The level of immunoglobulins at acute respiratory viral infection in frequently ill children – carriers of gene polymorphism (Asp299gly) TOLL-4 and (ser249pro) TOLL-6 receptors
Abstract
In the article the role of polymorphisms of genes Toll-4 and Toll-6 receptor in the development of low antiviral defense of sickly children is examined. It is shown that in the blood of children the content of IgM, IgG and its subclasses increases, and the concentration of IgA is reduced. At the genetic mutations in (Asp 299 Gly) Toll-4 and (Ser 249 Pro) Toll-6 receptors synthesis of explored immunoglobulins is reduced, that is regarded as one of the reasons for the low antiviral defense of children with genetic defects in the immune system signaling receptors.
About the Authors
L. P. Malezhik
State educational establishment of higher professional education Chita state medical Academy
Russian Federation
Russian Federation
Malezhik Lidia Pavlovna – MD, prof.
Chita
M. S. Malezhik
State educational establishment of higher professional education Chita state medical Academy
Russian Federation
Russian Federation
Malezhik Margarita Sergeevna - MD, PhD, Department of Assistant
Chita
D. T. Nimaeva
State educational establishment of higher professional education Chita state medical Academy
Russian Federation
Russian Federation
Nimaeva Dulma Tsybenovna - MD, PhD
Chita
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Review
For citations:
Malezhik L.P., Malezhik M.S., Nimaeva D.T. The level of immunoglobulins at acute respiratory viral infection in frequently ill children – carriers of gene polymorphism (Asp299gly) TOLL-4 and (ser249pro) TOLL-6 receptors. Yakut Medical Journal. 2016;(3):76-79.
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