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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25789/YMJ.2021.75.24</article-id><article-id custom-type="elpub" pub-id-type="custom">ymj-551</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАУЧНЫЕ ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SCIENTIFIC REVIEWS AND LECTURES</subject></subj-group></article-categories><title-group><article-title>Функциональная роль рецептора трансферрина – TfR1</article-title><trans-title-group xml:lang="en"><trans-title>The functional role of the transferrin receptor - TfR1</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Патракеева</surname><given-names>В. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Patrakeeva</surname><given-names>V. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Патракеева Вероника Павловна – к.б.н., в.н.с., зав. лаб.</p></bio><bio xml:lang="en"><p>Patrakeeva Veronika Pavlovna - PhD (Biol.), Head of the Department of Environmental Immunology</p></bio><email xlink:type="simple">patrakeewa.veronika@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Контиевская</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kontievskaya</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Контиевская Елена Владимировна – м.н.с</p></bio><bio xml:lang="en"><p>Kontievskaya Elena Vladimirovna - junior researcher of the Department of Environmental Immunology</p><p>Arkhangelsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт физиологии природных адаптаций ФГБУН ФИЦКИА УрО РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Environmental Physiology, N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch RAS</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>27</day><month>04</month><year>2025</year></pub-date><volume>0</volume><issue>3</issue><fpage>94</fpage><lpage>97</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Патракеева В.П., Контиевская Е.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Патракеева В.П., Контиевская Е.В.</copyright-holder><copyright-holder xml:lang="en">Patrakeeva V.P., Kontievskaya E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/551">https://ymj.elpub.ru/jour/article/view/551</self-uri><abstract><p>В обзоре литературы представлены современные данные о функциональной роли рецептора трансферрина TfR1. Обобщены сведения о значимости данного рецептора в функционировании различных клеток организма, показана разнообразная роль данного рецептора в зависимости от типа клеток и стадии их активации.</p></abstract><trans-abstract xml:lang="en"><p>The article presents modern data on the functional role of the transferrin receptor - TfR1. The information on the significance of this receptor in the functioning of various cells of the body is generalized, and the diverse role of this receptor depending on the type of cells and the stage of their activation is shown.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рецептор</kwd><kwd>трансферрин</kwd><kwd>TfR1</kwd><kwd>CD71</kwd><kwd>железо</kwd><kwd>эритроциты</kwd><kwd>лимфоциты</kwd><kwd>ферроптоз</kwd><kwd>онкология</kwd></kwd-group><kwd-group xml:lang="en"><kwd>receptor</kwd><kwd>transferrin</kwd><kwd>TfR1</kwd><kwd>CD71</kwd><kwd>iron</kwd><kwd>erythrocytes</kwd><kwd>lymphocytes</kwd><kwd>ferroptosis</kwd><kwd>oncology</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена в рамках программы фундаментальных научных исследований по теме лаборатории экологической иммунологии Института физиологии природных адаптаций ФГБУН ФИЦКИА УрО РАН № гос. регистрации АААА-А17-117033010124-7.</funding-statement><funding-statement xml:lang="en">This work was carried out as part of a fundamental research program on the topic of the laboratory of environmental immunology by the FCIARctic project № АААА-А17-117033010124-7.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">A comparison of transferrin-receptor and epithelial cellular adhesion molecule targeting for microfluidic separation of cancer cells / Li X., Zhou Y., Wickramaratne B., et al // Biomedical microdevices. 2021. 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