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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25789/YMJ.2025.90.19</article-id><article-id custom-type="elpub" pub-id-type="custom">ymj-781</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНАЯ ТЕМА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ACTUAL TOPIC</subject></subj-group></article-categories><title-group><article-title>Выявляемость злокачественных новообразований печени и внутрипеченочных желчных протоков в Республике Саха (Якутия)</article-title><trans-title-group xml:lang="en"><trans-title>Detection of malignant liver tumors and intrahepatic bile ducts in the Republic of Sakha (Yakutia)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2758-155X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никифоров</surname><given-names>П. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikiforov</surname><given-names>P. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Никифоров Петр Владимирович – директор ГБУ РС(Я) «ЯРМИАЦ», доцент Медицинского института СВФУ им. М.К. Аммосова</p></bio><email xlink:type="simple">niccifforof@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2592-5125</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Афанасьева</surname><given-names>Л. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Afanasyeva</surname><given-names>L. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Афанасьева Лена Николаевна – д.м.н., министр здравоохранения РС(Я), зав. кафедрой</p></bio><email xlink:type="simple">lenanik2007@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2746-0608</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Климова</surname><given-names>Т. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Klimova</surname><given-names>T. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Климова Татьяна Михайловна – к.м.н., доцент СВФУ им. М.К. Аммосова, с.н.с. ЯНЦ КМП.</p></bio><email xlink:type="simple">biomedykt@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1099-573X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Николаева</surname><given-names>Т. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikolaeva</surname><given-names>T. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Николаева Татьяна Ивановна – к.м.н., гл. врач ГБУ РС(Я) «Якутский республиканский онкологический диспансер», доцент Медицинского института СВФУ им. М.К. Аммосова</p></bio><email xlink:type="simple">nti_nika@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7661-1279</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванова</surname><given-names>Ф. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanova</surname><given-names>F. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иванова Феодосия Гаврильевна – к.м.н., руковод. отдела ГБУ РС(Я) «Якутский республиканский онкологический диспансер», ГВС по онкологии МЗ РС(Я), доцент Медицинского института ГБУ РС(Я) «Якутский республиканский онкологический диспансер»</p></bio><email xlink:type="simple">Feodossiaiv@inbox.ru</email><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГБУ РС(Я) «Якутский республиканский онкологический диспансер»; СВФУ им. М.К.  Аммосова, Медицинский институт</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>СВФУ им. М.К.  Аммосова, Медицинский институт</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-3"><institution>СВФУ им. М.К. Аммосова</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-4"><institution>ГБУ РС(Я) «Якутский республиканский онкологический диспансер»; СВФУ им. М.К. Аммосова</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-5"><institution>ГБУ РС(Я) «Якутский республиканский онкологический диспансер»</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>22</day><month>06</month><year>2025</year></pub-date><volume>0</volume><issue>2</issue><fpage>88</fpage><lpage>91</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Никифоров П.В., Афанасьева Л.Н., Климова Т.М., Николаева Т.И., Иванова Ф.Г., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Никифоров П.В., Афанасьева Л.Н., Климова Т.М., Николаева Т.И., Иванова Ф.Г.</copyright-holder><copyright-holder xml:lang="en">Nikiforov P.V., Afanasyeva L.N., Klimova T.M., Nikolaeva T.I., Ivanova F.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/781">https://ymj.elpub.ru/jour/article/view/781</self-uri><abstract><p>В статье представлено одномоментное ретроспективное исследование случаев злокачественных новообразований (ЗНО) печени и внутрипеченочных желчных протоков (C22) в Республике Саха (Якутия) за 2010–2019 гг. по данным статистических форм учета № 7, 35. За исследуемый период зарегистрированы существенно повышенные уровни заболеваемости и смертности от злокачественных новообразований печени и внутрипеченочных желчных протоков. При этом сохраняется низкая доля выявления изучаемой патологии на ранних стадиях, несмотря на усиление диагностических мероприятий в рамках профилактических осмотров и скрининговых программ.</p><p>В динамике за 2010–2019 гг. в РС(Я) отмечается рост показателя распространенности ЗНО печени и внутрипеченочных желчных протоков, но при этом число пациентов, находящихся под наблюдением 5 и более лет, имеет тенденцию к снижению. Полученные данные обосновывают необходимость совершенствования организационных подходов к ранней диагностике и лечению, оптимизации маршрутизации пациентов, а также исследования преканцерогенных факторов ЗНО печени у жителей РС(Я).</p></abstract><trans-abstract xml:lang="en"><p>The article presents a cross-sectional retrospective study of cases of malignant neoplasms (MN) of the liver and intrahepatic bile ducts (C22) in the Republic of Sakha (Yakutia) (RS (Y) for 2010–2019 based on statistical registration forms No. 7 and 35. During the study period, significantly increased levels of morbidity and mortality from malignant neoplasms of the liver and intrahepatic bile ducts were recorded. At the same time, the proportion of detection of the studied pathology at early stages remains low, despite the strengthening of diagnostic measures within the framework of preventive examinations and screening programs. In the dynamics for 2015–2019 in the RS (Y), the proportion of patients with MN of the liver and intrahepatic bile ducts who were under observation for 5 years decreased, while the contingent of patients with this pathology increased. The obtained data substantiate the need to improve organizational approaches to early diagnosis and treatment, optimize patient routing, and study pre-cancerous factors of liver cancer in residents of the Republic of Sakha (Yakutia).</p></trans-abstract><kwd-group xml:lang="ru"><kwd>злокачественные новообразования печени и внутрипеченочных желчных протоков</kwd><kwd>рак</kwd><kwd>выявляемость</kwd><kwd>Республика Саха (Якутия)</kwd></kwd-group><kwd-group xml:lang="en"><kwd>malignant neoplasms of the liver and intrahepatic bile ducts</kwd><kwd>cancer</kwd><kwd>detectability</kwd><kwd>Republic of Sakha (Yakutia)</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Биопсия сторожевого лимфатического узла при раке молочной железы с применением метода флуоресцентной визуализации красителя индоцианин зеленый / А.Д. Зикиряходжаев, Э.К. Сарибекян, Д.В. 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