ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2021.74.16ymj-579Research ArticleГИГИЕНА, САНИТАРИЯ, ЭПИДЕМИОЛОГИЯ И МЕДИЦИНСКАЯ ЭКОЛОГИЯHYGIENE, SANITATION, EPIDEMIOLOGY AND MEDICAL ECOLOGYРаспространенность восточноазиатских (East Asian cagA) и западных вариантов гена cagA (Western cagA) Helicobacter pylori в ЯкутииPrevalence of East Asian (East CagA) and Western variants of the cagA (Western cagA) gene of Helicobacter pylori in Yakutiahttps://orcid.org/0000-0002-4710-1592ГотовцевН. Н.GotovtsevN. N.

Готовцев Ньургун Наумович – н.с.

Gotovtsev Nyurgun Naumovich – Scientific researcher, laboratory of molecular genetics

677000, Sakha Republic, Yakutsk, Yaroslavsky st. 6/3. Phone: 89141062015

Donzcrew@mail.ruhttps://orcid.org/0000-0002-6984-7934БарашковН. А.BarashkovN. A.

Барашков Николай Алексеевич – к.б.н., в.н.с.-руковод. лаб.

Barashkov Nikolay Alekseevich – Candidate of biological sciences, Leading Researcher of laboratory of molecular genetics

677000, Sakha Republic, Yakutsk, Yaroslavsky st. 6/3. Phone: 8-(4112) 31-93-94

barashkov2004@mail.ruhttps://orcid.org/0000-0001-6866-9462ПшенниковаВ. Г.PshennikovaV. G.

Пшенникова Вера Геннадиевна – к.б.н., в.н.с.-руковод. лаб.

Pshennikova Vera Gennadievna – Candidate of Biological Sciences, Leading Researcher, Head of laboratory of Populational Genetics

677000, Sakha Republic, Yakutsk, Yaroslavsky st. 6/3. Phone: 8-(4112) 31-93- 94

pshennikovavera@mail.ruПакМ. В.PakM. V.

Пак Мария Владимировна – аспирант Медицинского института

г. Якутск

Pak Maria Vladimirovna – postgraduate student of the Medical institute

677013, Sakha Republic, Yakutsk, Oyunskogo st. 27

pakmv@mail.ruЛоскутоваК. С.LoskutovaK. S.

Лоскутова Кюнняй Саввична – к.м.н., доцент Медицинского института

г. Якутск

Loskutova Kiunnai Savvichna – Candidate of Medical Science, Associate Professor

677013, Sakha Republic, Yakutsk, Oyunskogo st. 27

loskutovaks@mail.ruhttps://orcid.org/0000-0002-6952-3868ФедороваС. А.FedorovaS. A.

Федорова Сардана Аркадьевна – д.б.н., зав. науч.-иссл. лаб. Института естественных наук

г. Якутск

Fedorova Sardana Arkadievna – Doctor of biological sciences, Head of the Research Laboratory of Molecular Biology Institute of Natural Sciences

677010, Sakha Republic, Yakutsk, Kulakovsky st. 46

sardaanafedorova@mail.ruФГБНУ «Якутский научный центр комплексных медицинских проблем»РоссияFederal State Budgetary Scientific Institution "Yakut Science Centre of complex medical problems"Russian FederationФГАОУ ВО «Северо-Восточный федеральный университет им. М.К. Аммосова»РоссияFederal State Autonomous Educational Institution of Higher Education "North-Eastern Federal University M.K. Ammosov"Russian FederationФГАОУ ВО «Северо-Восточный федеральный университет им. М.К. Аммосова»РоссияMedical institute, Federal State Autonomous Educational Institution of Higher Education "North-Eastern Federal University M.K. Ammosov"Russian Federation202110052025026367Copyright © Готовцев Н.Н., Барашков Н.А., Пшенникова В.Г., Пак М.В., Лоскутова К.С., Федорова С.А., 20252025Готовцев Н.Н., Барашков Н.А., Пшенникова В.Г., Пак М.В., Лоскутова К.С., Федорова С.А.Gotovtsev N.N., Barashkov N.A., Pshennikova V.G., Pak M.V., Loskutova K.S., Fedorova S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/579

Приведены результаты изучения распространенности восточноазиатских и западных вариантов гена cagA среди штаммов Helicobacter pylori в Якутии. В исследованной нами выборке образцов ДНК Helicobacter pylori (H. pylori), выделенных из биоптатов пациентов с гастродуоденальными заболеваниями, преобладают западные варианты гена cagA (Western cagA), в то время как восточноазиатские варианты гена cagA (East Asian cagA) не были обнаружены. Остальные образцы не относятся ни к западному (Western cagA), ни к восточноазиатскому (East Asian cagA) варианту гена cagA, что может указывать на наличие специфических локальных вариантов гена cagA среди штаммов Н. pylori, циркулирующих в Якутии.

The results of studying the prevalence of East Asian and Western variants of the cagA gene among Helicobacter pylori strains in Yakutia are presented. In the studied sample of Helicobacter pylori (H. pylori) DNA samples isolated from biopsies of patients with gastroduodenal diseases, western variants of the cagA gene (Western cagA) are prevailing, while East Asian variants of the cagA gene (East Asian cagA) were not found. The rest of the samples do not belong to either the Western (Western cagA) or the East Asian (East Asian cagA) variant of the cagA gene, which may indicate the presence of specific local variants of the cagA gene among H. pylori strains circulating in Yakutia.

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The authors declare that there are no conflicts of interest present.