ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2020.72.04ymj-714Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHУровень циркулирующего в крови лептина у молодых якутов в зависимости от индекса массы телаCirculating levels of leptin in blood of young Yakuts depending on the body mass indexhttps://orcid.org/0000-0002-7129-6633НиканороваА. А.NikanorovaA. A.

Никанорова Алена Афанасьевна – м.н.с.

Nikanorova Alеna Afanasyevna – junior researcher, Laboratory of Molecular Genetics

677010, Sakha Republic, Yakutsk, Sergelyakhskoye Shosse, 4. Phone: 89244611585

nikanorova.alena@mail.ruhttps://orcid.org/0000-0002-4710-1592ГотовцевН. Н.GotovtsevN. N.

Готовцев Ньургун Наумович – н.с.

Gotovtsev Nyurgun Naumovich – Scientific researcher, Laboratory of Molecular Genetics

677010, Sakha Republic, Yakutsk, Sergelyakhskoye Shosse, 4. Phone: 89141062015

Donzcrew@mail.ruhttps://orcid.org/0000-0002-6984-7934БарашковН. А.BarashkovN. A.

Барашков Николай Алексеевич – к.б.н., в.н.с. -руковод. лаб.

Barashkov Nikolay Alekseevich – Candidate of biological sciences, Head of laboratory of Molecular genetics

677010, Sakha Republic, Yakutsk, Sergelyakhskoye Shosse, 4. Phone: 8-(4112) 32-19-81

barashkov2004@mail.ruhttps://orcid.org/0000-0001-6866-9462ПшенниковаВ. Г.PshennikovaV. G.

Пшенникова Вера Геннадиевна – к.б.н., в.н.с. -руковод. лаб.

Pshennikova Vera Gennadievna – Candidate of Biological Sciences, Head of laboratory of Populational Genetics

677010, Sakha Republic, Yakutsk, Sergelyakhskoye Shosse, 4. Phone: 8-(4112) 32-19-81

pshennikovavera@mail.ruhttps://orcid.org/0000-0002-6917-5760НаходкинС. С.NakhodkinS. S.

Находкин Сергей Сергеевич – н.с.

Nakhodkin Sergey Sergeyevich – Engineer-researcher of the Research Laboratory of Molecular Biology Institute of Natural Sciences

677010, Sakha Republic, Yakutsk, Kulakovsky st. 46.

sergnahod@mail.ruhttps://orcid.org/0000-0002-0664-4224СоловьевА. В.SolovyevA. V.

Соловьев Айсен Васильевич – к.б.н., с.н.с.

Solovyev Aisen Vasilyevich – Candidate of Biological Sciences, junior researcher, of the Research Laboratory of Molecular Biology Institute of Natural Sciences

677010, Sakha Republic, Yakutsk, Kulakovsky st. 46.

nelloann@mail.ruhttps://orcid.org/0000-0002-4687-4868КузьминаС. С.KuzminaS. S.

Кузьмина Саргылана Семеновна – к.б.н., доцент

Kuzmina Sargylana Semenovna – Candidate of Biological Sciences, Associate Professor, Department of Biology

677000, Sakha Republic, Yakutsk, Kulakovsky st. 48.

sskuzmina@bk.ruСазоновН. Н.SazonovN. N.

Сазонов Николай Никитич – д.б.н., проф.

Sazonov Nikolay Nikitich – Doctor of biological sciences, Professor, Department of Biology

677000, Sakha Republic, Yakutsk, Kulakovsky st. 48.

nn.sazonov@s-vfu.ruhttps://orcid.org/0000-0002-6952-3868ФедороваС. А.FedorovaS. A.

Федорова Сардана Аркадьевна – д.б.н., зав. лаб.

Fedorova Sardana Arkadievna – Doctor of biological sciences, Head of the Research Laboratory of Molecular Biology Institute of Natural Sciences

677010, Sakha Republic, Yakutsk, Kulakovsky st. 46.

sardaanafedorova@mail.ruЯНЦ КМПРоссияFederal State Budgetary Scientific Institution "Yakut Science Center of Complex Medical Problems"Russian FederationЯНЦ КМПРоссияFederal State Budgetary Scientific Institution "Yakutsk Scientific Center of Complex Medical Problems"Russian FederationЯНЦ КМПРоссияFederal State Budgetary Scientific Institution "Yakutsk Scientific Center for Complex Medical Problems"Russian FederationИнститут естественных наук СВФУ им. М.К. АммосоваРоссияFederal State Autonomous Educational Institution of Higher Education "North-Eastern Federal University M.K. Ammosov"Russian FederationИнститут естественных наук СВФУ им. М.К. АммосоваРоссияThe Institute of Natural Sciences "North-Eastern Federal University M.K. Ammosov"Russian Federation202002062025041619Copyright © Никанорова А.А., Готовцев Н.Н., Барашков Н.А., Пшенникова В.Г., Находкин С.С., Соловьев А.В., Кузьмина С.С., Сазонов Н.Н., Федорова С.А., 20252025Никанорова А.А., Готовцев Н.Н., Барашков Н.А., Пшенникова В.Г., Находкин С.С., Соловьев А.В., Кузьмина С.С., Сазонов Н.Н., Федорова С.А.Nikanorova A.A., Gotovtsev N.N., Barashkov N.A., Pshennikova V.G., Nakhodkin S.S., Solovyev A.V., Kuzmina S.S., Sazonov N.N., Fedorova S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/714

Проведена оценка уровня циркулирующего в крови лептина в зависимости от индекса массы тела (ИМТ) у молодых здоровых якутов. Общая выборка была разделена на три группы по показателям ИМТ: лица с дефицитом массы тела, нормальной массой тела, избытком массы тела или ожирением. Между мужчинами и женщинами в группах статистически значимых различий в ИМТ не обнаружено. Выявлено, что как у женщин, так и у мужчин уровни лептина были статистически выше у лиц с избытком массы тела/ ожирением по сравнению с двумя другими группами. Между группами лиц с дефицитом массы тела и нормой как у женщин, так и у мужчин статистически значимых различий в уровнях лептина не выявлено, что может быть связано с защитой организма от низких температур посредством развития активной бурой жировой ткани, секретирующей дополнительный лептин.

The aim of this study is to evaluate the leptin level circulating in blood serum depending on the body mass index (BMI) in young healthy Yakuts (mean age 19.8±1.5 years). The total sample (n=281) was divided into three groups according to the WHO classification: persons with underweight, normal, overweight / obese. There were no statistically significant differences in BMI between men and women in the groups. As a result of the comparative analysis, it was found that both in women and in men, leptin levels were statistically higher in overweight/obese individuals compared with the other two groups. There were no statistically significant differences in leptin levels between the groups of people with underweight and normal weight, both in women and in men, which could be associated with the body's protection from low temperatures through the development of active brown adipose tissue, secreting additional leptin.

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The authors declare that there are no conflicts of interest present.