ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2019.65.26ymj-860Research ArticleНАУЧНЫЕ ОБЗОРЫ И ЛЕКЦИИSCIENTIFIC REVIEWS AND LECTURESГенетические полиморфизмы системы гемостазаGenetic polymorphisms of the hemostasis systemСоловьеваЮ. А.SolovyovaYu. A.

Соловьева Юлия Алексеевна – аспирант

Solovyova Yulia Alekseevna, postgraduate student of “Normal and Pathological Physiology” department

27 Oyunskogo Street Yakutsk, 677000. Office number: +7 (914) 276-71- 20

md.pop@mail.ruБорисоваН. В.BorisovaN. V.

Борисова Наталья Владимировна – д.м.н., проф.

Borisova Natalya Vladimirovna, Doctor of Medical Sciences, Professor of “Normal and Pathological Physiology” department, Medical Institute

27 Oyunskogo Street Yakutsk, 677000. Office number: +7 (4112) 36-30- 46

borinat@yandex.ruСлепцоваС. С.SleptsovaS. S.

Слепцова Снежана Спиридоновна – д.м.н., зав. Кафедрой

Sleptsova Snezhana Spiridonovna, Doctor of Medical Sciences, Professor of “Infectious diseases, phthisiology and dermatovenereology” department, Medical Institute

27 Oyunskogo Street Yakutsk, 677000. Office number: +7 (4112) 43-22-25

sssleptsova@yandex.ruКуртановХ. А.KurtanovKh. A.

Куртанов Харитон Алексеевич – к.м.н., гл.н.с.-руковод. Отдела

Kurtanov Khariton Alekseyevich, Candidate of Medical Sciences, Chief researcher, Head of Department of Molecular Genetics

4 Sergelyakhskoye shosse Yakutsk, 677000. Office number: (4112) 32-19-81

hariton_kurtanov@mail.ruПавловаН. И.PavlovaN. I.

Павлова Надежда Ивановна – к.м.н., в.н.с.-руковод. лаб.

Pavlova Nadezhda Ivanovna, Candidate of Biological Sciences, leading researcher, Head of Hereditary Pathology laboratory

4 Sergelyakhskoye shosse Yakutsk, 677000. Office number: (4112) 32-19-81

solnishko_84@inbox.ruСоловьеваН. А.SolovyovaN. A.

Соловьева Наталья Алексеевна – к.м.н., в.н.с.

Solovyova Natalya Alekseevna, Candidate of Medical Sciences, leading researcher

4 Sergelyakhskoye shosse Yakutsk, 677000. Office number: (4112) 32-19-81

sonata608@yandex.ruМИ СВФУ им. М.К. АммосоваРоссияFederal State Autonomous Educational Institution of Higher Education “M. K. Ammosov North-Eastern Federal University”Russian FederationЯНЦ КМПРоссияYakut Science Centre of complex medical problemsRussian Federation201916082025018288Copyright © Соловьева Ю.А., Борисова Н.В., Слепцова С.С., Куртанов Х.А., Павлова Н.И., Соловьева Н.А., 20252025Соловьева Ю.А., Борисова Н.В., Слепцова С.С., Куртанов Х.А., Павлова Н.И., Соловьева Н.А.Solovyova Y.A., Borisova N.V., Sleptsova S.S., Kurtanov K.A., Pavlova N.I., Solovyova N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/860

В статье представлены основные гены системы гемостаза: FGB, FII, FV, FVII, FXIII, ITGA2, ITGB3, MTHFR, PAI-1, а также гены, имеющие отношение к системе гемостаза. Описана роль полиморфизмов данных генов в формировании патологических состояний, таких как тромбозы и тромбофилии, также рассмотрены полиморфизмы генов гемостаза, имеющие протективный эффект.

The main genes of hemostasis system are presented in article: FGB, FII, FV, FVII, FXIII, ITGA2, ITGB3, MTHFR, PAI-1 and also genes, concerning the system of hemostasis. The role of polymorphisms of these genes in formation of pathological states as thromboses and thrombophilia is described, also the polymorphisms of genes of hemostasis having protective effect are considered.

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The authors declare that there are no conflicts of interest present.