ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2021.76.05ymj-589Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHВлияние гипотермии на реакции церебральных микрососудов крысы в условиях гемодинамической стабильности и при кровопотереEffect of hypothermia of the rat cerebral microvascular reactions under conditions of hemodynamic stability and blood losshttps://orcid.org/0000-0001-6412-529XМельниковаН. Н.MelnikovaN. N.

Мельникова Надежда Николаевна – к.б.н., с.н.с.

г. Санкт-Петербург

Melnikova Nadezhda Nikolaevna – Ph.D., Senior Researcher

Researcher-ID: J-8599-2018

St. Petersburg

MelnikovaNN@infran.ruФГБУН Институт физиологии им. И.П. Павлова РАНРоссияI.P.Pavlov Institute of Physiology RASRussian Federation202104052025042327Copyright © Мельникова Н.Н., 20252025Мельникова Н.Н.Melnikova N.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/589

Изучены реакции микрососудистого русла коры головного мозга крыс при гемодинамической стабильности и подвергшихся кровопотере при непрерывном понижении температуры тела вплоть до гипотермической остановки дыхания животного. Получены результаты, что в группе животных без кровопотери охлаждение приводило к первоначальной кратковременной вазодилатации и последующей вазоконстрикции на 10-20% от нормы. В группе животных с предварительно вызванной геморрагией сужение сосудов усилилось во время погружения животного в воду. Тем не менее, функциональное состояние животного при кровопотере и последующем охлаждении незначительно отличалось от нормоволемического состояния организма при гипотермическом воздействии.

This research studies the reaction of microcirculation of the cerebral cortex of rats with hemodynamic stability and the blood loss, with continuous exposure to decreasing body temperature till to the hypothermal arrest of the animal's breathing. The results were obtained that in the group of animals without hemorrhage, the cooling led to an initial short-term vasodilation and subsequent vasoconstriction up to 10-20% of the norm. In the group of animals with a pre-caused by hemorrhage, the narrowing of the vessels was 20% at the normothermia and intensified during the animal immersion in water on 35% of the initial state of the vessels. However, the functional state of the animal during blood loss and the subsequent cooling slightly differed from the normovolemic state of the body under hypothermic influence.

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The authors declare that there are no conflicts of interest present.