Polymorphism of genes of enzymes of the 2-nd phase of the xenobiotic detoxication in patients with malignant neoplasms of a gastroenteric tract
Abstract
The purpose of research. Studying (estimation) of a parity normal (+ / + and 0 / +) and zero (0/0) genotypes of glutation-Stransferase genes Т1 (GSTT1) in patients with malignant neoplasms of a gastroenteric tract.
Material and methods. In the present work 61 patient with malignant neoplasms of a stomach and intestines of the I - IV stages has been surveyed. Group of comparison was made from 30 patients with chronic diseases and good-quality changes in mucous of the gastroenteric tract and 100 healthy donors of a comparable sex and age. All patients have received the surgical treatment, the removed tissues were taken for histologic research which was spent in branch of pathological morphology of the Tomsk regional oncological clinic and in branch of pathological morphology MCCH-81 (Seversk).
The received results enable us to assume, that the lowered activity or absence of some enzymes of the second phase of the detoxication promotes longer preservation in an organism of intermediate products of xenobiotic biotransformation which at the initial stages can be rather toxic, show more expressed mutagen and cancerogenic activity in comparison with native xenobiotics [2, 7] and due to it becomes one of predisposing etiological factors of development of a cancer.
About the Authors
A. M. Nekrasova
ООО «СК АЛРОСА»;
СибГМУ
Russian Federation
Russian Federation
N. V. Sevostjanova
СибГМУ
Russian Federation
Russian Federation
I. A. Hlusov
СибГМУ
Russian Federation
Russian Federation
G. K. Zherlov
НИИ гастроэнтерологии СибГМУ
Russian Federation
Russian Federation
V. V. Novitskij
СибГМУ
Russian Federation
Russian Federation
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Review
For citations:
Nekrasova A.M., Sevostjanova N.V., Hlusov I.A., Zherlov G.K., Novitskij V.V. Polymorphism of genes of enzymes of the 2-nd phase of the xenobiotic detoxication in patients with malignant neoplasms of a gastroenteric tract. Yakut Medical Journal. 2007;(4):30-33. (In Russ.)
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