ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2021.76.03ymj-587Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHИсследование ассоциации полиморфных вариантов генов серотонинергической системы (5-HTT, HTR1B, HTR2A, HTR2C и TPH1) с болезнью Паркинсона и ее клиническими особенностями у татарAssociation analysis of serotonin system gene polymorphisms (5-HTT, HTR1B, HTR2A, HTR2C, and TPH1) with the risk of Parkinson's disease in Tatarshttps://orcid.org/0000-0001-5516-0587АхмадееваГ. Н.AkhmadeevaG. N.

Ахмадеева Гульнара Наилевна – к.м.н., невролог

г. Уфа

Akhmadeeva Gulnara Nailevna – MD, PhD, neurologist

nevrolog.ufa@gmail.comhttps://orcid.org/0000-0002-9600-5468ХидиятоваИ. М.KhidiyatovaI. M.

Хидиятова Ирина Михайловна – д.б.н., проф.

Khidiyatova Irina Mikhaylovna – Prof.

imkhid@mail.ruhttps://orcid.org/0000-0001-8823-8678НасибуллинТ. Р.NasibullinT. R.

Насибуллин Тимур Русланович – к.б.н.

Nasibullin Timur Ruslanovich – PhD

nasibullin-tr@yandex.ruhttps://orcid.org/0000-0001-9499-5632ГилязоваИ. Р.GilyazovaI. R.

Гилязова Ирина Ришатовна – к.б.н.

Gilyazova Irina Rishatovna – PhD

gilyasova_irina@mail.ruУмутбаевС. В.UmutbaevS. V.

Умутбаев Салават Вилсамович – невролог

г. Уфа

Umutbaev Salavat Vilsamovich – neurologist

umutbaevs@mail.ruТаюповаГ. Н.TayupovaG. N.

Таюпова Гульназ Наиловна – к.м.н., невролог

г. Уфа

Tayupova Gulnaz Nailovna – neurologist

nevrolog-rkb@gmail.comБайтимеровА. Р.BajtimerovA. R.

Байтимеров Азамат Рамзович – к.м.н., директор

г. Уфа

Baitimerov Azamat Ramzovich – MD, PhD, neurologist, director

Ramza30@bk.ruhttps://orcid.org/0000-0003-1246-4833МагжановР. В.MagzhanovR. V.

Магжанов Рим Валеевич – д.м.н., проф.

Magzhanov Rim Valeevich – Prof.

mc-janoff@yandex.ruhttps://orcid.org/0000-0003-2987-3334ХуснутдиноваЭ. К.KhusnutdinovaE. K.

Хуснутдинова Эльза Камилевна – д.б.н., проф., директор 

Khusnutdinova Elza Kamilevna – Prof, director

Международный медицинский центр им. В.С. Бузаева; Башкирский ГМУ; Институт биохимии и генетики Уфимского ФИЦ РАНРоссияV.S. Buzaev International Medical Center; Bashkir State Medical University, Ministry of Healthcare of the Russian Federation; Institute of Biochemistry and Genetics Ufa Science CentreRussian FederationИнститут биохимии и генетики Уфимского ФИЦ РАН; Башкирский ГУРоссияInstitute of Biochemistry and Genetics Ufa Science Centre; Bashkir State UniversityRussian FederationИнститут биохимии и генетики Уфимского ФИЦ РАНРоссияInstitute of Biochemistry and Genetics Ufa Science CentreRussian FederationГБУЗ Республиканская клиническая больница им. Г.Г. КуватоваРоссияState budgetary healthcare institution Kuvatov Republican clinical hospital; Bashkir State Medical University Ministry of Healthcare of the Russian FederationRussian FederationРКБ им. Г.Г. Куватова; Клинический институт неврологии и реабилитации «Медстандарт»РоссияState budgetary healthcare institution Kuvatov Republican clinical hospital; Clinical Institute of Neurology and Rehabilitation National medical holding Limited Liability Company «Medstandart»Russian FederationКлинический институт неврологии и реабилитации «Медстандарт»РоссияClinical Institute of Neurology and Rehabilitation National medical holding Limited Liability Company «Medstandart»Russian FederationБашкирский ГМУРоссияBashkir State Medical University Ministry of Healthcare of the Russian FederationRussian FederationИнститут биохимии и генетики Уфимского ФИЦ РАНРоссияInstitute of Biochemistry and Genetics Ufa Science Centre; Bashkir State UniversityRussian Federation202104052025041420Copyright © Ахмадеева Г.Н., Хидиятова И.М., Насибуллин Т.Р., Гилязова И.Р., Умутбаев С.В., Таюпова Г.Н., Байтимеров А.Р., Магжанов Р.В., Хуснутдинова Э.К., 20252025Ахмадеева Г.Н., Хидиятова И.М., Насибуллин Т.Р., Гилязова И.Р., Умутбаев С.В., Таюпова Г.Н., Байтимеров А.Р., Магжанов Р.В., Хуснутдинова Э.К.Akhmadeeva G.N., Khidiyatova I.M., Nasibullin T.R., Gilyazova I.R., Umutbaev S.V., Tayupova G.N., Bajtimerov A.R., Magzhanov R.V., Khusnutdinova E.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/587

Нарушение метаболизма серотонина может играть определенную роль в патогенезе развития болезни Паркинсона (БП). Проведен анализ ассоциации полиморфных вариантов генов серотонинергической системы: локусов Stin2 и 5-HTTLPR гена 5-HTT (транспортера серотонина), rs6296 гена HTR1B, rs6311 гена HTR2A, rs6318 гена HTR2C (рецепторов серотонина) и rs1800532 гена TPH1 (триптофангидроксилазы) с БП и ее клиническими формами у пациентов татарской этнической принадлежности, проживающих на территории Республики Башкортостан. В результате исследования с развитием БП в целом и с ее акинетико-ригидной формой установлены ассоциации аллеля rs1800532*G и генотипа rs1800532*G/G гена TPH1. С болезнью Паркинсона и с ее смешанной (акинетико-ригидно-дрожательной) формой обнаружена ассоциация аллеля STin2*12 гена 5-HTT. В результате анализа влияния исследуемых полиморфных вариантов генов на возраст манифестации БП обнаружены ассоциации аллеля STin2*12 гена 5-HTT с более поздним возрастом развития болезни (после 60 лет), аллеля rs1800532*G гена TPH1 и у мужчин - аллеля rs6318*C гена HTR2C - с дебютом заболевания от 45 до 60 лет.

Disruption of serotonin metabolism may play a role in the pathogenesis of Parkinson's disease (PD). An analysis of the association of polymorphic variants of the genes of the serotonergic system was carried out: Stin2 and 5-HTTLPR loci of the 5-HTT gene (serotonin transporter), rs6296 of the HTR1B gene, rs6311 of the HTR2A gene, rs6318 of the HTR2C gene (serotonin receptors) and rs1800532 TPH1 gene (tryptophan hydroxylase) with PD and its clinical forms in patients of Tatar ethnicity living in the Republic of Bashkortostan. The study included 257 patients with sporadic PD and 368 healthy individuals. As a result of the study with the development of PD in general and with its akinetic-rigid subtype, associations of the rs1800532*G allele and the rs1800532*G/G genotype of the TPH1 gene were established. Associations of the rs6296*G/C genotypes of the HTR1B gene and rs6318*C/C of the HTR2C gene were also revealed with the akinetic-rigid subtype of PD. The association of the STin2*12 allele of the 5-HTT gene was found with PD and the akinetic-rigid subtype with tremor (mixed subtype). An analysis of the influence of the studied polymorphic variants of genes on the age of PD manifestation revealed an association of the STin2*12 allele of the 5-HTT gene with a later age of disease development (after 60 years), and an association of the rs6318*C allele of the HTR2C gene (in men) and the rs1800532*G allele of the TPH1 gene with the onset of the disease from 45 to 60 years old.

болезнь Паркинсонасеротонинполиморфные варианты геновтриптофангидроксилазатранспортер серотонинарецепторы серотонинаParkinson's diseaseserotoninpolymorphic variants of the genetryptophanserotonin transporterserotonin receptorsИсследование поддержано грантом РФФИ р_а №19-015-00331; образцы ДНК для исследования взяты из «Коллекции биологических материалов человека» ИБГ УФИЦ РАН, поддержанной Программой биоресурсных коллекций ФАНО России (соглашение № 007-030164/2).The work was carried out on the equipment of the Center for Collective Use “Biomika” (Department of Biochemical Research Methods and Nanobiotechnology of the RCKP “Agidel”) and UNU “KODINK”. The study was supported by the RFBR grant r_a No. 19-015-00331; DNA samples for research were taken from the "Collection of Human Biological Materials" of the IBG UFIC RAS, supported by the Bioresource Collections Program of the Federal Agency for Scientific Organizations of Russia (agreement No. 007-030164 /2).ReferencesБагыева Г.Х. 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The authors declare that there are no conflicts of interest present.