski S.T., Voho A., Reinikainen M., et al., // Int J Cancer. - 1998. - V.77. P.516 – 521.
16. Isoenzyme(s) of glutathione transferase (class A) as a marker for the susceptibility to lung cancer: a follow up study / Seidegard J., Pero R.W., Markowitz M.M. et al. // Carcinogenesis. – 1990. – V.11. P.33 – 36
Review
For citations:
Nikolaev V.M., Ivanova F.G., Egorova A.G., Grigorieva L.V., Chirikova N.K., Nakhodkin S.S., Ksenofontova T.I., Barashkov N.A., Markova T.S., Efremova S.D., Vinokurova F.V., Fedorova S.A., Ivanov P.M. Indicators of the antioxidant system of red blood cells in lung cancer patients. Yakut Medical Journal. 2013;(4):7-9.
JATS XML










