Role of genes inhibitors methylation of cyclin-dependent kinases in epigenetic inactivation of retinoblastomal way of regulation of a cellular cycle at a breast cancer
Abstract
Methylation STATus of RB1, p14ARF, and p15INK4B cell-cycle control genes was investigated in 40 cases of breast cancer by methylationspecific polymerase chain reaction. The frequency of cancer-related gene methylation was: p14ARF (72%), p15INK4B (12%) and RB1 (0%). It is suggested that epigenetic inactivation of Rb growth-control pathway in breast cancer can be mediated on the cycline-dependent kinase inhibitors level.
About the Authors
N. A. Skrjabin
НИИ медицинской генетики СО РАМН
Russian Federation
Russian Federation
I. N. Lebedev
НИИ медицинской генетики СО РАМН
Russian Federation
Russian Federation
E. N. Tolmacheva
НИИ медицинской генетики СО РАМН
Russian Federation
Russian Federation
N. V. Cherdyntseva
НИИ медицинской генетики СО РАМН;
НИИ онкологии СО РАМН
Russian Federation
Russian Federation
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Review
For citations:
Skrjabin N.A., Lebedev I.N., Tolmacheva E.N., Cherdyntseva N.V. Role of genes inhibitors methylation of cyclin-dependent kinases in epigenetic inactivation of retinoblastomal way of regulation of a cellular cycle at a breast cancer. Yakut Medical Journal. 2009;(2):89-91. (In Russ.)
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