ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2021.75.23ymj-550Research ArticleНАУЧНЫЕ ОБЗОРЫ И ЛЕКЦИИSCIENTIFIC REVIEWS AND LECTURESАктивность 5-нуклеотидазы в плаценте при цитомегаловирусной инфекции как маркер развития преэкламп5-nucleotidase activity in the placenta in cytomegalovirus infection as a marker of the development of preeclampsiahttps://orcid.org/0000-0001-8938-3594ДовжиковаИ. В.DovzhikovaI. V.

Довжикова Инна Викторовна – д.б.н., в.н.с.

Dovzhikova Inna Viktorovna - PhD, D.Sc. (Biol.), Leading Staff Scientist of Laboratory of Mechanisms of Etiopathogenesis and Recovery Processes of the Respiratory System at Non-Specific Lung Diseases

dov_kova100@rambler.ruhttps://orcid.org/0000-0003-0212-0201АндриевскаяИ. А.AndrievskayaI. A.

Андриевская Ирина Анатольевна – д.б.н., проф. РАН, зав. лаб.

Andrievskaya Irina A. - PhD, D.Sc. (Biol.), Professor RAS, Head of Laboratory of Mechanisms of Etiopathogenesis and Recovery Processes of the Respiratory System at Non-Specific Lung Diseases

https://orcid.org/0000-0002-6763-9744ПетроваК. К.PetrovaK. K.

Петрова Ксения Константиновна – врач акушер-гинеколог

Petrova Ksenia Konstantinovna - MD, obstetrician-gynecologist

irina-andrievskaja@rambler.ruФГБНУ «Дальневосточ. науч. центр физиологии и патологии дыхания»РоссияFar Eastern Scientific Center of Physiology and Pathology of RespirationRussian Federation202127042025039194Copyright © Довжикова И.В., Андриевская И.А., Петрова К.К., 20252025Довжикова И.В., Андриевская И.А., Петрова К.К.Dovzhikova I.V., Andrievskaya I.A., Petrova K.K.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/550

Изучалась активность 5'-нуклеотидазы в плаценте от женщин с реактивацией цитомегаловирусной (ЦМВ) инфекции в третьем триместре беременности и преэклампсией. Выявлено повышение интенсивности гистохимической реакции на 5'-нуклеотидазу в синцитиотрофобласте ворсин по сравнению с контрольной группой (без реактивации), свидетельствующее об увеличении активности фермента. Предполагается, что развитию характерных признаков преэклампсии при ЦМВ инфекции во время беременности могло способствовать увеличение активности 5'-нуклеотидазы, которое создавало высокий уровень аденозина.

We studied the activity of 5'-nucleotidase in the placenta from women with reactivation of cytomegalovirus (CMV) infection in the third trimester of pregnancy and preeclampsia. An increase in the intensity of the histochemical reaction for 5'-nucleotidase in the villi syncytiotrophoblast was revealed in comparison with the control group (without reactivation), indicating an increase in the enzyme activity. In our opinion, the development of characteristic symptoms of preeclampsia in CMV infection during pregnancy could be facilitated by an increase in 5'-nucleotidase activity, which created a high level of adenosine.

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The authors declare that there are no conflicts of interest present.