ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2020.72.26ymj-737Research ArticleНАУЧНЫЕ ОБЗОРЫ И ЛЕКЦИИSCIENTIFIC REVIEWS AND LECTURESБиомаркеры эпилепсии: микроРНКBiomarkers of epilepsy: microRNAСапроноваМ. Р.SapronovaM. R.

Сапронова Маргарита Рафаильевна – к.м.н., доцент ИПО

Sapronova Margarita Rafailevna – Ph.D., associate Professor, Department of medical genetics and clinical neurophysiology

Krasnoyarsk

sapronova.mr@yandex.ruЯковлеваК. Д.YarovlevaK. D.

Яковлева Кристина Дмитриевна – аспирант

Yarovleva Kristina Dmitrievna – postgraduate student, laboratory assistant, Department of medical genetics and clinical neurophysiology

Krasnoyarsk

Kris_995@mail.ruУсольцеваА. А.UsoltsevaA. A.

Усольцева Анна Александровна - клинический ординатор, лаборант

Usoltseva Anna Alexandrovna – the resident, laboratory assistant, Department of medical genetics and clinical neurophysiology

Krasnoyarsk

a.usoltseva@list.ruПанинаЮ. С.PaninaJ. S.

Панина Юлия Сергеевна – н.с.

Panina Julia Sergeevna – research scientist, Department of medical genetics and clinical neurophysiology of Institute of postgraduate education

Krasnoyarsk

mrs.yuliapanina@mail.ruДмитренкоД. В.DmitrienkoD. V.

Дмитренко Диана Викторовна – д.м.н., зав. Кафедрой

Dmitrienko Diana Viktorovna – MD, Ph. D., head of the Department of medical genetics and clinical neurophysiology

Krasnoyarsk

mart2802@yandex.ruЗобоваС. Н.ZobovaS. N.

Зобова Светлана Николаевна – к.м.н., н.с. ИПО

Zobova Svetlana Nikolaevna – Ph. D, research scientist, Department of medical genetics and clinical neurophysiology

Krasnoyarsk

snzobova80@gmail.comФГБОУ ВО «КрасГМУ им. проф. В.Ф. Войно-Ясенецкого» Минздрава РоссииРоссияV.F. Voyno-Yasenetsky Krasnoyarsk State Medical UniversityRussian FederationФГБОУ ВО «КрасГМУ им. проф. В.Ф. Войно-Ясенецкого» Минздрава России; ФГБНУ ФИЦ «Красноярский научный центр СО РАН»», обособленное подразделение «НИИ медицинских проблем Севера»РоссияInstitute of postgraduate education V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences, the Separate Division «Research Institute of Medical Problems of the North»Russian Federation20200206202504106111Copyright © Сапронова М.Р., Яковлева К.Д., Усольцева А.А., Панина Ю.С., Дмитренко Д.В., Зобова С.Н., 20252025Сапронова М.Р., Яковлева К.Д., Усольцева А.А., Панина Ю.С., Дмитренко Д.В., Зобова С.Н.Sapronova M.R., Yarovleva K.D., Usoltseva A.A., Panina J.S., Dmitrienko D.V., Zobova S.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/737

В обзоре литературы рассматривается использование микроРНК как возможного биомаркера эпилепсии.Представленные исследования показали, что микроРНК могут быть вовлечены в процесс эпилептогенеза путем регулирования воспалительного ответа, апоптоза нейронов и факторов транскрипции, участвующих в дифференцировке клеток. Биологические жидкости (кровь и ликвор) пациентов с эпилепсией показали различия в количестве циркулирующих микроРНК, что, возможно, позволит в дальнейшем использовать микроРНК как диагностический биомаркер. Последние открытия обеспечивают богатый источник новых мишеней микроРНК, но остаются существенные проблемы изучения их роли в патогенезе и возможности применения в клинической практике.

This article considers the use of microRNAs as a possible biomarker of epilepsy.The presented studies have shown that microRNAs can be involved in the process of epileptogenesis by regulating the inflammatory response, apoptosis of neurons, and transcription factors involved in cell differentiation. Biological fluids (blood and CSF) of patients with epilepsy showed differences in the number of circulating microRNAs, which may allow further use of microRNAs as a diagnostic biomarker. Recent discoveries providethe sufficient source of new microRNA targets, but there are still significant problems of studying their role in pathogenesis and the possibility of their application in clinical practice.

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The authors declare that there are no conflicts of interest present.