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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25789/YMJ.2022.79.15</article-id><article-id custom-type="elpub" pub-id-type="custom">ymj-75</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНАЯ ТЕМА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ACTUAL TOPIC</subject></subj-group></article-categories><title-group><article-title>Особенности поражения желудочно-кишечного тракта у детей с мультисистемным воспалительным синдромом, ассоциированным с COVID-19</article-title><trans-title-group xml:lang="en"><trans-title>Features of gastrointestinal disorders in children with multisystem inflammatory syndrome associated with COVID-19</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аврусин</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Avrusin</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аврусин Илья Сергеевич – ст. лаб.</p></bio><bio xml:lang="en"><p>Avrusin Ilya S. – Senior Research Assistant of the Department of Hospital Pediatrics </p></bio><email xlink:type="simple">avrusin95@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белозеров</surname><given-names>К. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Belozerov</surname><given-names>K. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Белозеров Константин Евгеньевич – клинич. ординатор</p></bio><bio xml:lang="en"><p>Belozerov Konstantin E. – Clinical Resident of the Department of Hospital Pediatrics</p></bio><email xlink:type="simple">biancolago@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ефремова</surname><given-names>О. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Efremova</surname><given-names>O. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ефремова Олеся Станиславовна – врач кардиолог, Иркутская областная детская больница, ассистент кафедры Иркутской ГМА последипломн. образования</p></bio><bio xml:lang="en"><p>Efremova Olesya S. – Cardiologist, Irkutsk Regional Children's Hospital, Assistant of the Department of Pediatrics of Irkutsk State Medical Academy of Postgraduate Education</p></bio><email xlink:type="simple">shaguno@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Брегель</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bregel</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Брегель Людмила Владимировна – д.м.н., проф., зав. кафедрой Иркутской ГМА ПО, гл. детский кардиолог Иркутской области</p></bio><bio xml:lang="en"><p>Bregel Lyudmila V. – PhD, MD, Professor, Head of the Department of Pediatrics of Irkutsk State Medical Academy of Postgraduate Education, Chief Pediatric Cardiologist of Irkutsk Region</p></bio><email xlink:type="simple">loudmilabregel@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дондурей</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dondurey</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дондурей Елена Александровна – к.м.н., зав. отделением СПб ГБУЗ «Детская городская клинич. больница им. Н.Ф. Филатова», гл. внештат. детский инфекционист г. Санкт-Петербурга</p></bio><bio xml:lang="en"><p>Dondurey Elena A. – Candidate of Medical Sciences, Head of the Infectious boxed Department of the St. Petersburg State Medical Institution, N.F. Filatov Children's City Clinical Hospital, chief freelance pediatric infectious disease specialist of St. Petersburg</p></bio><email xlink:type="simple">dondureyelena@yandex.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вильниц</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vilnits</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вильниц Алла Ароновна – д.м.н., зав. отделом ФГБУ ДНКЦИБ ФМБА России. ПО МИ СВФУ им. М.К Аммосова</p></bio><bio xml:lang="en"><p>Vilnits Alla A. – PhD, MD, Head of the Research Department of Intensive Care of Emergency Conditions of the FSBI DNKCIB of the FMBA of Russia</p></bio><email xlink:type="simple">vilnitz@mail.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новгородова</surname><given-names>К. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Novgorodova</surname><given-names>K. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новгородова Кристина Олеговна – студентка 6 курса</p></bio><bio xml:lang="en"><p>Novgorodova Kristina O. – the student of the 6th year </p></bio><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бурцева</surname><given-names>Т. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Burtseva</surname><given-names>T. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бурцева Татьяна Егоровна – д.м.н., проф.; зав. лаб. </p></bio><bio xml:lang="en"><p>Burtseva Tatiana E. – PhD, MD, Professor of the Department of Pediatrics and Pediatric Surgery of MI NEFU, Head of the Laboratory YSC CMP</p></bio><email xlink:type="simple">bourtsevat@yandex.ru</email><xref ref-type="aff" rid="aff-7"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дмитриева</surname><given-names>Т. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Dmitrieva</surname><given-names>T. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дмитриева Татьяна Геннадьевна – д.м.н., проф.</p></bio><bio xml:lang="en"><p>Dmitrieva Tatiana G. – PhD, MD, Professor of the Department of Pediatrics and Pediatric Surgery </p></bio><email xlink:type="simple">dtg63@mail.ru</email><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корнишина</surname><given-names>Т. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Kornishina</surname><given-names>T. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Корнишина Татьяна Леонидовна – ассистент кафедры</p></bio><bio xml:lang="en"><p>Kornishina Tatiana L. – Assistant of the Department of Hospital Pediatrics </p></bio><email xlink:type="simple">tk.06@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Масалова</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Masalova</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Масалова Вера Васильевна - ассистент кафедры</p></bio><bio xml:lang="en"><p>Masalova Vera V. – assistant of the Department of Hospital Pediatrics </p></bio><email xlink:type="simple">masalova.vera@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Калашникова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kalashnikova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Калашникова Ольга Валерьевна – к.м.н.. доцент</p></bio><bio xml:lang="en"><p>Kalashnikova Olga V. – Candidate of Medical Sciences, Associate Professor of the Department of Hospital Pediatrics</p></bio><email xlink:type="simple">koira7@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аврусин</surname><given-names>С. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Avrusin</surname><given-names>S. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аврусин Сергей Львович – к.м.н., доцент</p></bio><bio xml:lang="en"><p>Avrusin Sergey L. – Candidate of Medical Sciences, Associate Professor of the Department of Hospital Pediatrics</p></bio><email xlink:type="simple">avrusin4@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Колобова</surname><given-names>О. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Kolobova</surname><given-names>O. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Колобова Оксана Леонидовна – к.м.н., доцент</p></bio><bio xml:lang="en"><p>Kolobova Oksana L. – Candidate of Medical Sciences, Associate Professor of the Department of Hospital Pediatrics </p></bio><email xlink:type="simple">aksjutakolobova@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Солодкова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Solodkova</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Солодкова Ирина Владимировна - к.м.н., доцент</p></bio><bio xml:lang="en"><p>Solodkova Irina V. – Candidate of Medical Sciences, Associate Professor of the Department of Hospital Pediatrics </p></bio><email xlink:type="simple">isolodkova@mail.ru</email><xref ref-type="aff" rid="aff-8"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Часнык</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Chasnyk</surname><given-names>V. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Часнык Вячеслав Григорьевич – д.м.н., проф., зав. кафедрой</p></bio><bio xml:lang="en"><p>Chasnyk Vyacheslav G. – PhD, MD, Professor, Head of the Department of Hospital Pediatrics </p></bio><email xlink:type="simple">chasnyk@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Костик</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kostik</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Костик Михаил Михайлович – д.м.н., проф., гл. внештат. детский специалист ревматолог </p></bio><bio xml:lang="en"><p>Kostik Mikhail M. – chief pediatric rheumatology specialist of the North-Western Federal District of Russia, PhD, MD, Professor of the Department of Hospital Pediatrics </p></bio><email xlink:type="simple">kost-mikhail@yandex.ru</email><xref ref-type="aff" rid="aff-9"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО СПбГПМУ МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint Petersburg State Pediatric Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Иркутская областная детская больница;&#13;
Иркутской ГМА последипломн. образования</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Irkutsk Regional Children's Hospital;&#13;
Irkutsk State Medical Academy of Postgraduate Education</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Иркутской ГМА ПО</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Irkutsk State Medical Academy of Postgraduate Education</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>СПб ГБУЗ «Детская городская клинич. больница им. Н.Ф. Филатова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>St. Petersburg State Medical Institution, N.F. Filatov Children's City Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ФГБУ ДНКЦИБ ФМБА России;&#13;
ПО МИ СВФУ им. М.К Аммосова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FSBI DNKCIB;&#13;
FMBA of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>ФГБОУ ВО СПбГПМУ МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>MI NEFU</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-7"><aff xml:lang="ru"><institution>ЯНЦ КМП</institution><country>Россия</country></aff><aff xml:lang="en"><institution>MI NEFU;&#13;
YSC CMP</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-8"><aff xml:lang="ru"><institution>ФГБОУ ВО СПбГПМУ МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-9"><aff xml:lang="ru"><institution>Северо-Западный федеральный округ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint Petersburg State Pediatric Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>03</day><month>02</month><year>2025</year></pub-date><volume>0</volume><issue>3</issue><fpage>57</fpage><lpage>61</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Аврусин И.С., Белозеров К.Е., Ефремова О.С., Брегель Л.В., Дондурей Е.А., Вильниц А.А., Новгородова К.О., Бурцева Т.Е., Дмитриева Т.Г., Корнишина Т.Л., Масалова В.В., Калашникова О.В., Аврусин С.Л., Колобова О.Л., Солодкова И.В., Часнык В.Г., Костик М.М., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Аврусин И.С., Белозеров К.Е., Ефремова О.С., Брегель Л.В., Дондурей Е.А., Вильниц А.А., Новгородова К.О., Бурцева Т.Е., Дмитриева Т.Г., Корнишина Т.Л., Масалова В.В., Калашникова О.В., Аврусин С.Л., Колобова О.Л., Солодкова И.В., Часнык В.Г., Костик М.М.</copyright-holder><copyright-holder xml:lang="en">Avrusin I.S., Belozerov K.E., Efremova O.S., Bregel L.V., Dondurey E.A., Vilnits A.A., Novgorodova K.O., Burtseva T.E., Dmitrieva T.G., Kornishina T.L., Masalova V.V., Kalashnikova O.V., Avrusin S.L., Kolobova O.L., Solodkova I.V., Chasnyk V.G., Kostik M.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/75">https://ymj.elpub.ru/jour/article/view/75</self-uri><abstract><p>Поражение ЖКТ является частью течения мультисистемного воспалительного синдрома у детей (МВС-Д), ассоциированного с новой короновирусной инфекцией COVID-19. По результатам ретроспективного исследования у детей с МВС-Д выявлено поражение ЖКТ, представленное такими признаками, как боль в животе, рвота, диарея и перитониальные симптомы. У этих детей отмечены значимые отличия в частоте встречаемости следующих признаков: гепатомегалия, спленомегалия, гипотония/шок, а также конъюнктивит и отёчность лица. Среди лабораторных отклонений более характерны гипоальбуминемия, но более высокий уровень СРБ и тропонина. В статье показано, что поражение ЖКТ является важным ранним предиктором тяжести МВС-Д.</p></abstract><trans-abstract xml:lang="en"><p>Resume. Gastrointestinal tract damage is a part of the course of multisystem inflammatory syndrome in children (MVS-D) associated with the new COVID-19 coronavirus infection. According to the results of a retrospective study, gastrointestinal tract damage was detected in 77% of patients with MVS-D and is represented by signs such as abdominal pain, vomiting, diarrhea and peritoneal symptoms. In children with gastrointestinal tract lesions, significant differences were noted in the frequency of occurrence of the following signs: hepatomegaly, splenomegaly, hypotension/shock, as well as conjunctivitis and facial swelling. Among laboratory abnormalities, hypoalbuminemia is more characteristic, but the level of CRP and troponin is higher. The article shows that gastrointestinal tract damage is an important early predictor of the severity of MVS-D.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>мультисистемный воспалительный синдром</kwd><kwd>поражение желудочно-кишечного тракта</kwd><kwd>гепатомегалия</kwd><kwd>спленомегалия</kwd><kwd>Россия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>multisystem inflammatory syndrome</kwd><kwd>gastrointestinal tract lesion</kwd><kwd>hepatomegaly</kwd><kwd>splenomegaly</kwd><kwd>Russia.</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Кадыркулов А.Ж. Мультисистемный воспалительный синдром, ассоциированный с COVID-19 и осложнённый деструктивным аппендицитом у ребёнка/ Кадыркулов А.Ж., Накипов Р.Н., Насыбуллин М.Н. // Medicus.- 2021.- № 1 (37).- С. 32-36.</mixed-citation><mixed-citation xml:lang="en">Kadyrkulov A.ZH. 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