Algorithm optimization of pathoanatomical diagnosis of prostate cancer with application of an immunohistochemical method
Abstract
Pathological differential diagnosis of primary high-grade prostatic adenocarcinoma (Gleason sum 6) and benign prostatic hyperplasia in transrectal prostate biopsy has been conducted with using an optimized panel of antibodies to cytokeratin 34βE12, cytokeratins 5 and 6, protein P63, AMACR, PSA and/or PSAP, which in 100% of cases conduced to establish the appropriate diagnosis. This immunohistochemical analysis can be recommended for carrying out life-time pathotogical diagnostics of prostate cancer besides the traditional research of a material from 12-24 points of biopsy with coloring of micropreparations with hematoxylin-eozin and determining a degree grade by Gleeson’s scale.
About the Authors
A. V. Smirnov
ФУВ «Волгоградский государственный медицинский университет»
Russian Federation
Russian Federation
G. L. Snigur
ФУВ «Волгоградский государственный медицинский университет»
Russian Federation
Russian Federation
D. V. Perlin
ФУВ «Волгоградский государственный медицинский университет»
Russian Federation
Russian Federation
D. U. Gurov
ФУВ «Волгоградский государственный медицинский университет»
Russian Federation
Russian Federation
References
1. Kazantseva M.V. Effectiveness of Degarelix at the common incidence rate of prostate cancer after progression on MAB standard scheme: analysis of a clinical case of malignant tumors / M.V. Kazantseva, E.A. Strygina. – 2014. – № 1 (8). – P. 47-51.
2. The method of differential morphological diagnosis of prostate pathology based on immunohistochemical detection of biomolecular markers of basal cells and oncogenesis / V.A. Zakharov, T.A. Letkovskaya, A.S. Portyanko [et al.] – Minsk, 2010.– P. 9.
3. Oncological diseases of the genitourinary system / E.I. Kopyltsov, A.I. Novikov, V.K. Kosenok [et al.]. – Omsk: Publishing House of the Center for Defense and IT Omsk State. Med. Academy, 2008. – P. 197.
4. Prostate gland tumors. Morphological diagnosis and genetics: Manual / Y.Y. Andreeva, L.V. Moskvin, L.E. Zavalishina [et al.] / Ed. Y.Y. Andreeva, G.A. Frank. – M., 2011. – P. 70.
5. Pisarev V.B. Prostate cancer: a study of biopsy material / V.B. Pisarev, B.V. Golub, G.L. Snigur / Guidelines. – Volgograd, 2007.– P. 53.
6. EAU guidelines on prostate cancer. Part 1: Screening, diagnosis, and local treatment with curative intent-update 2013 / A. Heidenreich, P.J. Bastian, J. Bellmunt [et al.] // Eur. Urol.– 2014.– V. 65.– P.124–137.
7. Sano F. The Utility and Limitations of Contrast-Enhanced Ultrasound for the Diagnosis and Treatment of Prostate Cancer / F. Sano, H. Uemura // Sensors.– 2015.– V. 15.– P.4947-4957.
8. Tadrous P.J. Diagnostic criteria handbook in histopathology: a surgical pathology vade mecum / P.J. Tadrous /by John Wiley & Sons, Ltd.– 2007.– P. 454.
9. Using an AMACR (P504S)/34betaE12/p63 cocktail for the detection of small focal prostate carcinoma in needle biopsy specimens/ Z. Jiang, C. Li, A. Fischer [et al.] // Am J. Clin. Pathol. -2005. -Vol. 123, № 2. – P. 231-236.
10. Utility of alpha-methylacyl coenzyme A racemase (p504s antibody) as a diagnostic immunohistochemical marker for cancer / A. Nassar, M.B. Amin, D.G. Sexton [et al.] // Appl Immunohistochem Mol Morphol. -2005. – Vol. 13, № 3. – P. 252-255.
Review
For citations:
Smirnov A.V., Snigur G.L., Perlin D.V., Gurov D.U. Algorithm optimization of pathoanatomical diagnosis of prostate cancer with application of an immunohistochemical method. Yakut Medical Journal. 2015;(2):41-43.
Views:
62
Email this article 