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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25789/YMJ.2020.70.19</article-id><article-id custom-type="elpub" pub-id-type="custom">ymj-688</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНАЯ ТЕМА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ACTUAL TOPIC</subject></subj-group></article-categories><title-group><article-title>Взаимосвязь когнитивных нарушений с клиническими особенностями алкогольной зависимости</article-title><trans-title-group xml:lang="en"><trans-title>Relationship of cognitive disorders with clinical features of alcohol dependence</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7709-3917</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Галкин</surname><given-names>C. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Galkin</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Галкин Станислав Алексеевич – аспирант</p></bio><bio xml:lang="en"><p>Galkin Stanislav A. – PhD Student</p><p>4, Aleutskaya Str., Tomsk, 634014</p></bio><email xlink:type="simple">s01091994@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3951-395X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пешковская</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Peshkovskaya</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пешковская Анастасия Григорьевна – м.н.с.</p></bio><bio xml:lang="en"><p>Peshkovskaya Anastasia G. – Researcher</p><p>4, Aleutskaya Str., Tomsk, 634014</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2246-7045</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рощина</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Roshchina</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рощина Ольга Вячеславовна – м.н.с.</p></bio><bio xml:lang="en"><p>Roshchina Olga V. – Researcher</p><p>4, Aleutskaya Str., Tomsk, 634014</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5607-7491</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кисель</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kisel</surname><given-names>N. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кисель Наталья Игоревна – к.м.н.</p></bio><bio xml:lang="en"><p>Kisel Nataliya I. – PhD</p><p>4, Aleutskaya Str., Tomsk, 634014</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7078-323X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванова</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanova</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иванова Светлана Александровна – д.м.н., проф., зав. лаб., зам. директора по науч. Работе</p></bio><bio xml:lang="en"><p>Ivanova Svetlana A. – DM, Professor, Head of the Laboratory of Molecular Genetics and Biochemistry, Deputy Director for Science</p><p>4, Aleutskaya Str., Tomsk, 634014</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1052-855X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бохан</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bokhan</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бохан Николай Александрович – д.м.н., академик РАН, проф., директор института;</p><p>зав. Кафедрой</p></bio><bio xml:lang="en"><p>Bokhan Nikolay A. – DM, Professor, Аcademician of the Russian Academy of Sciences academician, RAS, Director</p><p>4, Aleutskaya Str., Tomsk, 634014;</p><p>head of the Department of psychiatry, psychotherapy, narcology with the course med. the psychology</p><p>2, Moscow Trakt, Tomsk, 634050</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>НИИ психического здоровья, Томский национальный исслед. медицин. центр РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Mental Health Research Institute, Tomsk National Research Medical Center (NRMC) of the Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>НИИ психического здоровья, Томский национальный исслед. медицин. центр РАН;&#13;
Сибирский ГМУ МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Mental Health Research Institute, Tomsk National Research Medical Center (NRMC) of the Russian Academy of Sciences;&#13;
Siberian State Medical University of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>17</day><month>05</month><year>2025</year></pub-date><volume>0</volume><issue>2</issue><fpage>62</fpage><lpage>65</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Галкин C.А., Пешковская А.Г., Рощина О.В., Кисель Н.И., Иванова С.А., Бохан Н.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Галкин C.А., Пешковская А.Г., Рощина О.В., Кисель Н.И., Иванова С.А., Бохан Н.А.</copyright-holder><copyright-holder xml:lang="en">Galkin S.A., Peshkovskaya A.G., Roshchina O.V., Kisel N.I., Ivanova S.A., Bokhan N.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/688">https://ymj.elpub.ru/jour/article/view/688</self-uri><abstract><p>Для выявления взаимоотношения между показателями когнитивного функционирования и клиническими особенностями формирования и течения алкогольной зависимости проведено исследование в группе пациентов с алкогольной зависимостью после детоксикации.Выявлено, что при алкогольной зависимости происходит гетерогенное изменение уровня когнитивного функционирования: нарушение ингибиторного контроля, снижение объема пространственной рабочей памяти, внимания и когнитивной гибкости. Обнаружены статистически значимые корреляции между клиническими данными и степенью нарушения когнитивного функционирования.Таким образом, более ранний возраст первой пробы алкоголя существенно оказывает влияние на снижение тормозного контроля, что повышает риск формирования алкогольной зависимости уже в молодом возрасте. Давность алкогольной зависимости и связанное с этим количество госпитализаций приводят к нарушению когнитивного функционирования в виде снижения объема пространственной рабочей памяти и когнитивной гибкости. Тяжесть течения алкогольной зависимости определяет в первую очередь степень снижения когнитивной гибкости.</p></abstract><trans-abstract xml:lang="en"><p>The study was conducted in a group of patients with alcohol dependence after detoxification to identify the relationship between indicators of cognitive functioning and clinical features of the formation and course of alcohol dependence.It was found that alcohol dependence causes a heterogeneous change in the level of cognitive functioning: violation of inhibitory control, decrease in the volume of spatial working memory, attention and cognitive flexibility. Statistically significant correlations were found between clinical data and the degree of cognitive impairment.Thus, the earlier age of the first sample of alcohol significantly affects the reduction of brake control, which increases the risk of forming alcohol dependence at a young age. The age of alcohol dependence and the associated number of hospitalizations leads to impaired cognitive functioning in the form of reduced spatial working memory and cognitive flexibility. The severity of alcohol dependence primarily determines the degree of cognitive flexibility decline.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>алкогольная зависимость</kwd><kwd>когнитивное функционирование</kwd><kwd>клиника</kwd><kwd>память</kwd><kwd>ингибиторный контроль</kwd></kwd-group><kwd-group xml:lang="en"><kwd>alcohol dependence</kwd><kwd>cognitive functioning</kwd><kwd>clinic</kwd><kwd>memory</kwd><kwd>inhibitory control</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено при финансовой поддержке Администрации Томской области и РФФИ №19-413- 703007.</funding-statement><funding-statement xml:lang="en">The study was carried out with the financial support of the Tomsk region Administration and RFBR 19-413-703007.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Галкин С.А. 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