ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2020.72.18ymj-729Research ArticleАКТУАЛЬНАЯ ТЕМАACTUAL TOPICАнализ клинических исходов у пациентов с гастродуоденальными заболеваниями в зависимости от вариантов гена vacA Helicobacter pylori в ЯкутииAnalysis of clinical outcomes in patients with gastroduodenal diseases depending on vacA Helicobacter pylori gene variants in Yakutiahttps://orcid.org/0000-0002-4710-1592ГотовцевН. Н.GotovtsevN. N.

Готовцев Ньургун Наумович – н.с.

Gotovtsev Nyurgun Naumovich – scientific researcher, Laboratory of Molecular Genetics

677010, Sakha Republic, Yakutsk, Sergelyakhskoye Shosse, 4. Phone: 89141062015

Donzcrew@mail.ruhttps://orcid.org/0000-0002-6984-7934БарашковН. А.BarashkovN. A.

Барашков Николай Алексеевич – к.б.н., в.н.с.-руковод. лаб.

Barashkov Nikolay Alekseevich – Candidate of biological sciences, Head of laboratory of Molecular genetics

677010, Sakha Republic, Yakutsk, Sergelyakhskoye Shosse, 4. Phone: 8-(4112) 32-19-81

barashkov2004@mail.ruhttps://orcid.org/0000-0001-6866-9462ПшенниковаВ. Г.PshennikovaV. G.

Пшенникова Вера Геннадиевна – к.б.н., в.н.с.-руковод. лаб.

Pshennikova Vera Gennadievna – Candidate of Biological Sciences, Head of laboratory of Populational Genetics

677010, Sakha Republic, Yakutsk, Sergelyakhskoye Shosse, 4. Phone: 8-(4112) 32-19-81

pshennikovavera@mail.ruБорисоваТ. В.BorisovaT. V.

Борисова Туяра Валерьевна – аспирант ИЕН

Borisova Tuyara Valerievna – student, Institute of Natural Sciences

677000, Yakutsk, Kulakovsky st. 48. Phone: 89644290223

borisovatv96@gmail.comЛехановаС. Н.LekhanovaS. N.

Леханова Саргылана Николаевна – к.м.н., доцент МИ

Lekhanova Sargylana Nikolaevna – Candidate of Medical Science, Associate Professor, Medical Institute

677010, Yakutsk, Oyunsky st. 27. Phone: 8-(4112) 36-30-46

lehanovasn@mail.ruФедороваС. А.FedorovaS. A.

Федорова Сардана Аркадьевна – д.б.н., зав. науч.-иссл. лаб. ИЕН

Fedorova Sardana Arkadievna – Doctor of biological sciences, Head of the Research Laboratory of Molecular Biology Institute of Natural Sciences

677010, Sakha Republic, Yakutsk, Kulakovsky st. 46.

sardaanafedorova@mail.ruПакМ. В.PakM. V.

Пак Мария Владимировна – врач-эндоскопист

Pak Maria Vladimirovna – endoscopist of the endoscopic department

677010, Sakha Republic, Yakutsk, Sergelyakhskoye Shosse, 4

pakmv@mail.ruАлексееваМ. П.AlexeevaM. P.

Алексеева Мавра Павловна – врач-эндоскопист

Alexeeva Mavra Pavlovna – endoscopist of the endoscopic department

677010, Sakha Republic, Yakutsk, Sergelyakhskoye Shosse, 4

ЛоскутоваК. С.LoskutovaK. S.

Лоскутова Кюнняй Саввична – к.м.н., зав. отд.

Loskutova Kiunniai Savvichna – Candidate of Medical Science, Head of the Pathoanatomical department

677010, Sakha Republic, Yakutsk, Sergelyakhskoye Shosse, 4

loskutovaks@mail.ruЯНЦ КМПРоссияFederal State Budgetary Scientific Institution "Yakut Science Center of Complex Medical Problems"Russian FederationЯНЦ КМПРоссияFederal State Budgetary Scientific Institution "Yakutsk Scientific Center of Complex Medical Problems"Russian FederationЯНЦ КМПРоссияFederal State Budgetary Scientific Institution "Yakutsk Scientific Center for Complex Medical Problems"Russian FederationСВФУ им. М.К. АммосоваРоссияFederal State Autonomous Educational Institution of Higher Education "North-Eastern Federal University. M.K. Ammosov "Russian FederationСВФУ им. М.К. АммосоваРоссияFederal State Autonomous Educational Institution of Higher Education "North-Eastern Federal University M.K. Ammosov"Russian FederationРБ№1-НЦМРоссияRepublican Hospital No. 1 National Center of MedicineRussian Federation202002062025046973Copyright © Готовцев Н.Н., Барашков Н.А., Пшенникова В.Г., Борисова Т.В., Леханова С.Н., Федорова С.А., Пак М.В., Алексеева М.П., Лоскутова К.С., 20252025Готовцев Н.Н., Барашков Н.А., Пшенникова В.Г., Борисова Т.В., Леханова С.Н., Федорова С.А., Пак М.В., Алексеева М.П., Лоскутова К.С.Gotovtsev N.N., Barashkov N.A., Pshennikova V.G., Borisova T.V., Lekhanova S.N., Fedorova S.A., Pak M.V., Alexeeva M.P., Loskutova K.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/729

В статье приводятся результаты изучения клинических исходов у пациентов с гастродуоденальными заболеваниями в зависимости от вариантов гена vacA Helicobacter pylori в Якутии. Не выявлено ассоциаций в зависимости от пола пациентов, их места рождения или проживания. Однако статистически значимые отличия в распределении аллелей гена vacA были найдены в зависимости от пациентов с хроническим гастритом сопровождаемые эрозиями и язвами. Полученные результаты согласуются с результатами работ других исследователей.

A vacA gene is important virulence factor that encodes vacuolating toxin and presents in all strains of Helicobacter pylori. There is significant difference between strains in vacuolating activity determined by different sequences in the middle (m) and signal (s) regions. Helicobacter pylori vacAm has m1 and m2 alleles, vacAs has s1 and s2 alleles. The higher grade of cytotoxic activity shows Helicobacter pylori with vacAs1m1 strains than s1m2, while s2m2 has not produced vacuolating cytotoxin. The effect of vacA gene alleles on gastroduodenal diseases in patients of Yakutia earlier has not been studied. The aim of this work is an associative analysis of the clinical outcomes of the vacA Helicobacter pylori variant gene and its association with the course of gastroduodenal diseases among Yakuts. According to the results of the histological report, 154 patients (out of 322 examined) were included in the study, who had H. pylori in the antrum of the stomach. Patients were divided into two groups: chronic gastri tis (n=65) and chronic gastritis with erosive and ulcerative lesions (n=89). The average age was 26,6 years. The diagnosis of chronic gastritis was established in 65 cases (42,2%), and chronic gastritis with erosive and ulcerative lesions was diagnosed in 89 cases (57,7%). A vacAs1m1 was found in 30 out of 39 patients with erosive and ulcerative lesions (76,9%) (p< 0,05) and 9 out of 39 patients – in the sample with chronic gastritis (23,1%) (p< 0,05). Other patients (n=115) did not have statistically significant differences in comparable groups. High percentage of vacAs1m1 alleles in patients with erosive gastritis in Yakutia suggests the hypothesis that this strain is the most cytotoxic and more common for severe forms of gastritis in peptic ulcer disease.

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The authors declare that there are no conflicts of interest present.