ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2022.79.13ymj-70Research ArticleГИГИЕНА, САНИТАРИЯ, ЭПИДЕМИОЛОГИЯ И МЕДИЦИНСКАЯ ЭКОЛОГИЯHYGIENE, SANITATION, EPIDEMIOLOGY AND MEDICAL ECOLOGYИсследование индикатора воздействия ПАУ 1-гидроксипирена в моче у работников алюминиевого завода в Восточной СибириStudy of 1-hydroxypyrene PAH exposure in urine of workers of the aluminum smelter in Eastern Siberiahttps://orcid.org/0000-0001-8740-3133ШаяхметовC. Ф.ShayakhmetovS. F.

Шаяхметов Салим Файзыевич – д.м.н., проф., в.н.с.

 

Shayakhmetov Salim Fayzyevich – MD, professor, leading researcher of the laboratory of analytical ecotoxicology and biomonitoring

 

salimf53@mail.ruhttps://orcid.org/0000-0003-4980-5304АлексеенкоА. Н.AlexeenkoA. N.

Алексеенко Антон Николаевич – к.х.н., с.н.с.

 

Alekseenko Anton Nikolaevich – PhD in Chemistry, senior researcher of analytical ecotoxicology and biomonitoring laboratory

 

alexeenko85@mail.ruhttps://orcid.org/0000-0001-7848-6432МериновА. В.MerinovA. V.

Меринов Алексей Владимирович – к.б.н., м.н.с.

 

Merinov Alexey Vladimirovich – PhD of Biology, junior researcher of analytical ecotoxicology and biomonitoring laboratory

 

alek-merinov@mail.ruhttps://orcid.org/0000-0002-9961-6408ЖурбаО. М.ZhurbaO. M.

Журба Ольга Михайловна – к.б.н., с.н.с., зав. лаб.

 

Zhurba Olga Mikhaylovna – PhD of Biology, head of analytical ecotoxicology and biomonitoring laboratory

 

zhurba99@gmail.comФГБНУ «Восточно-Сибирский институт медико-экологических исследований»РоссияEast-Siberian Institute of Medical and Ecological ResearchRussian Federation202203022025035052Copyright © Шаяхметов C.Ф., Алексеенко А.Н., Меринов А.В., Журба О.М., 20252025Шаяхметов C.Ф., Алексеенко А.Н., Меринов А.В., Журба О.М.Shayakhmetov S.F., Alexeenko A.N., Merinov A.V., Zhurba O.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/70

Представлены результаты исследований содержания маркерного метаболита ПАУ 1-гидроксипирена (1-OHPyr) в моче у работников основных и вспомогательных профессий современного алюминиевого производства. Наибольшие уровни 1-ОНРyr, характеризующие внутренние нагрузки ПАУ, и связанный с ними высокий риск нарушений здоровья установлены у анодчиков при традиционной технологии получения алюминия с самообжигающимися анодами.

Aim

Aim: to study the content of the biomarker of PAH exposure – 1-hydroxypyrene (1-OHPyr) in the urine of workers in modern aluminum production in Eastern Siberia.

Materials and methods

Materials and methods. 159 workers of electrolysis workshops with the technology of self-baked and pre-baked anodes were examined. The I group included 142 workers of the main professions engaged in the servicing of electrolyzers, anodes and cranes, the group II included 17 workers of auxiliary professions for pouring metal. The control group consisted of 14 people. Determination of 1-OHPyr was carried out by chromato-mass-spectrometry on an Agilent 7890A gas chromatograph. The data was processed in the Statictica 6.1 program.

Results

Results. Significant differences were established between the median levels of 1-OHPyr in urine among workers of the main (2.2–75.2 µg/l) and auxiliary (0.48–7.6 µg/l) occupations in comparison with the values of the control group (0.17 µg/l) and Biological Exposure Index (2.5 µg/l, AGGIH 2020). The concentrations of 1-OHPyr in anodes workers were 6.4-20.9 times higher than those of electrolyzers workers and crane operators, and 9.9-156.7 times higher than the levels of auxiliary professions. The lowest concentrations of 1-OHPyr were found in urine samples of workers operators of workshops with the technology of pre-baked anodes.

Conclusion

Conclusion. The research results confirmed the increased professional impact of PAHs on aluminum production workers. The highest levels of 1-OHPyr in urine, characterizing the internal loads of PAHs and the associated high risk of health disorders, were found in operators servicing anodes of workshops with the technology of self-baked anodes.

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The authors declare that there are no conflicts of interest present.