ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2019.67.06ymj-993Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHГенетическое разнообразие в якутской популяции по локусам, ассоциированным с индексом массы тела и ожирениемGenetic diversity in Yakut population by loci associated with body mass index and obesityПоповичА. А.PopovichA. A.

Попович Анастасия Андреевна – к.б.н., м.н.с.

Popovich Anastasia Andreevna, Ph.D. Junior Researcher

anastasia.cherednichenko@medgenetics.ruТрифоноваЕ. А.TrifonovaE. A.

Трифонова Екатерина Александровна – к.м.н., н.с.

Trifonova Ekaterina Aleksandrovna, Ph.D. Scientific Researcher

ekaterina-trifonova@medgenetics.ruБочароваА. В.BocharovaA. V.

Бочарова Анна Владимировна – м.н.с.

Bocharova Anna Vladimirovna Junior Researcher

anna.bocharova@medgenetics.ruВагайцеваК. В.VagaitsevaK. V.

Вагайцева Ксения Валерьевна – к.б.н., н.с.

Vagaitseva Ksenia Valerievna, Ph.D. Scientific Researcher

kseniya.simonova@medgenetics.ruМаксимоваН. Р.MaximovaN. R.

Максимова Надежда Романовна – д.м.н., гл.н.с. Клиники МИ

Maximova Nadezhda Romanovna, Dr.Sc. Chief Researcher of the Clinic

nogan@yandex.ruСтепановВ. А.StepanovV. A.

Степанов Вадим Анатольевич – д.б.н., член-корр. РАН, руковод. лаб., врио директора

Stepanov Vadim Anatolevich, Dr.Sc., correspondent member RAS Head of the Laboratory of Evolutionary Genetics;

Acting Director

vadim.stepanov@medgenetics.ruНИИ медицинской генетики ФГБНУ «Томский национальный исследовательский медицинский центр Российской академии наук»РоссияResearch Institute of Medical Genetics, Federal State Budgetary Scientific Institution «Tomsk National Research Medical Center of the Russian Academy of Sciences»Russian FederationСВФУ им. М.К. АммосоваРоссияMedical Institute of Federal state Autonomous educational institution of higher professional education «North-Eastern Federal University named after M. K. Ammosov»Russian FederationНИИ медицинской генетики ФГБНУ «Томский национальный исследовательский медицинский центр Российской академии наук»РоссияResearch Institute of Medical Genetics, Federal State Budgetary Scientific Institution «Tomsk National Research Medical Center of the Russian Academy of Sciences»; Federal State Budgetary Scientific Institution «Tomsk National Research Medical Center of the Russian Academy of Sciences»Russian Federation201924082025032326Copyright © Попович А.А., Трифонова Е.А., Бочарова А.В., Вагайцева К.В., Максимова Н.Р., Степанов В.А., 20252025Попович А.А., Трифонова Е.А., Бочарова А.В., Вагайцева К.В., Максимова Н.Р., Степанов В.А.Popovich A.A., Trifonova E.A., Bocharova A.V., Vagaitseva K.V., Maximova N.R., Stepanov V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/993

В представленном исследовании в популяционной выборке якутов изучена изменчивость частот аллелей однонуклеотидных полиморфизмов, ассоциированных с ИМТ и ожирением, по данным GWAS. Полученные результаты сопоставлены с данными по 20 популяциям из международного проекта «1000 геномов». Выявлены генетические маркеры, вносящие наибольший вклад в генетическую дифференциацию популяций.

In the present study the variability of the GWAS-identified SNP allele frequencies associated with BMI and obesity was studied. The results of our study were compared with data on 20 populations from the international project “1000 Genomes”. Genetic markers that make the greatest contribution to the genetic differentiation of populations were identified.

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The authors declare that there are no conflicts of interest present.