ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2021.74.01ymj-564Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHПолиморфный маркер RS 137100 гена LEPR и метаболические нарушения у коренного населения ЯкутииPolymorphic marker RS 137100 of the LEPR gene and metabolic disorders in the indigenous population of Yakutiahttps://orcid.org/0000-0002-7973-6103АммосоваЕ. П.AmmosovaE. P.

Аммосова Елена Петровна – к.м.н., в.н.с. Научно-исследовательский центр Медицинского института

Ammosova Elena Petrovna - Candidate of Medical Sciences, Leading Researcher, Research Center of the Medical Institute;

Associate Professor of the Department of Pharmacology and Pharmacy

tel.: +79644243908

ammosovael@mail.ruhttps://orcid.org/0000-0003-2746-0608КлимоваТ. М.KlimovaT. M.

Климова Татьяна Михайловна – к.м.н., доцент МИ;

с.н.с.

Klimova Tatiana Mikhailovna - Candidate of Medical Sciences, Associate Professor, Department of Pharmacology and Pharmacy, Medical Institute;

Senior Researcher, Department of Epidemiology of Chronic Noncommunicable Diseases

Yakutsk

tel.: +79142336724

biomedykt@mail.ruhttps://orcid.org/0000-0002-1395-8256ЗахароваР. Н.ZakharovaR. N.

Захарова Раиса Николаевна – к.м.н., в.н.с. НИЦ МИ

Zakharova Raisa Nikolaevna - Candidate of Medical Sciences, Leading Researcher, Research Center of the Medical Institute

677000, Yakutsk, 27 Ulitsa Oyunskogo, tel.: +79142223002

prn.inst@mail.ruhttps://orcid.org/0000-0002-7973-6103ФедоровА. И.FedorovA. I.

Федоров Афанасий Иванович – к.б.н., с.н.с. НИЛ молекулярной медицины и генетики человека МИ

Fedorov Afanasy Ivanovich - Candidate of Biological Sciences, Senior Scientist, Research Laboratory of Molecular Medicine and Human Genetics of the Medical Institute

677000, Yakutsk, 27 Ulitsa Oyunskogo, tel. +79142332966

fedorow@yandex.ruhttps://orcid.org/0000-0003-0986-7754БалтахиноваМ. Е.BaltakhinovaM. E.

Балтахинова Марина Егоровна – врач терапевт

Baltakhinova Marina Egorovna - General Practitioner

Yakutsk, 20/1 Ulitsa Poyarkova 20/1, tel.: +79142710634

bmeg@rambler.ruСВФУ им. М.К. АммосоваРоссияNEFU; M.K. Ammosov North-Eastern Federal UniversityRussian FederationСВФУ; ЯНЦ комплексных медицинских проблемРоссияM.K. Ammosov North-Eastern Federal University; Yakutsk Scientific Center for Complex Medical ProblemsRussian FederationСВФУРоссияM.K. Ammosov North-Eastern Federal UniversityRussian Federationмедицинская клиника “Аврора”РоссияAurora Medical ClinicRussian Federation2021100520250259Copyright © Аммосова Е.П., Климова Т.М., Захарова Р.Н., Федоров А.И., Балтахинова М.Е., 20252025Аммосова Е.П., Климова Т.М., Захарова Р.Н., Федоров А.И., Балтахинова М.Е.Ammosova E.P., Klimova T.M., Zakharova R.N., Fedorov A.I., Baltakhinova M.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/564

Целью исследования был поиск ассоциативных связей полиморфного маркера rs 1137100 гена LEPR с липидным спектром, метаболическим синдромом и его компонентами у коренного населения Якутии. Обследованы 227 представителей якутской национальности, постоянно проживающих в селе Бердигестях Горного района Якутии. Установлена статистически значимая связь между аллельным вариантом A, генотипами АА/AG гена LEPR с гипоальфахолестеринемией. Ассоциации с метаболическим синдромом и его компонентами не выявлено.

The aim of the study was to search for associations of the rs 1137100 polymorphic marker of the LEPR gene with the lipid spectrum, metabolic syndrome and its components in the indigenous inhabitants of Yakutia. The study involved 227 representatives of the Yakut nationality, permanently residing in the village of Berdigestyah, Gorny region of Yakutia. A statistically significant relationship was established between allelic variant A, AA / AG genotypes of the LEPR gene with hypoalphacholesterolemia. No association with metabolic syndrome or its components was found.

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The authors declare that there are no conflicts of interest present.