ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2021.74.02ymj-565Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHУровень Д-димера как предиктор неблагоприятных исходов у больных ишемическим инсультомD-dimer level as a predictor of adverse outcomes in patients with ischemic strokeКоробейниковИ. В.KorobeinikovI. V.

Коробейников Иван Викторович – м.н.с.;

врач невролог, зам. главного врача-руковод. регионального сосудистого центра

Korobeinikov Ivan Viktorovich - Junior Researcher, Department of Biomedical Research and Technologies, neurologist, deputy chief physician, head of the regional vascular center

irk.ivan@gmail.comГороховаА. В.GorokhovaA. V.

Горохова Анна Владиславовна – врач эпидемиолог

Gorokhova Anna Vladislavovna - doctor and epidemiologist

av.vybivantseva@gmail.comАндрееваЕ. О.AndreevaE. O.

Андреева Елена Орестовна – к.м.н., врач

Andreeva Elena Orestovna - candidate of medical sciences, doctor of the clinical diagnostic laboratory

elcool26@mail.ruКоробейниковаЛ. В.KorobeinikovaL. V.

Коробейникова Лилия Викторовна – м.н.с.

Korobeinikova Liliya Viktorovna - Junior Researcher, Department of Biomedical Research and Technologies

klv11.07@mail.ruИноземцевП. О.InozemtsevP. O.

Иноземцев Павел Олегович – к.фарм.н., с.н.с.

Inozemtsev Pavel Olegovich - candidate of Pharmaceutical Sciences, Senior Researcher of the Department of Biomedical Research and Technologies

p.inozemcev@rambler.ruЛепеховаС. А.LepekhovaS. A.

Лепехова Светлана Александровна – д.б.н., зав. Отделом

Lepekhova Svetlana Aleksandrovna - Doctor of Biological Sciences, Head of the Department of Medical and Biological Research and Technologies

lepekhova_sa@mail.ruАпарцинК. А.ApartsinK. A.

Апарцин Константин Анатольевич – д.м.н., проф., директор

Apartsin Konstantin Anatolyevich - Doctor of Medical Sciences, Professor, Director

dr.apartsin@yahoo.comИркутский научный центр СО РАН; Иркутская областная клиническая больницаРоссияIrkutsk Regional Clinical HospitalRussian FederationИркутская областная клиническая больницаРоссияIrkutsk Regional Clinical HospitalRussian FederationИркутский научный центр СО РАНРоссияIrkutsk Scientific Center, Siberian Branch of the Russian Academy of SciencesRussian FederationИркутский научный центр СО РАНРоссияIrkutsk Scientific Center of the Siberian Branch of the Russian Academy of SciencesRussian Federation20211005202502913Copyright © Коробейников И.В., Горохова А.В., Андреева Е.О., Коробейникова Л.В., Иноземцев П.О., Лепехова С.А., Апарцин К.А., 20252025Коробейников И.В., Горохова А.В., Андреева Е.О., Коробейникова Л.В., Иноземцев П.О., Лепехова С.А., Апарцин К.А.Korobeinikov I.V., Gorokhova A.V., Andreeva E.O., Korobeinikova L.V., Inozemtsev P.O., Lepekhova S.A., Apartsin K.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/565

Проведена проверка гипотезы о том, что уровень D-димера, измеренный в первые 96 ч от начала госпитализации, имеет прогностическое значение в отношении летальности у пациентов с острым ишемическим инсультом в остром и раннем восстановительном периодах.Установлено, что уровень D-димера ≥ 5 ВГН является предиктором неблагоприятного исхода в обследованнной группе, что может потребовать изменения тактики применения антикоагулянтов, например, назначения лечебных доз антикоагулянтов, а не профилактических.

The hypothesis tested that the level of D-dimer, measured in the first 96 hours from the beginning of hospitalization, has a predictive value in relation to mortality in patients with acute ischemic stroke in the acute and early recovery periods.It was found that the level of D-dimer ≥ 5 VGN is a predictor of an unfavorable outcome in the examined group, which may require a change in the tactics of using anticoagulants, for example, therapeutic doses of anticoagulants, rather than prophylactic ones.

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The authors declare that there are no conflicts of interest present.