Correlation of blood serum transport protein content of immunoglobulins of m, g, a and e class with the level of immune response in inhabitants of the Arctic zone of the Russian Federation

The paper presents the results of studying of the relationship of serum immunoglobulins (Ig) content of classes M, G, A and E with the level of immune response in residents of the Arctic zone of the Russian Federation. It was found that the average concentration of IgM, IgA and IgE in the peripheral venous blood of the Arctic residents was higher by 1.5-2 times, the registration frequency of elevated levels was higher by 2.4-8.6 times than of the people living in more favorable climatic conditions. Activation of autosensitization processes in Arctic residents is accompanied by a high frequency of recording of increased concentrations of autoantibodies to leukocytes, erythrocytes, ds-DNA, RNP, cardiolipin, oLDL at 10.41-57.14%. In the conditions of the Arctic a significant excessthe concentrations of CIC with IgM and IgA than the complexes with IgG, which indirectly confirms the activation of preventive inflammation responses and the more significant binding ability of secretory antibodies. The increase concentrations of IgM and IgA of the Arctic residents are associated with a decrease in cell-mediated cytotoxicity and with the increase in the level of IFN-γ, sCD71, which increases the efficiency clearance of waste product in hypoxic conditions.

1. Vinogradova V.V. Nature and Bioclimatic Life Conditions of the Population of the Murmansk Oblast / V.V. Vinogradova // Regional Research of Russia. – 2015. ‒ No. 6. – P. 90-99.

2. Gushchin I.S. Immunoglobulin E (IgE) physiology / I.S. Gushchin // Russian Journal of Physiology. – 2000. – Vol. 86, No. 3. – P. 268-279.

3. Dobrodeeva L.K. Interrelations in the immune system // L.K. Dobrodeeva, A.V. Samodova, O.E. Karyakina. ‒ Ekaterinburg: publishing house of the Ural branch of the Russian Academy of Sciences, 2014. ‒ 200 p.

4. Dobrodeeva L.K. Maintenance immunoglobulin E in whey of blood in norm and pathology at the people living in the European territory of Russia / L.K. Dobrodeeva // Human Ecology. ‒ 2010. No. 5. ‒ P. 3-10. (In Russ.)

5. Евсеева И.В. Показатели иммунного статуса в двух коренных этнических группах Севера / И.В. Евсеева // Экология человека. ‒ 2010. ‒ № 10. ‒ С. 37-41. Evseeva I.V. Indicator of two radical ethnic group immune status in the far north / I.V. Evseeva // Human Ecology. – 2010. ‒ No. 10. ‒ P. 37-41.

6. Klimovich V.B. Immunoglobulin A (IgA) and its receptors / V.B. Klimovich, M.P. Samoilovich // Med. Immunol. ‒ 2006. ‒ Vol. 8, No. 4. ‒ P. 483- 500.

7. Kravtsov A.L. Neutrophil secretory degranulation as a trigger of inflammation and regulator of immune response: role of serine leukocyte proteases and protease-activated receptors / A.L. Kratsov, T.P. Shmelkova // Epidemiology and Vaccinal Prevention. ‒ 2011. ‒ No. 56. ‒ P. 79-87.

8. Krasavtseva E.A. State of water bodies in the area of influence of mining and processing enterprises (case study of Lovozersky mining and processing plant) / E.A. Krasavtseva, S.S. Sandimirov // Water and Ecology. ‒ 2021. ‒ No. 2(86). ‒ P. 4-12. DOI: 10.23968/2305-3488.2021.26.2.3-13

9. Myagkova M.A. Nature antibodies and their physiological function / M.A. Myagkova, V.S. Morozova // Immunology, Allergology, Infectology. ‒ 2014. ‒ No. 3. ‒ P. 75-81. DOI: 10.14427/jipai.2014.3.75.

10. Nikiforova N.A. Feeding habits of the northerners (literature review) / N.A. Nikiforova, T.A. Karapetyan, N.V. Dorshakova // Human Ecology. ‒ 2018. ‒ No. 11. ‒ P. 20-22.

11. Antigen membrane soluble forms of immune system cells / V.V. Novikov, A. Yu. Baryshnikov, A.V. Karaulov // Immunology. ‒ 2007. ‒ No. 4. ‒ P. 249-254.

12. Sedykh S.E. Polyreactivity of natural antibodies: exchange by HL-fragments / S.E. Sedykh, V.N. Buneva, G.A. Nevinsky // Biochemistry. ‒ 2013. ‒ Vol. 78, No. 12. ‒ P. 1651-1669.

13. Chuchalin A.G. Diseases associated with immunoglobulin G / A.G. Chuchalin // Therapeutic archive ‒ 2018. ‒ No. 3. ‒ P. 4-9.

14. Assessment of physical and chemical properties, health risk of trace metals and quality indices of surface waters of the rivers and lakes of the Kola Peninsula (Murmansk Region, North–West Russia) / E. Yakovlev, А. Druzhinina, S. Druzhinin et al. // Environmental Geochemistry and Health. ‒ 2021. DOI: 10.1007/s10653-021-01027-5

15. Ecosystem and human health assessment in relation to aquatic environment pollution by heavy metals: Case study of the Murmansk region, northwest of the Kola Peninsula Russia / T.I. Moiseenko, B.A. Morgunov, N.A. Gashkina [et al.] // Environmental Research Letters. ‒ 2018. ‒ Vol. 13, N. 6. DOI: 10.1088/1748-9326/aab5d2

16. Hypoxia-inducible factors in T lymphocyte differentiation and function / J.H. Tao, J. Barbi, F. Pan // AJP-Cell Physiol. ‒ 2015. ‒ Vol. 309, N. 9. ‒ P. 580-589. DOI: 10.1152/ajpcell.00204.2015.

17. Mestecky J. The human IgA system: a reassessment / J. Mestecky, M.W. Russell, S. Jackson, T.A. Brown // Clin. Immunol. Immunopathol. – 1996. – Vol. 40, N. 1. – P. 105–114.

18. Metzger H. Molecular versatility of antibodies / H. Metzger // Immunological Reviews. ‒ Vol. 185. ‒ P. 186-205. DOI: 10.1034/j.1600-065x.2002.18516.x.

19. Tomasi T.B. Structure and function of immunoglobulin A / T. B. Tomasi, H. M. Grey // Progress in Allergy. – 1972. – Vol. 16. – P. 81-213.