ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2020.72.06ymj-716Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHСоотношение уровня некроза и апоптоза нейтрофилов периферической крови у практически здоровых северянThe ratio of peripheral blood neutrophils necrosis to apoptosis in apparently healthy northernersСтавинскаяО. А.StavinskayaO. A.

Ставинская Ольга Александровна – к.б.н., с.н.с.

Stavinskaya Olga Aleksandrovna - PhD (Biol.), senior researcher

Arkhangelsk

ifpa-olga@mail.ruДобродееваЛ. К.DobrodeevaL. K.

Добродеева Лилия Константиновна – д.м.н., проф., гл.н.с.

Dobrodeeva Liliya Konstantinovna - Doctor of Medical Sciences, Professor, Chief Researcher

Arkhangelsk

dobrodeevalk@mail.ruБалашоваС. Н.BalashovaS. N.

Балашова Светлана Николаевна – к.б.н., с.н.с.

Balashova Svetlana Nikolaevna - PhD (Biol.), senior researcher

Arkhangelsk

ifpa-svetlana@mail.ruПатракееваВ. П.PatrakeevaV. P.

Патракеева Вероника Павловна – к.б.н., в.н.с.

Patrakeeva Veronika Pavlovna - PhD (Biol.), Leading Researcher

Arkhangelsk

patrakeewa.veronika@yandex.ruФГБУН ФИЦ комплексного изучения Арктики им. акад. Н.П. Лавёрова Уральского отделения РАН, Институт физиологии природных адаптаций г. АрхангельскРоссияN. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of SciencesRussian Federation202002062025042327Copyright © Ставинская О.А., Добродеева Л.К., Балашова С.Н., Патракеева В.П., 20252025Ставинская О.А., Добродеева Л.К., Балашова С.Н., Патракеева В.П.Stavinskaya O.A., Dobrodeeva L.K., Balashova S.N., Patrakeeva V.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/716

Изучены пределы и соотношение активности апоптоза и некроза нейтрофильных гранулоцитов в венозной периферической крови у практически здоровых людей. Установлено, что при увеличении содержания некротизированных нейтрофилов AnV+/PI+ статистически значимо растет концентрация апоптотических клеток AnV+/PI- на фоне сокращения числа циркулирующих нейтрофилов, моноцитов и Т-хелперов. Таким образом, активизация гибели нейтрофилов путем некроза может стать патогенетическим механизмом повреждения клеточных мембран (ядерной, лизосомальных или клеточной), а также формирования Т-хелперных иммунодефицитов.

The limits and correlation of apoptosis and necrosis of neutrophil granulocytes in venous peripheral blood in apparently healthy people were studied. It was found that w contehen increasing the content of necrotic neutrophils AnV+/PI+, the concentration of apoptotic cells AnV+/PI-increases statistically to a large extent associated with the reduction of circulating neutrophils, monocytes, and t-helper cells. Thus, activation of neutrophil loss by necrosis can become a pathogenetic mechanism of cell membrane damage (nuclear, lysosomal, or cellular), as well as the formation of T-helper immunodeficiency.

некроз и апоптоз нейтрофиловлимфоцитыцитокиныиммуноглобулиныпрактически здоровые людиneutrophil necrosis and apoptosislymphocytescytokinesimmunoglobulinsapparently healthy peopleРабота выполнена в рамках программы фундаментальных научных исследований по теме лаборатории экологической иммунологии Института физиологии природных адаптаций ФГБУН ФИЦКИА УрО РАН № гос. регистрации АААА-А17-117033010124-7.The work was carried out within the framework of the program of fundamental scientific research on the topic of the laboratory of Environmental Immunology of the Institute of Physiology of Natural Adaptations of FCIARCTIC UrO RAS № State Registration of АААА-А17-117033010124-7.ReferencesГерасимов И.Г. Субпопуляции нейтрофилов периферической крови и возможности НСТ-теста в диагностике заболеваний новорожденных / И.Г. Герасимов // Клин. лаб. диагн. – 2011. – № 4. – С. 42-44.Gerasimov I.G. Peripheral blood neutrophil subpopulation and NST test capabilities in neonatal disease diagnosis / I.G. 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The authors declare that there are no conflicts of interest present.