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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25789/YMJ.2021.76.20</article-id><article-id custom-type="elpub" pub-id-type="custom">ymj-604</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНАЯ ТЕМА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ACTUAL TOPIC</subject></subj-group></article-categories><title-group><article-title>Постковидный синдром хронической усталости и нарушения эмоциональной сферы у жителей г. Якутска</article-title><trans-title-group xml:lang="en"><trans-title>Post-COVID 19 syndrome of chronic fatigue and emotional disorders in residents of Yakutsk</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Варламова</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Varlamova</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Варламова Марина Алексеевна – н.с., врач невролог Клиники ЯНЦ КМП</p></bio><bio xml:lang="en"><p>Varlamova Marina Alekseevna – research associate, neurologist of the Clinic of YSC CMP</p></bio><email xlink:type="simple">varlamova.m@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Давыдова</surname><given-names>Т. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Davydova</surname><given-names>T. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Давыдова Татьяна Кимовна – к.м.н., в.н.с.-руковод. лаб.</p></bio><bio xml:lang="en"><p>Davydova Tatyana Kimovna – Candidate of Medical Sciences, associate researcher, head of the lab.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Олесова</surname><given-names>Л. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Olesova</surname><given-names>L. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Олесова Любовь Дыгыновна – к.б.н., в.н.с.-руковод. лаб.</p></bio><bio xml:lang="en"><p>Olesova Lyubov Dygynovna –Candidate of Biological Sciences, associate researcher, head of the lab.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Макарова</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Makarova</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Макарова Виктория Алексеевна – гл. врач</p><p>г. Якутск</p></bio><bio xml:lang="en"><p>Makarova Victoria Alekseevna – chief physician</p><p>Yakutsk</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Якутский НЦ комплексных медицинских проблем</institution><country>Россия</country></aff><aff xml:lang="en"><institution>YSC CMP</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Клиника «Дельта»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Delta Clinic</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>04</day><month>05</month><year>2025</year></pub-date><volume>0</volume><issue>4</issue><fpage>86</fpage><lpage>89</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Варламова М.А., Давыдова Т.К., Олесова Л.Д., Макарова В.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Варламова М.А., Давыдова Т.К., Олесова Л.Д., Макарова В.А.</copyright-holder><copyright-holder xml:lang="en">Varlamova M.A., Davydova T.K., Olesova L.D., Makarova V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/604">https://ymj.elpub.ru/jour/article/view/604</self-uri><abstract><p>Проведен анализ синдрома хронической усталости и уровня тревоги и депрессии у пациентов в возрасте от 20 до 72 лет, перенесших острую инфекцию COVID-19 от 3 до 12 мес. назад к моменту исследования. Женщины молодого и среднего возраста более подвержены вирусной пневмонии COVID-19 в тяжелой и критически тяжелой форме. Тяжелее перенесли COVID-19 по сравнению с женщинами мужчины в возрасте 32-51 и 61-70 лет. Тревожно-депрессивные расстройства и синдром хронической усталости могут развиться на любом сроке постковидного периода от 3 мес. до 12 мес.</p></abstract><trans-abstract xml:lang="en"><p>The analysis of chronic fatigue syndrome and the level of anxiety and depression was conducted in 161 patients aged 20 to 72 years who had an acute infection with COVID-19 from 3 to 12 months ago. Young and middle-aged women are more susceptible to COVID-19 viral pneumonia in severe and critically severe form. Men are more severely affected by COVID-19 compared to women aged 32-51 and 61-70. Anxiety-depressive disorders and chronic fatigue syndrome can develop at any time in the post-ovarian period, from 3 months to 12 months.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>постковидный синдром</kwd><kwd>тревожно-депрессивный синдром</kwd><kwd>синдром хронической усталости</kwd><kwd>шкала HADS</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>postcoid syndrome</kwd><kwd>anxiety-depressive syndrome</kwd><kwd>chronic fatigue syndrome</kwd><kwd>HADS scale</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Данное исследование проведено в рамках инициативного проекта Якутского научного центра комплексных медицинских проблем «Комплексная оценка здоровья пациентов, перенесших новую короновирусную инфекцию (COVID-19)».</funding-statement><funding-statement xml:lang="en">This study was carried out as part of the initiative project of the Yakutsk Scientific Center for Complex Medical Problems "Comprehensive assessment of the health of patients who have undergone a new coronavirus infection (COVID-19)."</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Возможные подходы к терапии астенических и когнитивных нарушений при постковидном синдроме / А. Н. Боголепова, Н. А. Осиновская, Е. А. Коваленко, Е. В. Махнович // Неврология, нейропсихиатрия, психосоматика. – 2021. – Т. 13. – № 4. – С. 88-93. – DOI: 10.14412/2074-2711-2021-4-88-93.</mixed-citation><mixed-citation xml:lang="en">Bogolepova AN, Osinovskaya NA, Kovalenko EA, Makhnovich EV. Possible approaches to the therapy of asthenic and cognitive disorders in postcoid syndrome. Nevrologiya, nejropsihiatriya, psihosomatika. 2021; 13 (4): 88-93. - DOI: 10.14412/2074-2711-2021-4-88-93.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Постковидные неврологические синдромы / В.В. Белопасов, Е.Н. Журавлева, Н.П Нугманова [и др.]. - Клиническая практика. - 2021. - Т. 12. - №2. - C. 69-82. doi: 10.17816/clinpract71137.</mixed-citation><mixed-citation xml:lang="en">Belopasov VV, Zhuravleva EN, Nugmanova NP, et al. Postcovid neurological syndromes. Klinicheskaya practika. 2021; 12 (2): 69-82. doi: 10.17816/clinpract71137.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Психоэмоциональные расстройства и нарушения сна у пациентов с COVID-19 / М. А. Самушия, С.М. Крыжановский, А.А. Рагимова [и др.]. // Журнал неврологии и психиатрии им. С.С. Корсакова. – 2021. – Т. 121. – №4. – вып. 2. – С. 49-54. DOI: 10.17116/jnevro202112104249</mixed-citation><mixed-citation xml:lang="en">Samushia MA, Kryzhanovsky SM, Ragimov AA, et al. Psychoemotional disorders and sleep disorders in patients with COVID-19. Jhurnal Nevrologii i psykhiatrii im. S.S. Korsakova. 2021; 121 (4) 2: 49-54. DOI: 10.17116/jnevro202112104249</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Путилина М.В. Астенические расстройства как проявление синдрома хронической усталости // Журнал неврологии и психиатрии им. С.С. Корсакова. – 2021. – Т. 121. - №8. – С. 125-130 DOI: 10.17116/jnevro2021121081125</mixed-citation><mixed-citation xml:lang="en">Putilina MV. Asthenic disorders as a manifestation of chronic fatigue syndrome. Jhurnal nevrologii and psickiatrii im. S.S. Korsakov. 2021; 121(8): 125-130. DOI: 10.17116/jnevro2021121081125</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Davis HE, Assaf GS, McCorkell L, et al. Characterizing Long COVID in an International Cohort: 7 Months of Symptoms and Their Impact medRxiv preprint. doi: 10.1101/2020.12.24.20248802; this version posted April 5, 2021. Available from: https://www.medrxiv.org/content/10.1101/2020.12.24.20248802v3</mixed-citation><mixed-citation xml:lang="en">Davis HE, Assaf GS, McCorkell L, et al. Characterizing Long COVID in an International Cohort: 7 Months of Symptoms and Their Impact medRxiv preprint. doi: 10.1101/2020.12.24.20248802; this version posted April 5, 2021. Available from: https://www.medrxiv.org/content/10.1101/2020.12.24.20248802v3</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Nekaeva ES, Bolshakova AE, Malysheva ES, et al. Characteristics of the Novel Coronavirus Infection (COVID-19) in Middle-Aged Adults Gender. Sovrem Tekhnologii Med. 2021; 13(4): 16-24. doi: 10.17691/stm2021.13.4.02.</mixed-citation><mixed-citation xml:lang="en">Nekaeva ES, Bolshakova AE, Malysheva ES, et al. Characteristics of the Novel Coronavirus Infection (COVID-19) in Middle-Aged Adults Gender. Sovrem Tekhnologii Med. 2021; 13(4): 16-24. doi: 10.17691/stm2021.13.4.02.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Baig A, Khaleeq A, Ali U, et all. Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution. Host-Virus Interaction, and Proposed Neurotropic Mechanisms. ACS Chem Neurosc. 2020 Apr 1; 11(7):995-8. doi: 10.1021/acschemneuro.0c00122</mixed-citation><mixed-citation xml:lang="en">Baig A, Khaleeq A, Ali U, et all. Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution. Host-Virus Interaction, and Proposed Neurotropic Mechanisms. ACS Chem Neurosc. 2020 Apr 1; 11(7):995-8. doi: 10.1021/acschemneuro.0c00122</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Maltezou HC, Pavli A, Tsakris A. Post-COVID Syndrome: An Insight on Its Pathogenesis. Vaccines (Basel). 2021 May 12;9 (5):497. doi: 10.3390/vaccines9050497</mixed-citation><mixed-citation xml:lang="en">Maltezou HC, Pavli A, Tsakris A. Post-COVID Syndrome: An Insight on Its Pathogenesis. Vaccines (Basel). 2021 May 12;9 (5):497. doi: 10.3390/vaccines9050497</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Greenhalgh T, Knight M, A’Court M, et al. Management of post-acute COVID-19 in primary care. BMJ. 2020 Aug 11;370:m3026. doi: 10.1136/bmj.m3026</mixed-citation><mixed-citation xml:lang="en">Greenhalgh T, Knight M, A’Court M, et al. Management of post-acute COVID-19 in primary care. BMJ. 2020 Aug 11;370:m3026. doi: 10.1136/bmj.m3026</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Pavli A, Theodoridou M, Maltezou HC. Post-COVID syndrome: Incidence, clinical spectrum, and challenges for primary healthcare professionals Arch Med Res. 2021 May 4. S0188-4409(21)00081-3. doi: 10.1016/j.arcmed.2021.03.010. Online ahead of print.</mixed-citation><mixed-citation xml:lang="en">Pavli A, Theodoridou M, Maltezou HC. Post-COVID syndrome: Incidence, clinical spectrum, and challenges for primary healthcare professionals Arch Med Res. 2021 May 4. S0188-4409(21)00081-3. doi: 10.1016/j.arcmed.2021.03.010. Online ahead of print.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Goёrtz YMJ, van Herck M, Delbressine JM, et al. Persistent symptoms 3 months after a SARS-CoV-2 infection: the post-COVID-19 syndrome? ERJ Open Res. 2020 Oct 26;6(4):00542-2020. doi: 10.1183/23120541.00542-2020. eCollection 2020 Oct.</mixed-citation><mixed-citation xml:lang="en">Goёrtz YMJ, van Herck M, Delbressine JM, et al. Persistent symptoms 3 months after a SARS-CoV-2 infection: the post-COVID-19 syndrome? ERJ Open Res. 2020 Oct 26;6(4):00542-2020. doi: 10.1183/23120541.00542-2020. eCollection 2020 Oct.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Amenta EM, Spallone A, Rodriguez-Barradas MC, et al. Post-acute COVID-19: An overview and approach to classification. Open Forum Infect Dis. 2020 Oct 21;7(12):ofaa509. doi: 10.1093/ofid/ofaa509. eCollection 2020 Dec.</mixed-citation><mixed-citation xml:lang="en">Amenta EM, Spallone A, Rodriguez-Barradas MC, et al. Post-acute COVID-19: An overview and approach to classification. Open Forum Infect Dis. 2020 Oct 21;7(12):ofaa509. doi: 10.1093/ofid/ofaa509. eCollection 2020 Dec.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Halpin SJ, McIvor C, Whyatt EG, et al. Post-discharge symptoms and rehabilitation needs in survivors of COVID-19 infection: A cross-sectional evaluation. J Med Virol. 2021;93:1013-22. doi: 10.1002/jmv.26368</mixed-citation><mixed-citation xml:lang="en">Halpin SJ, McIvor C, Whyatt EG, et al. Post-discharge symptoms and rehabilitation needs in survivors of COVID-19 infection: A cross-sectional evaluation. J Med Virol. 2021;93:1013-22. doi: 10.1002/jmv.26368</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Rhie SJ, Jung EY, Shim I. The role of neuroinflammation on pathogenesis of affective disorders. J Exerc Rehabil. 2020;16:2-9. doi: 10.12965/jer.2040016.008. eCollection 2020 Feb.</mixed-citation><mixed-citation xml:lang="en">Rhie SJ, Jung EY, Shim I. The role of neuroinflammation on pathogenesis of affective disorders. J Exerc Rehabil. 2020;16:2-9. doi: 10.12965/jer.2040016.008. eCollection 2020 Feb.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Ritchie K, Chan D, Watermeyer T. The cognitive consequences of the COVID-19 epidemic: collateral damage? Brain Commun. 2020 May 28;2(2):fcaa069. doi: 10.1093/brain-comms/fcaa069. eCollection 2020.</mixed-citation><mixed-citation xml:lang="en">Ritchie K, Chan D, Watermeyer T. The cognitive consequences of the COVID-19 epidemic: collateral damage? Brain Commun. 2020 May 28;2(2):fcaa069. doi: 10.1093/brain-comms/fcaa069. eCollection 2020.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
