ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2024.87.20ymj-68Research ArticleАРКТИЧЕСКАЯ МЕДИЦИНАARCTIC MEDICINEАнализ уровня кортизола и дегидроэпиандростерона-сульфата у мужчин-северян: влияние поколения проживания в условиях севераAnalysis of cortisol and dehydroepiandrosterone-sulfate levels in male northerners: the influence of generation living in the northhttps://orcid.org/0000-0002-4511-6782АверьяноваИ. В.AveryanovaI. V.

Аверьянова Инесса Владиславовна – д.б.н., гл.н.с., зав. лаб.

Averyanova Inessa Vladislavovna – Doctor in Biology, head of the laboratory, chief researcher of the Laboratory of Physiology

Inessa1382@mail.ruhttps://orcid.org/0000-0002-5718-5398АлёшинаО. О.AlyoshinaO. O.

Алёшина Ольга Олеговна – м.н.с.

Alyoshina Olga Olegovna – junior scientist at the Laboratory of the Physiology

oalesina597@gmail.comНИЦ «Арктика» Дальневосточного отделения РАНРоссияExtreme Conditions Scientific Research Center “Arktika”, Fareastern Branch of the Russian Academy of Sciences (SRC “Arktika” FEB RAS)Russian Federation2024030220250399103Copyright © Аверьянова И.В., Алёшина О.О., 20252025Аверьянова И.В., Алёшина О.О.Averyanova I.V., Alyoshina O.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/68

Цель исследования выявление региональных особенностей, а также оценка изменений среднего уровня кортизола и дегидроэпиандростерона-сульфата у мужчин-северян в зависимости от поколения проживания в условиях Севера.

В общую выборку были включены мужчины (средний возраст 40,0±0,8 года), постоянно проживающие на территории Магаданской области.

Показано, что сывороточные концентрации кортизола и дегидроэпиандростерона-сульфата, их соотношение, а также кортизол в вечерней порции слюны являются значимыми маркерами, отражающими перестройки эндокринного профиля при возрастании стажа проживания в условиях Севера, что подтверждает общепризнанную роль глюкокортикоидов при адаптации человека к экстремальным факторам, в том числе и климатогеографическим.

The aim of the study is to identify regional characteristics and to assess changes in the mean level of cortisol and dehydropepenandrosterone-sulphate in male northerners according to the generation living in the North.

The total sample included male residents (average age 40.0 0.8 years) permanently residing in the territory of Magadan region.

The study has resulted in referring serum cortisol and dehydroepiandrosterone-sulfate concentrations, their ratio, as well as cortisol concentrations in the evening saliva tests to significant markers that reflect readjustments in the endocrine picture with increasing length of residence in the North, thus confirming the generally recognized role of glucocorticoids in hormonal support of the body adaptation to extreme factors including climatic environments.

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The authors declare that there are no conflicts of interest present.