ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2025.90.01ymj-763Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHКлинико-лабораторная оценка многорожавших женщин с железодефицитной анемиейClinical and laboratory evaluation of multiparous women with iron deficiency anemiaАлиеваП. И.AliyevaP. I.

Алиева Парвана Исмаил кызы – доктор философии по медицине.

Баку, ул. Самеда Вургуна, 163A, Насими

med_avtor@mail.ruАзербайджанский мед. университетAzerbaijan2025220620250259Copyright © Алиева П.И., 20252025Алиева П.И.Aliyeva P.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/763

В исследовании приняли участие 110 многорожавших беременных женщин в возрасте от 18 до 44 лет без анемии и с железодефицитной анемией. В связи с повышенной потребностью в витаминах и минеральных веществах во время беременности у многорожавших женщин с железодефицитной анемией, не получавших лечения (основная группа), произошли значимые изменения. Так, в группе сравнения уровень витамина D в III триместре составил 30,1±1,6, Me=32,7( 28,1–33,4), тогда как в основной группе – 14,2±0,4, Me=13,5(12,9–15,6) (pH<0,001).

У женщин с железодефицитной анемией выявлено достоверное изменение уровней микронутриентов, что наиболее выражено в последнем триместре беременности. Основная причина заключается в том, что витаминно-минеральный статус организма подвергается значительным изменениям ближе к концу беременности вследствие интенсивного развития плода.

The study involved 110 pregnant women aged 18 to 44 years. The control group (group I) consisted of 21 healthy women. Due to the increased need for vitamins and minerals during pregnancy, significant changes occurred in overweight women with iron deficiency anemia who did not receive treatment (the main group). So, in the comparison group, the vitamin D level in the third trimester was 30.1±1.6 Me=32.7(28.1–33.4), while in the main group it was 14.2±0.4 Me=13.5(12.9–15.6) (pH<0.001), compared with the control group p<0.001.

In women with iron deficiency anemia, compared with the control group, there was a significant change in micronutrient levels, which was most pronounced in the last trimester of pregnancy. The main reason is that the vitamin and mineral status undergoes significant changes towards the end of pregnancy due to the intensive development of the fetus.

многорожавшие женщиныжелезодефицитная анемиявитаминыминералыmultiparous womeniron deficiency anemiavitaminsmineralsReferencesБахарева И.В. Профилактика и лечение анемии беременных: результаты использования витаминно-минеральных комплексов (по данным Российской многоцентровой неинтервенционной программы «Прогностик») // Российский вестник акушера-гинеколога, 2017; 17 (3): 66-73. DOI: 10.17116/rosakush201717366-73.Bakhareva I.V. Prevention and treatment of anemia during pregnancy: Results of using vitamin-mineral complexes (according to the data of the Russian multicenter non-intervention program «PROGNOSTIC»). Russian Bulletin of Obstetrician-Gynecologist. 2017;17(3):66 73. DOI:10.17116/rosakush201717366-73.Бахарева И.В. Профилактика и лечение железодефицитных состояний у беременных // РМЖ. Мать и дитя, 2019; Т.2. №3:219-224 DOI:10.32364/2618-2-3-219-224.Bakhareva I.V. Prevention and treatment of iron deficiency in pregnancy. Russian Journal of Woman and Child Health. 2019;2(3):219–224.Кравцова Е.И., Куценко И.И., Боровиков И.О., Батмен С.К. Питание и нутритивная поддержка во время беременности // РМЖ. Мать и дитя. 2020;3(4):233-241. DOI: 10.32364/26188430-2020-3-4-233-241.Kravtsova E.I., Kutsenko I.I., Borovikov I.O., Batmen S.K. Nutrition and nutritional support during pregnancy. Russian Journal of Woman and Child Health. 2020;3(4):233–240. DOI: 10.32364/2618-8430-2020-3-4-233-241.Amberntsson A, Bärebring L, Winkvist A, Lissner L, Meltzer HM, Brantsæter AL, Papadopoulou E, Augustin H. Vitamin D intake and determinants of vitamin D status during pregnancy in The Norwegian Mother, Father and Child Cohort Study. Front Nutr. 2023 Jun 23;10:1111004. doi: 10.3389/fnut.2023.1111004.Amberntsson A, Bärebring L, Winkvist A, Lissner L, Meltzer HM, Brantsæter AL, Papadopoulou E, Augustin H. Vitamin D intake and determinants of vitamin D status during pregnancy in The Norwegian Mother, Father and Child Cohort Study. Front Nutr. 2023 Jun 23;10:1111004. doi: 10.3389/fnut.2023.1111004.Behere R.V., Deshmukh A.S., Otiv S. et al. Maternal Vitamin B12 Status During Pregnancy and Its Association With Outcomes of Pregnancy and Health of the Offspring: A Sistematic Review and Implications for Policy in India. Front Endocrinol (Lausanne), 2021; 12: 619176. doi: 10.3389/fendo.2021.619176.Behere R.V., Deshmukh A.S., Otiv S. et al. Maternal Vitamin B12 Status During Pregnancy and Its Association With Outcomes of Pregnancy and Health of the Offspring: A Sistematic Review and Implications for Policy in India. Front Endocrinol (Lausanne), 2021; 12: 619176. doi: 10.3389/fendo.2021.619176.Benson CS, Shah A, Frise MC, Frise CJ. Iron deficiency anaemia in pregnancy: A contemporary review. Obstet Med. 2021 Jun;14(2):67-76. doi: 10.1177/1753495X20932426Benson CS, Shah A, Frise MC, Frise CJ. Iron deficiency anaemia in pregnancy: A contemporary review. Obstet Med. 2021 Jun;14(2):67-76. doi: 10.1177/1753495X20932426Fanni D., Gerosa C., Nurchi V.M. et al. The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases. Biological Trace Element Research, 2021; 199: 3647-3657 .https//doi.org/10.1007/s12011-020-02513-0Fanni D., Gerosa C., Nurchi V.M. et al. The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases. Biological Trace Element Research, 2021; 199: 3647-3657 .https//doi.org/10.1007/s12011-020-02513-0Hansen R, Spangmose AL, Sommer VM, Holm C, Jørgensen FS, Krebs L, Pinborg A. Maternal first trimester iron status and its association with obstetric and perinatal outcomes. Arch Gynecol Obstet. 2022 Oct;306(4):1359-1371. doi: 10.1007/s00404-022-06401-xHansen R, Spangmose AL, Sommer VM, Holm C, Jørgensen FS, Krebs L, Pinborg A. Maternal first trimester iron status and its association with obstetric and perinatal outcomes. Arch Gynecol Obstet. 2022 Oct;306(4):1359-1371. doi: 10.1007/s00404-022-06401-xJones KS, Meadows SR, Schoenmakers I, Prentice A, Moore SE. Vitamin D Status Increases During Pregnancy and in Response to Vitamin D Supplementation in Rural Gambian Women. J Nutr. 2020;150(3):492-504. doi:10.1093/jn/nxz290Jones KS, Meadows SR, Schoenmakers I, Prentice A, Moore SE. Vitamin D Status Increases During Pregnancy and in Response to Vitamin D Supplementation in Rural Gambian Women. J Nutr. 2020;150(3):492-504. doi:10.1093/jn/nxz290Kavak Ç.E., Kavak S.B. The association between anemia prevalence, maternal age and parity in term pregnancies in our city. Perinatal Journal, 2017; 25(1): 6-10. DOI: 10.2399/prn.17.0251002Kavak Ç.E., Kavak S.B. The association between anemia prevalence, maternal age and parity in term pregnancies in our city. Perinatal Journal, 2017; 25(1): 6-10. DOI: 10.2399/prn.17.0251002Liu J., Song G., Zhao G. Et al. Effect of oral magnesiumsupplementation for relieving leg cramps during pregnancy:A meta-analysis of randomized controlled trials. Taiwanese Journal of Obstetrics, Ginecology, 2021; 60: 609-614. https://doi.org/10.1016/j.tjog.2021.05.006Liu J., Song G., Zhao G. Et al. Effect of oral magnesiumsupplementation for relieving leg cramps during pregnancy:A meta-analysis of randomized controlled trials. Taiwanese Journal of Obstetrics, Ginecology, 2021; 60: 609-614. https://doi.org/10.1016/j.tjog.2021.05.006Lutz B.H., da Silva dos Santos I., Domingues M.R. et al. Folic acid supplementation during pregnancyand postpartum depressive symptoms. Revista de Saúde Pública, 2023; 57: 76. https://doi.org/10.11606/1518-8787.2023057004962Lutz B.H., da Silva dos Santos I., Domingues M.R. et al. Folic acid supplementation during pregnancyand postpartum depressive symptoms. Revista de Saúde Pública, 2023; 57: 76. https://doi.org/10.11606/1518-8787.2023057004962Mao Y., Hu H., Chen D. et al. Investigating continauation of folic acid supplementation during pre-conceptional period: a community-based cross-sectional study. Reproductive Health, 2023; 20: 34. https//doi.org/10.1186/s12978-023-01564-5Mao Y., Hu H., Chen D. et al. Investigating continauation of folic acid supplementation during pre-conceptional period: a community-based cross-sectional study. Reproductive Health, 2023; 20: 34. https//doi.org/10.1186/s12978-023-01564-5Otunchieva A., Smanalieva J., Ploeger A. DietaryQuality of Woman of Reproductive Age in Low-Income Settings: A Cross-Sectional Stady in Kyrgyzstan. Nutrients, 2022; 14: 289.https://doi.org/10.3390/nul14020289Otunchieva A., Smanalieva J., Ploeger A. DietaryQuality of Woman of Reproductive Age in Low-Income Settings: A CrossSectional Stady in Kyrgyzstan. Nutrients, 2022; 14: 289.https://doi.org/10.3390/nul14020289Pavord S., Daru J., Prasannan N. et al. UK guidelines on the management of iron deficiency in pregnancy. British Journal of Haematology, 2020; 188(6): 819-830. doi: 10.1111/bjh.16221 2020,188,819-830Pavord S., Daru J., Prasannan N. et al. UK guidelines on the management of iron deficiency in pregnancy. British Journal of Haematology, 2020; 188(6): 819-830. doi: 10.1111/bjh.16221 2020,188,819-830Tsunoda K., Hamazaki K., Matsumura K. et al. Dietary Intake of Vitamin D during Pregnancy and the Risk of Postpartum Depressive Symptoms: the Japan evvironment and Children’s Study. Journal of Nutritional Science and Vitaminology, 2023; 69: 14-20 doi: 10.3177/jnsv.69.14.Tsunoda K., Hamazaki K., Matsumura K. et al. Dietary Intake of Vitamin D during Pregnancy and the Risk of Postpartum Depressive Symptoms: the Japan evvironment and Children’s Study. Journal of Nutritional Science and Vitaminology, 2023; 69: 14-20 doi: 10.3177/jnsv.69.14.Yalew M., Getachew S., Mohammed K. et.al. ndividual and contextual-level factors associated with iron-folic acid supplement inteke during pregnancy in Ethiopia:a multilevel analysis. BMC Pregnancy and Childbirth, 2023; 23: 260 https//doi.org/10.1186/s12884-023-05593-7Yalew M., Getachew S., Mohammed K. et.al. ndividual and contextual-level factors associated with iron-folic acid supplement inteke during pregnancy in Ethiopia:a multilevel analysis. BMC Pregnancy and Childbirth, 2023; 23: 260 https//doi.org/10.1186/s12884-023-05593-7

The authors declare that there are no conflicts of interest present.